NAVBO's Vascular Biology Publication Alert
October 2014 Issue (papers published in September 2014)
NAVBO Members are highlighted in dark red
The American Journal of Pathology
Aaron M. Nadon, Mario J. Perez, Daniel Hernandez-Saavedra, Lynelle P. Smith, Yimu Yang, Linda A. Sanders,
Aneta Gandjeva, Jacob Chabon, Daniel E. Koyanagi, Brian B. Graham, Rubin M. Tuder, Eric P. Schmidt. Rtp801
Suppression of Epithelial mTORC1 Augments Endotoxin-Induced Lung Inflammation. Am J Pathol.,
184(9):2382 – 2389
Aicha Saadane, Natalia Mast, Casey D. Charvet, Saida Omarova, Wenchao Zheng, Suber S. Huang, Timothy S.
Kern, Neal S. Peachey, Irina A. Pikuleva. Retinal and Nonocular Abnormalities in Cyp27a1−/−Cyp46a1−/− Mice
with Dysfunctional Metabolism of Cholesterol. Am J Pathol., 184(9):2403 – 2419
Laurent Mesnard, Dominique Cathelin, Sophie Vandermeersch, Cédric Rafat, Yosu Luque, Julie Sohier, Dominique
Nochy, Loïc Garcon, Patrice Callard, Chantal Jouanneau, Marie-Christine Verpont, Pierre-Louis Tharaux, Alexandre
Hertig, Eric Rondeau. Genetic Background–Dependent Thrombotic Microangiopathy Is Related to Vascular
Endothelial Growth Factor Receptor 2 Signaling during Anti-Glomerular Basement Membrane
Glomerulonephritis in Mice. Am J Pathol., 184(9):2438 – 2449
Tanja Schönberger, Tobias Jürgens, Julia Müller, Nicole Armbruster, Christina Niermann, Simone Gorressen, Jan
Sommer, Huasong Tian, Gilbert di Paolo, Jürgen Scheller, Jens W. Fischer, Meinrad Gawaz, Margitta Elvers. Pivotal
Role of Phospholipase D1 in Tumor Necrosis Factor-α–Mediated Inflammation and Scar Formation after
Myocardial Ischemia and Reperfusion in Mice. Am J Pathol., 184(9):2450 – 2464
Ahmet Arac, Michele A. Grimbaldeston, Andrew R.B. Nepomuceno, Oluwatobi Olayiwola, Marta P. Pereira, Yasuhiro
Nishiyama, Anna Tsykin, Gregory J. Goodall, Ulrich Schlecht, Hannes Vogel, Mindy Tsai, Stephen J. Galli, Tonya M.
Bliss, Gary K. Steinberg. Evidence that Meningeal Mast Cells Can Worsen Stroke Pathology in Mice. Am J
Pathol., 184(9):2493 – 2504
Valeriy Lyzogubov, Xiaobo Wu, Purushottam Jha, Ruslana Tytarenko, Michael Triebwasser, Grant Kolar, Paula
Bertram, Puran S. Bora, John P. Atkinson, Nalini S. Bora. Complement Regulatory Protein CD46 Protects against
Choroidal Neovascularization in Mice. Am J Pathol., 184(9):2537 – 2548
Charles J. Lockwood, Murat Basar, Umit A. Kayisli, Ozlem Guzeloglu-Kayisli, William Murk, Jenny Wang, Nicole De
Paz, John P. Shapiro, Rachel J. Masch, Nihan Semerci, S. Joseph Huang, Frederick Schatz. Interferon-γ Protects
First-Trimester Decidual Cells against Aberrant Matrix Metalloproteinases 1, 3, and 9 Expression in
Preeclampsia. Am J Pathol., 184(9):2549 – 2559
Amany Tawfik, Shanu Markand, Mohamed Al-Shabrawey, Jamie N. Mayo, Jason Reynolds, Shawn E. Bearden,
Vadivel Ganapathy, Sylvia B. Smith. Alterations of Retinal Vasculature in Cystathionine–β-Synthase
Heterozygous Mice. Am J Pathol., 184(9):2573 – 2585
Debra L. Rateri, Frank M. Davis, Anju Balakrishnan, Deborah A. Howatt, Jessica J. Moorleghen, William N.
O’Connor, Richard Charnigo, Lisa A. Cassis, Alan Daugherty. Angiotensin II Induces Region-Specific Medial
Disruption during Evolution of Ascending Aortic Aneurysms. Am J Pathol., 184(9):2586 – 2595
Biochemical Journal
No vascular biology related publications this month
Blood
Mohan Rao LV, Esmon CT and Pendurthi UR. Endothelial cell protein C receptor: a multiliganded and
multifunctional receptor. Blood, 124:1553-62
Claes J, Vanassche T, Peetermans M, Liesenborghs L, Vandenbriele C, Vanhoorelbeke K, Missiakas D, Schneewind
O, Hoylaerts MF, Heying R and Verhamme P. Adhesion of Staphylococcus aureus to the vessel wall under flow
is mediated by von Willebrand factor–binding protein. Blood, 124:1669-76
Haddad G, Zhabyeyev P, Farhan M, Zhu LF, Kassiri Z, Rayner DC, Vanhaesebroeck B, Oudit GY and Murray AG.
Phosphoinositide 3-kinase β mediates microvascular endothelial repair of thrombotic microangiopathy.
Blood, 124: 2142-49
Lie-A-Ling M, Marinopoulou E, Li Y, Patel R, Stefanska M, Bonifer C, Miller C, Kouskoff V and Lacaud G. RUNX1
positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood
emergence. Blood, 124:e11-e20
Cancer Cell
No vascular biology related publications this month
Cancer Research
Wong AD and Searson PC. Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel
Platform. Cancer Research, 74:4937-4945
Cell
No vascular biology related publications this month
Clinical Science
Mariela M. Gironacci, Flavia M. Cerniello, Nadia A. Longo Carbajosa, Jorge Goldstein and Bruno D. Cerrato.
Protective axis of the renin–angiotensin system in the brain. Clin Sci., 127(5):295‑306
Leila Kheirandish‑Gozal, Yang Wang, Ryan C. Duggan, Sindhuja Harshan Vardhan, Hui‑Leng Tan, Helena Molero
Ramirez, Abdelnaby Khalyfa, Rakesh Bhattacharjee, Hari P.R. Bandla and David Gozal. Nitric oxide production by
monocytes in children with OSA and endothelial dysfunction. Clin Sci., 127(5):323‑330
Nirmal Parajuli, Vaibhav B. Patel, Wang Wang, Ratnadeep Basu and Gavin Y. Oudit. Loss of NOX2 (gp91phox)
prevents oxidative stress and progression to advanced heart failure. Clin Sci., 127(5):331‑340
Rick F. J. Kwekkeboom, Zhiyong Lei, Pieter A. Doevendans, René J. P. Musters and Joost P. G. Sluijter. Targeted
delivery of miRNA therapeutics for cardiovascular diseases: opportunities and challenges. Clin Sci.,
127(6):351‑365
Development
Nielsen, C.M., Cuervo, H., Ding, V.W., Kong, Y., Huang, E.J. and Wang, R.A. Deletion of Rbpj from postnatal
endothelium leads to abnormal arteriovenous shunting in mice. Development, 141(19):3782-3792
Developmental Biology
Fukuhara S, Zhang J, Yuge S, Ando K, Wakayama Y, Sakaue-Sawano A, Miyawaki A and Mochizuki N. Visualizing
the cell-cycle progression of endothelial cells in zebrafish. Developmental Biology, 393:10-23
Hua LL, Vedantham V, Barnes RM, Hu J, Robinson AS, Bressan M, Srivastava D and Black BL. Specification of
the mouse cardiac conduction system in the absence of Endothelin signaling. Developmental Biology,
393:245-254
Schupp M-O, Waas M, Chun C-Z and Ramchandran R. Transcriptional inhibition of etv2 expression is essential
for embryonic cardiac development. Developmental Biology, 393:71-83
Spracklen AJ, Fagan TN, Lovander KE and Tootle TL. The pros and cons of common actin labeling tools for
visualizing actin dynamics during Drosophila oogenesis. Developmental Biology, 393:209-226
Developmental Cell
Hudson N, Powner Michael B, Sarker Mosharraf H, Burgoyne T, Campbell M, Ockrim Zoe K, Martinelli R, Futter
Clare E, Grant Maria B, Fraser Paul A, Shima David T, Greenwood J and Turowski P. Differential Apicobasal
VEGF Signaling at Vascular Blood-Neural Barriers. Developmental Cell, 30:541-552
Klein, Klara R, Karpinich, Natalie O, Espenschied, Scott T, Willcockson, Helen H, Dunworth, William P, Hoopes,
Samantha L, Kushner, Erich J, Bautch, Victoria L and Caron, Kathleen M. Decoy Receptor CXCR7 Modulates
Adrenomedullin-Mediated Cardiac and Lymphatic Vascular Development. Developmental Cell, 30:528-540
Developmental Dynamics
Ito K, Morioka M, Kimura S, Tasaki M, Inohaya K and Kudo A. Differential reparative phenotypes between
zebrafish and medaka after cardiac injury. Developmental Dynamics, 243:1106-1115
EMBO
No vascular biology related publications this month
EMBO Reports
K. R. Katsumura, C. Yang, M. E. Boyer, L. Li and E. H. Bresnick. Molecular Basis of Crosstalk between
Oncogenic Ras and the Master Regulator of Hematopoiesis Gata-2. EMBO Rep, 15: 938-947
FASEB Journal
Seunghyung Lee and and Lawrence E. Goldfinger. Rlip76 Regulates Hif-1 Activity, Vegf Expression and
Secretion in Tumor Cells, and Secretome Transactivation of Endothelial Cells. The FASEB Journal, 28: 41584168
Dawei Sun, Shintaro Nakao, Fang Xie, Souska Zandi, Abouzar Bagheri, Mozhgan Rezaei Kanavi, Shahram Samiei,
Zahra-Soheila Soheili, Sonja Frimmel, Zhongyu Zhang et al. Molecular Imaging Reveals Elevated Vegfr-2
Expression in Retinal Capillaries in Diabetes: A Novel Biomarker for Early Diagnosis. The FASEB Journal, 28:
3942-3951
Katherine T. Bliss, Takehiro Tsukada, Stefanie Mares Novak, Maxim V. Dorovkov, Samar P. Shah, Chinedu Nworu,
Alla S. Kostyukova and and Carol C. Gregorio. Phosphorylation of Tropomodulin1 Contributes to the Regulation
of Actin Filament Architecture in Cardiac Muscle. The FASEB Journal, 28: 3987-3995
Rebecca Hutcheson, Jennifer Chaplin, Brenda Hutcheson, Faye Borthwick, Spencer Proctor, Sarah Gebb, Rashmi
Jadhav, Erika Smith, James C. Russell and and Petra Rocic. Mir-21 Normalizes Vascular Smooth Muscle
Proliferation and Improves Coronary Collateral Growth in Metabolic Syndrome. The FASEB Journal, 28: 40884099
Yukako Tani, Yosuke Isobe, Yuki Imoto, Eri Segi-Nishida, Yukihiko Sugimoto, Hiroyuki Arai, and Makoto Arita and
Eosinophils Control the Resolution of Inflammation and Draining Lymph Node Hypertrophy through the
Proresolving Mediators and Cxcl13 Pathway in Mice. The FASEB Journal, 28: 4036-4043
Genes & Development
No vascular biology related publications this month
Journal of Biological Chemistry
L. Li, Y. Zhang, J. Qiao, J. J. Yang and Z. R. Liu. Pyruvate Kinase M2 in Blood Circulation Facilitates Tumor
Growth by Promoting Angiogenesis. J Biol Chem, 289: 25812-25821
C. C. Pan, S. Kumar, N. Shah, D. G. Hoyt, L. J. Hawinkels, K. Mythreye and N. Y. Lee. Src-Mediated PostTranslational Regulation of Endoglin Stability and Function Is Critical for Angiogenesis. J Biol Chem, 289:
25486-25496
B. L. Parker, N. E. Shepherd, S. Trefely, N. J. Hoffman, M. Y. White, K. Engholm-Keller, B. D. Hambly, M. R. Larsen,
D. E. James and S. J. Cordwell. Structural Basis for Phosphorylation and Lysine Acetylation Cross-Talk in a
Kinase Motif Associated with Myocardial Ischemia and Cardioprotection. J Biol Chem, 289: 25890-25906
A. V. Samarelli, E. Riccitelli, L. Bizzozero, T. N. Silveira, G. Seano, M. Pergolizzi, G. Vitagliano, I. Cascone, G.
Carpentier, A. Bottos et al. Neuroligin 1 Induces Blood Vessel Maturation by Cooperating with the Alpha6
Integrin. J Biol Chem, 289: 25475
M. Philipp, I. M. Berger, S. Just and M. G. Caron. Overlapping and Opposing Functions of G Protein-Coupled
Receptor Kinase 2 (Grk2) and Grk5 During Heart Development. J Biol Chem, 289: 26119-26130
T. Yoshida, M. Yamashita, C. Horimai and M. Hayashi. Kruppel-Like Factor 4 Protein Regulates IsoproterenolInduced Cardiac Hypertrophy by Modulating Myocardin Expression and Activity. J Biol Chem, 289: 2610726118
Journal of Cell Biology
Zhu YT, Li F, Han B, Tighe S, Zhang S, Chen SY, Liu X, Tseng SC. Activation of RhoA-ROCK-BMP signaling
reprograms adult human corneal endothelial cells. J Cell Biol., 206(6):799-811
Journal of Cell Science
Ambesi A, McKeown-Longo PJ. Conformational remodeling of the fibronectin matrix selectively regulates
VEGF signaling. J Cell Sci., 127(Pt 17):3805-16
Journal of Clinical Investigation
Zhou Y, Wang Y, Tischfield M, Williams J, Smallwood PM, Rattner A, Taketo MM, Nathans J. Canonical WNT
signaling components in vascular development and barrier formation. J Clin Invest., 124(9):3825-46
D'Alessio S, Correale C, Tacconi C, Gandelli A, Pietrogrande G, Vetrano S, Genua M, Arena V, Spinelli A, PeyrinBiroulet L, Fiocchi C, Danese S. VEGF-C-dependent stimulation of lymphatic function ameliorates experimental
inflammatory bowel disease. J Clin Invest., 124(9):3863-78
Lyons TR, Borges VF, Betts CB, Guo Q, Kapoor P, Martinson HA, Jindal S, Schedin P. Cyclooxygenase-2dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer. J Clin Invest.,
124(9):3901-12
Park DY, Lee J, Park I, Choi D, Lee S, Song S, Hwang Y, Hong KY, Nakaoka Y, Makinen T, Kim P, Alitalo K, Hong
YK, Koh GY. Lymphatic regulator PROX1 determines Schlemm's canal integrity and identity. J Clin Invest.,
124(9):3960-74
Aspelund A, Tammela T, Antila S, Nurmi H, Leppänen VM, Zarkada G, Stanczuk L, Francois M, Mäkinen T,
Saharinen P, Immonen I, Alitalo K. The Schlemm's canal is a VEGF-C/VEGFR-3-responsive lymphatic-like
vessel. J Clin. Invest, 124(9):3975-86
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ, Rebstock AS, Worthington
RJ, Simone MI, Mota F, Rivilla F, Vallejo S, Peiró C, Sánchez Ferrer CF, Djordjevic S, Caulfield MJ, MacAllister RJ,
Selwood DL, Ahluwalia A, Hobbs AJ. Endothelial C-type natriuretic peptide maintains vascular homeostasis. J
Clin Invest.,124(9):4039-51
Gaetano Santulli, Anetta Wronska, Kunihiro Uryu, Thomas G. Diacovo, Melanie Gao, Steven O. Marx, Jan
Kitajewski, Jamie M. Chilton, Kemal Marc Akat, Thomas Tuschl, Andrew R. Marks and Hana Totary-Jain. A
selective microRNA-based strategy inhibits restenosis while preserving endothelial function. J Clin Invest.,
124(9):4102-14
Journal of Experimental Medicine
No vascular biology related publications this month
Journal of Lipid Research
No vascular biology related publications this month
Molecular and Cellular Biology
Lee JG, Heur M. Interleukin-1β-induced Wnt5a enhances human corneal endothelial cell migration through
regulation of Cdc42 and RhoA. Mol Cell Biol., 34(18):3535-45
Tian Y, Tian X, Gawlak G, O'Donnell JJ 3rd, Sacks DB, Birukova AA. IQGAP1 regulates endothelial barrier
function via EB1-cortactin cross talk. Mol Cell Biol., 34(18):3546-58
Molecular Biology of the Cell
No vascular biology related publications this month
Nature
Oscar R. Colegio, Ngoc-Quynh Chu, Alison L. Szabo, Thach Chu, Anne Marie Rhebergen, Vikram Jairam, Nika
Cyrus, Carolyn E. Brokowski, Stephanie C. Eisenbarth, Gillian M. Phillips, Gary W. Cline, Andrew J. Phillips & Ruslan
Medzhitov. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature,
513(7519):559–563
Nature Cell Biology
Fabienne Lescroart, Samira Chabab, Xionghui Lin, Steffen Rulands, Catherine Paulissen, Annie Rodolosse,
Herbert Auer, Younes Achouri, Christine Dubois, Antoine Bondue, Benjamin D. Simons & Cédric Blanpain. Early
lineage restriction in temporally distinct populations of Mesp1 progenitors during mammalian heart
development. Nature Cell Biology, 16(9):829-840.
Matthew L. Kutys & Kenneth M. Yamada. An extracellular-matrix-specific GEF–GAP interaction regulates Rho
GTPase crosstalk for 3D collagen migration. Nature Cell Biology, 16(9):909-917
Nature Genetics
Felipe R Lorenzo, Chad Huff, Mikko Myllymäki, Benjamin Olenchock, Sabina Swierczek, Tsewang Tashi, Victor
Gordeuk, Tana Wuren, Ge Ri-Li, Donald A McClain, Tahsin M Khan, Parvaiz A Koul, Prasenjit Guchhait, Mohamed E
Salama, Jinchuan Xing, Gregg L Semenza, Ella Liberzon, Andrew Wilson, Tatum S Simonson, Lynn B Jorde, William
G Kaelin Jr, Peppi Koivunen & Josef T Prchal. A genetic mechanism for Tibetan high-altitude adaptation. Nature
Genetics, 46(9):951-956
Nature Medicine
Min Xu,Jason S Nagati, Jian Xie, Jiwen Li, Holly Walters, Young-Ah Moon, Robert D Gerard, Chou-Long Huang,
Sarah A Comerford, Robert E Hammer, Jay D Horton, Rui Chen & Joseph A Garcia. An acetate switch regulates
stress erythropoiesis. Nature Medicine, 20(9):1018–1026
Phil Oh, Jacqueline E Testa, Per Borgstrom, Halina Witkiewicz, Yan Li & Jan E Schnitzer. In vivo proteomic
imaging analysis of caveolae reveals pumping system to penetrate solid tumors. Nature Medicine, 20(9):1062–
1068
PNAS
Lee MY, Luciano AK, Ackah E, Rodriguez-Vita J, Bancroft TA, Eichmann A, Simons M, Kyriakides TR, MoralesRuiz M, Sessa WC. Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic
substrates. Proc Natl Acad Sci U S A, 111(35):12865-70
Oladipupo SS, Smith C, Santeford A, Park C, Sene A, Wiley LA, Osei-Owusu P, Hsu J, Zapata N, Liu F, Nakamura
R, Lavine KJ, Blumer KJ, Choi K, Apte RS, Ornitz DM. Endothelial cell FGF signaling is required for injury
response but not for vascular homeostasis. Proc Natl Acad Sci U S A., 111(37):13379-84
Ulrich V, Konaniah ES, Herz J, Gerard RD, Jung E, Yuhanna IS, Ahmed M, Hui DY, Mineo C, Shaul PW. Genetic
variants of ApoE and ApoER2 differentially modulate endothelial function. Proc Natl Acad Sci U S A,
111(37):13493-8
Overby DR, Zhou EH, Vargas-Pinto R, Pedrigi RM, Fuchshofer R, Braakman ST, Gupta R, Perkumas KM, Sherwood
JM, Vahabikashi A, Dang Q, Kim JH, Ethier CR, Stamer WD, Fredberg JJ, Johnson M. Altered mechanobiology of
Schlemm's canal endothelial cells in glaucoma. Proc Natl Acad Sci U S A, 111(38):13876-81
Science
Douglas R. Green, Lorenzo Galluzzi, Guido Kroemer. Metabolic control of cell death. Science,
345(6203):1250256-1 - 1250256-11
Iman Fares, Jalila Chagraoui, Yves Gareau, Stéphane Gingras, Réjean Ruel, Nadine Mayotte, Elizabeth Csaszar,
David J. H. F. Knapp, Paul Miller, Mor Ngom, Suzan Imren, Denis-Claude Roy, Kori L. Watts, Hans-Peter Kiem,
Robert Herrington, Norman N. Iscove, R. Keith Humphries, Connie J. Eaves, Sandra Cohen, Anne Marinier, Peter W.
Zandstra, and Guy Sauvageau. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell selfrenewal. Science, 345(6203):1509-1512
Member Submissions
Hariharan S, Kelm RJ Jr, Strauch AR. The Purα / Purβ Single-Strand DNA-Binding Proteins Attenate SmoothMuscle Actin Gene Transactivation in Myofibroblasts. J Cell Physiol., 229(9):1256-7
Dabagh M, Jalali P, Butler PJ, Tarbell JM. Shear-induced force transmission in a multicomponent, multicell
model of the endothelium. J R Soc Interface, 11(98):20140431
Rogers NM, Sharifi-Sanjani M, Csányi G, Pagano PJ, Isenberg JS. Thrombospondin-1 and CD47 regulation of
cardiac, pulmonary and vascular responses in health and disease. Matrix Biol. 37C:92-101
Han H, Rosenhouse-Dantsker A, Gnanasambandam R, Epshtein Y, Chen Z, Sachs F, Minshall RD, Levitan I.
Silencing of Kir2 channels by caveolin-1: cross-talk with cholesterol. J Physiol., 592(Pt 18):4025-38
Boonen HC, Moesgaard SG, Birck MM, Christoffersen BO, Cirera S, Heegaard PM, Højbøge TR, Jensen LJ,
Mortensen A, Olsen LH, Sheykhzade M, Tang J, Lykkesfeldt J. Functional network analysis of obese and lean
Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs. Pflugers Arch.,
Lawendy AR, Bihari A, Sanders DW, Potter RF, Cepinskas G. The Severity of Microvascular Dysfunction Due to
Compartment Syndrome Is Diminished by the Systemic Application of CO-Releasing Molecule (CORM-3). J
Orthop Trauma,
Lacko, L.A., Massimiani, M., Sones, J.L., Hurtado, R., Salvi, S., Ferrazzani, S., Davisson, R.L., Campagnolo, L., and
Stuhlmann, H. Novel expression of EGFL7 in placental trophoblasts and endothelial cells and its implication
in preeclampsia. Mech Dev, 133:163-176
Qiwei Wang, Jun Ren, Stephanie Morgan, Zhenjie Liu, Changlin Dou, Bo Liu. Monocyte chemoattractant
protein-1 (MCP-1) regulates macrophage cytotoxicity in abdominal aortic aneurysm. PLoS One. 9(3):e92053