What is the role of inflammation in the immune system?
the immune system's response to harmful stimuli, such as pathogens, damaged cells, toxic compounds, or irradiation. Recruits WBCs to infection.
what is TLR4 in immunology?
intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system.
TLR4 recognizes bacterial LPS with these two proteins?
MD2 and CD14
TLR4 mediated signaling step 1: LPS and LBP
Lipopolysaccharide (LPS)-binding protein (LBP) binds LPS to cell surface receptors (TLR4), thereby initiating an innate host response.
TLR4 mediated signaling step 2: myD88
provides instructions for making a protein involved in signaling within immune cells.
TLR4 mediated signaling step 3: IKK
IKK triggers IKB
TLR4 mediated signaling step 4: IκB kinase
The IkBs bind to NF-kB IκBα is an unstable protein whose rapid degradation is slowed upon binding to NF-κB.
TLR4 mediated signaling step 5: in the nucleus
NfkB goes through transcription and inflammatory cytokine produced
TLR4 mediated signaling step 6: cytokines
- leave the cytoplasm
- recruit WBC's
- site of infection traced by PMN
- leads to bacteria. phagocytize.
what is NfkB's role in the in innate immune response?
NF-κB plays a critical role in regulating the survival, activation and differentiation of innate immune cells and inflammatory T cells