Supplemental Material: supporting references Supporting references for immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures in ASD Immune dysregulation and inflammation A total of 437 publications investigated a relationship between immune dysregulation and/or inflammation and ASD, with 416 implicating a relationship between immune dysregulation and/or inflammation and ASD. Twenty-one publications (all clinical studies) 1-21 failed to find an association between immune dysregulation or inflammation and ASD. Publications implicating a relationship between immune dysregulation and/or inflammation and ASD either reported about generalized immune dysregulation/inflammation, or reported these in a specific organ system (e.g., brain or gastrointestinal tract). An association between ASD and generalized immune dysregulation and/or inflammation was implicated in 320 publications, including 155 clinical studies 22-176, 91 review articles or hypothesis-generating papers 177-267, 34 studies using animal models 268-301, 19 publications on Rett syndrome 302-320 and 21 clinicaltreatment studies 321-341. Neuroinflammation or brain immune dysregulation were implicated in ASD in 52 clinical studies 342-393 and 13 review articles 394-406. Gastrointestinal (GI) inflammation or immune dysregulation were implicated in ASD in 24 clinical studies 407-430 and 7 review articles 431-437. Ninety-five publications 438-532 (not included in the initial 437 publications) discussed a possible link between vaccines (mainly MMR vaccine) and immune dysregulation and/or inflammation (especially of the GI tract) in ASD and were not included in this analysis; the majority of these 95 publications reported no significant association. 1 Oxidative stress A total of 115 publications investigated a relationship between oxidative stress and ASD, with all 115 implicating an association. These publications included 51 clinical studies 22, 27, 32, 40, 88, 119, 120, 150, 173, 337, 345, 346, 354, 533-570 , 41 review articles or hypothesis-generating papers 184, 188, 190, 194, 200, 203, 204, 206-208, 215, 221, 239, 253-255, 402, 405, 571-593 , 7 clinical-treatment studies 322, 594-599, 6 publications reporting animal models 283, 600-604 and 10 publications on Rett syndrome 605-614. Mitochondrial dysfunction A total of 153 publications investigated a relationship between mitochondrial dysfunction and ASD or Rett syndrome, with 145 implicating a relationship and 8 publications (all clinical studies) failing to find an association between mitochondrial dysfunction and ASD 615-621 or Rett syndrome 622. The 145 publications implicating an association between mitochondrial dysfunction and ASD included 63 clinical studies 32, 108, 172, 536, 539, 541, 552, 558, 569, 570, 623-675, 22 review articles or hypothesis-generating papers 200, 203, 204, 207, 208, 215, 253, 254, 402, 573, 578, 591, 676-685, 11 publications reporting animal models 283, 296, 297, 602, 686-692 and 49 studies of Rett syndrome 306, 607610, 613, 693-735 . Environmental toxicant exposures 2 A total of 190 publications investigated a relationship between environmental toxicant exposures (such as pesticides, chemicals, phthalates, PCBs, solvents, heavy metals or other pollutants) and ASD, with 170 implicating a relationship and 20 publications (19 clinical studies and 1 letter to the editor) 3, 15, 151, 736-752 failing to find an association between environmental toxicant exposures and ASD. The 170 publications implicating an association between environmental toxicant exposures and ASD included 71 clinical studies 35, 66, 157, 159, 322, 379, 386, 387, 412, 516, 533, 537, 541, 545, 546, 552, 561, 567, 594, 623, 753-803 , 67 review articles or hypothesis-generating papers 180, 182, 186-188, 192, 194, 203-205, 207, 215, 222, 225, 233, 234, 250, 402, 437, 573, 575, 578, 579, 583, 585, 587, 804-844 , 26 publications of animal models 270, 277, 278, 283, 293, 296, 600, 602, 845-862 and 6 clinical studies on treatments for toxicants 863-868. Forty-seven publications (not included in the initial 190 publications) examined a possible association between thimerosal (ethylmercury) in vaccines and ASD, with 37 publications reporting no significant association 21, 447, 449, 459, 462, 481, 497, 498, 869-897 and 10 (all but one publication were from the same authors) reporting some type of an association 457, 898-906. No publications reported an association or lack of an association between environmental toxicant exposures and Rett syndrome. 3 References 1. Hornig M, Briese T, Buie T, Bauman ML, Lauwers G, Siemetzki U et al. Lack of association between measles virus vaccine and autism with enteropathy: a case-control study. PLoS ONE 2008; 3(9): e3140. 2. Croen LA, Goines P, Braunschweig D, Yolken R, Yoshida CK, Grether JK et al. Brainderived neurotrophic factor and autism: maternal and infant peripheral blood levels in the Early Markers for Autism (EMA) Study. Autism Res 2008; 1(2): 130-137. 3. Rosen NJ, Yoshida CK, Croen LA. Infection in the first 2 years of life and autism spectrum disorders. Pediatrics 2007; 119(1): e61-69. 4. Sweeten TL, Taylor MW, Posey DJ, McDougle CJ. Plasma kynurenine levels in autistic disorder. Journal of Developmental and Physical Disabilities 2006; 18(4): 419-426. 5. Robertson MA, Sigalet DL, Holst JJ, Meddings JB, Wood J, Sharkey KA. Intestinal permeability and glucagon-like peptide-2 in children with autism: a controlled pilot study. J Autism Dev Disord 2008; 38(6): 1066-1071. 6. Goines P, Schauer J, Heuer L, Ashwood P, Van de Water J. Beta-2-microglobulin in autism spectrum disorders. American Journal of Biochemistry and Biotechnology 2007; 3(2): 87-91. 7. Abolfazli R, Mirbagheri SA, Zabihi AA, Abouzari M. Autism and celiac disease: Failure to validate the hypothesis of a possible link. Iranian Red Crescent Medical Journal 2009; 11(4): 442-444. 8. Cook EH, Jr., Perry BD, Dawson G, Wainwright MS, Leventhal BL. Receptor inhibition by immunoglobulins: specific inhibition by autistic children, their relatives, and control subjects. J Autism Dev Disord 1993; 23(1): 67-78. 9. Handen BL, Melmed RD, Hansen RL, Aman MG, Burnham DL, Bruss JB et al. A double-blind, placebo-controlled trial of oral human immunoglobulin for gastrointestinal dysfunction in children with autistic disorder. J Autism Dev Disord 2009; 39(5): 796-805. 10. Satterfield BC, Garcia RA, Gurrieri F, Schwartz CE. PCR and serology find no association between xenotropic murine leukemia virus-related virus (XMRV) and autism. Mol Autism 2010; 1(1): 14. 11. Black C, Kaye JA, Jick H. Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database. BMJ 2002; 325(7361): 419-421. 4 12. Fernell E, Fagerberg UL, Hellstrom PM. No evidence for a clear link between active intestinal inflammation and autism based on analyses of faecal calprotectin and rectal nitric oxide. Acta Paediatr 2007; 96(7): 1076-1079. 13. Croen LA, Matevia M, Yoshida CK, Grether JK. Maternal Rh D status, anti-D immune globulin exposure during pregnancy, and risk of autism spectrum disorders. Am J Obstet Gynecol 2008; 199(3): 234 e231-236. 14. DeFelice ML, Ruchelli ED, Markowitz JE, Strogatz M, Reddy KP, Kadivar K et al. Intestinal cytokines in children with pervasive developmental disorders. Am J Gastroenterol 2003; 98(8): 1777-1782. 15. Singh VK, Hanson J. Assessment of metallothionein and antibodies to metallothionein in normal and autistic children having exposure to vaccine-derived thimerosal. Pediatr Allergy Immunol 2006; 17(4): 291-296. 16. Kirkman NJ, Libbey JE, Sweeten TL, Coon HH, Miller JN, Stevenson EK et al. How relevant are GFAP autoantibodies in autism and Tourette Syndrome? J Autism Dev Disord 2008; 38(2): 333-341. 17. Libbey JE, Coon HH, Kirkman NJ, Sweeten TL, Miller JN, Stevenson EK et al. Are there enhanced MBP autoantibodies in autism? J Autism Dev Disord 2008; 38(2): 324332. 18. Morris CM, Zimmerman AW, Singer HS. Childhood serum anti-fetal brain antibodies do not predict autism. Pediatr Neurol 2009; 41(4): 288-290. 19. Anlar B, Oktem F, Torok T. Human parvovirus B19 antibodies in infantile autism. J Child Neurol 1994; 9(1): 104-105. 20. Atladottir HO, Thorsen P, Schendel DE, Ostergaard L, Lemcke S, Parner ET. Association of hospitalization for infection in childhood with diagnosis of autism spectrum disorders: a Danish cohort study. Arch Pediatr Adolesc Med 2010; 164(5): 470-477. 21. Singh VK, Rivas WH. Detection of antinuclear and antilaminin antibodies in autistic children who received thimerosal-containing vaccines. J Biomed Sci 2004; 11(5): 607610. 22. Yao Y, Walsh WJ, McGinnis WR, Pratico D. Altered vascular phenotype in autism: correlation with oxidative stress. Arch Neurol 2006; 63(8): 1161-1164. 23. Williams G, McChane RH, Schikler K. Case Report: 6-Year-Old Male with Autism and Systemic Onset Juvenile Rheumatoid Arthritis. Journal of Developmental and Physical Disabilities 2004; 16(1): 117-123. 5 24. Wiest MM, German JB, Harvey DJ, Watkins SM, Hertz-Picciotto I. Plasma fatty acid profiles in autism: a case-control study. Prostaglandins Leukot Essent Fatty Acids 2009; 80(4): 221-227. 25. Tani P, Lindberg N, Matto V, Appelberg B, Nieminen-von Wendt T, von Wendt L et al. Higher plasma ACTH levels in adults with Asperger syndrome. J Psychosom Res 2005; 58(6): 533-536. 26. Suzuki K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ et al. Decreased serum levels of epidermal growth factor in adult subjects with high-functioning autism. Biol Psychiatry 2007; 62(3): 267-269. 27. Suh JH, Walsh WJ, McGinnis WR, Lewis A, Ames BN. Altered sulfur amino acid metabolism in immune cells of children diagnosed with autism American Journal of Biochemistry and Biotechnology 2008; 4(2): 105-113. 28. Sugihara G, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ et al. Decreased serum levels of hepatocyte growth factor in male adults with high-functioning autism. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31(2): 412-415. 29. Sokol DK, Chen D, Farlow MR, Dunn DW, Maloney B, Zimmer JA et al. High levels of Alzheimer beta-amyloid precursor protein (APP) in children with severely autistic behavior and aggression. J Child Neurol 2006; 21(6): 444-449. 30. Shinohe A, Hashimoto K, Nakamura K, Tsujii M, Iwata Y, Tsuchiya KJ et al. Increased serum levels of glutamate in adult patients with autism. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30(8): 1472-1477. 31. Russo AJ. Anti-metallothionein IgG and levels of metallothionein in autistic children with GI disease. Drug, Healthcare and Patient Safety 2009; 1(1): 1-8. 32. Pastural E, Ritchie S, Lu Y, Jin W, Kavianpour A, Khine Su-Myat K et al. Novel plasma phospholipid biomarkers of autism: mitochondrial dysfunction as a putative causative mechanism. Prostaglandins Leukot Essent Fatty Acids 2009; 81(4): 253-264. 33. Okada K, Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ et al. Decreased serum levels of transforming growth factor-beta1 in patients with autism. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31(1): 187-190. 34. Odell D, Maciulis A, Cutler A, Warren L, McMahon WM, Coon H et al. Confirmation of the association of the C4B null allelle in autism. Hum Immunol 2005; 66(2): 140-145. 35. Nicolson GL, Gan R, Nicolson NL, Haier J. Evidence for Mycoplasma ssp., Chlamydia pneunomiae, and human herpes virus-6 coinfections in the blood of patients with autistic spectrum disorders. J Neurosci Res 2007; 85(5): 1143-1148. 6 36. Nelson KB, Grether JK, Croen LA, Dambrosia JM, Dickens BF, Jelliffe LL et al. Neuropeptides and neurotrophins in neonatal blood of children with autism or mental retardation. Ann Neurol 2001; 49(5): 597-606. 37. Mostafa GA, Hamza RT, El-Shahawi HH. Allergic manifestations in autistic children: Relation to disease severity. Journal of Pediatric Neurology 2008; 6(2): 115-123. 38. Mostafa GA, El-Sherif DF, Hamza RT, Al Shehab A. Hyperserotonemia in Egyptian autistic children: Relation to allergic manifestations. Journal of Pediatric Neurology 2008; 6(3): 227-236. 39. Momeni N, Nordstrom BM, Horstmann V, Avarseji H, Sivberg BV. Alterations of prolyl endopeptidase activity in the plasma of children with autistic spectrum disorders. BMC Psychiatry 2005; 5: 27. 40. Karamouzi A, Kovachev D, Karamouzis I, Antoniadou-Hitoglou M, Tsikoulas I, Aggelopoulou-Sakadami N. Saliva levels of 15-F2t-Isoprostane as biomarker of lipid peroxidation in autistic children. European Journal of Inflammation 2007; 5(3): 141-144. 41. Kajizuka M, Miyachi T, Matsuzaki H, Iwata K, Shinmura C, Suzuki K et al. Serum levels of platelet-derived growth factor BB homodimers are increased in male children with autism. Prog Neuropsychopharmacol Biol Psychiatry 2009. 42. Hashimoto K, Iwata Y, Nakamura K, Tsujii M, Tsuchiya KJ, Sekine Y et al. Reduced serum levels of brain-derived neurotrophic factor in adult male patients with autism. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30(8): 1529-1531. 43. Cazzullo AG, Musetti MC, Musetti L, Bajo S, Sacerdote P, Panerai A. Beta-endorphin levels in peripheral blood mononuclear cells and long-term naltrexone treatment in autistic children. Eur Neuropsychopharmacol 1999; 9(4): 361-366. 44. Bell JG, Miller D, MacDonald DJ, MacKinlay EE, Dick JR, Cheseldine S et al. The fatty acid compositions of erythrocyte and plasma polar lipids in children with autism, developmental delay or typically developing controls and the effect of fish oil intake. Br J Nutr 2010; 103(8): 1160-1167. 45. Fujita-Shimizu A, Suzuki K, Nakamura K, Miyachi T, Matsuzaki H, Kajizuka M et al. Decreased serum levels of adiponectin in subjects with autism. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34(3): 455-458. 46. Fatemi SH, Stary JM, Egan EA. Reduced blood levels of reelin as a vulnerability factor in pathophysiology of autistic disorder. Cell Mol Neurobiol 2002; 22(2): 139-152. 7 47. Enstrom A, Onore C, Tarver A, Hertz-Picciotto I, Hansen R, Croen L et al. Peripheral blood leukocyte production of BDNF following mitogen stimulation in early onset and regressive autism. American Journal of Biochemistry and Biotechnology 2008; 4(2): 121129. 48. Enstrom A, Onore C, Hertz-Picciotto I, Hansen R, Croen L, Van de Water J et al. Detection of IL-17 and IL-23 in plasma samples of children with autism. Am J Biochem Biotech 2008; 4(2): 114-120. 49. Engstrom HA, Ohlson S, Stubbs EG, Maciulis A, Caldwell V, Odell JD et al. Decreased Expression of CD95 (FAS/APO-1) on CD4+ T-lymphocytes from Participants with Autism. Journal of Developmental and Physical Disabilities 2003; 15(2): 155-163. 50. Curran LK, Newschaffer CJ, Lee LC, Crawford SO, Johnston MV, Zimmerman AW. Behaviors associated with fever in children with autism spectrum disorders. Pediatrics 2007; 120(6): e1386-1392. 51. Corbett BA, Kantor AB, Schulman H, Walker WL, Lit L, Ashwood P et al. A proteomic study of serum from children with autism showing differential expression of apolipoproteins and complement proteins. Mol Psychiatry 2007; 12(3): 292-306. 52. Bu B, Ashwood P, Harvey D, King IB, Water JV, Jin LW. Fatty acid compositions of red blood cell phospholipids in children with autism. Prostaglandins Leukot Essent Fatty Acids 2006; 74(4): 215-221. 53. Brambilla F, Guareschi-Cazzullo A, Tacchini C, Musetti C, Panerai AE, Sacerdote P. Beta-endorphin and cholecystokinin 8 concentrations in peripheral blood mononuclear cells of autistic children. Neuropsychobiology 1997; 35(1): 1-4. 54. Boris M, Goldblatt A. Pollen exposure as a cause for the deterioration of neurobehavioral function in children with autism and attention deficit hyperactive disorder: Nasal pollen challenge. J Nutritional Environmental Medicine 2004; 14(1): 47-54. 55. Atladottir HO, Thorsen P, Ostergaard L, Schendel DE, Lemcke S, Abdallah M et al. Maternal Infection Requiring Hospitalization During Pregnancy and Autism Spectrum Disorders. J Autism Dev Disord 2010. 56. Anlar B, Oktem F, Bakkaloglu B, Haliloglu M, Oguz H, Unal F et al. Urinary epidermal and insulin-like growth factor excretion in autistic children. Neuropediatrics 2007; 38(3): 151-153. 57. Al-Ayadhi LY. Pro-inflammatory cytokines in autistic children in central Saudi Arabia. Neurosciences 2005; 10(2): 155-158. 8 58. Al-Ayadhi LY. Autoimmune connection of autism in Central Saudi Arabia. Neurosciences 2005; 10(4): 265-267. 59. Angelidou A, Francis K, Vasiadi M, Alysandratos KD, Zhang B, Theoharides A et al. Neurotensin is increased in serum of young children with autistic disorder. J Neuroinflammation 2010; 7(1): 48. 60. Ashwood P, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen RL, Croen LA et al. Decreased transforming growth factor beta1 in autism: A potential link between immune dysregulation and impairment in clinical behavioral outcomes. J Neuroimmunol 2008. 61. Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah I, Van de Water J. Elevated plasma cytokines in autism spectrum disorders provide evidence of immune dysfunction and are associated with impaired behavioral outcome. Brain Behav Immun 2010. 62. Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J. Altered T cell responses in children with autism. Brain Behav Immun 2010. 63. Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Pessah IN, Van de Water J. Associations of impaired behaviors with elevated plasma chemokines in autism spectrum disorders. J Neuroimmunol 2010. 64. Ashwood P, Kwong C, Hansen R, Hertz-Picciotto I, Croen L, Krakowiak P et al. Brief report: Plasma leptin levels are elevated in autism: Association with early onset phenotype? J Autism Dev Disord 2008; 38(1): 169-175. 65. Ashwood P, Nguyen DV, Hessl D, Hagerman RJ, Tassone F. Plasma cytokine profiles in Fragile X subjects: is there a role for cytokines in the pathogenesis? Brain Behav Immun 2010; 24(6): 898-902. 66. Ashwood P, Schauer J, Pessah IN, de Water JV. Preliminary evidence of the in vitro effects of BDE-47 on innate immune responses in children with autism spectrum disorders. J Neuroimmunol 2009; 208(1-2): 130-135. 67. Atladottir HO, Pedersen MG, Thorsen P, Mortensen PB, Deleuran B, Eaton WW et al. Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics 2009; 124(2): 687-694. 68. Bakkaloglu B, Anlar B, Anlar FY, Oktem F, Pehlivanturk B, Unal F et al. Atopic features in early childhood autism. Eur J Paediatr Neurol 2008. 69. Bidet B, Leboyer M, Descours B, Bouvard MP, Benveniste J. Allergic sensitization in infantile autism. J Autism Dev Disord 1993; 23(2): 419-420. 9 70. Blardi P, de Lalla A, Ceccatelli L, Vanessa G, Auteri A, Hayek J. Variations of plasma leptin and adiponectin levels in autistic patients. Neurosci Lett 2010; 479(1): 54-57. 71. Campbell DB, D'Oronzio R, Garbett K, Ebert PJ, Mirnics K, Levitt P et al. Disruption of cerebral cortex MET signaling in autism spectrum disorder. Ann Neurol 2007; 62(3): 243-250. 72. Campbell DB, Sutcliffe JS, Ebert PJ, Militerni R, Bravaccio C, Trillo S et al. A genetic variant that disrupts MET transcription is associated with autism. Proc Natl Acad Sci U S A 2006; 103(45): 16834-16839. 73. Chen CP, Lin SP, Chern SR, Tsai FJ, Wu PC, Lee CC et al. A de novo 7.9 Mb deletion in 22q13.2-->qter in a boy with autistic features, epilepsy, developmental delay, atopic dermatitis and abnormal immunological findings. Eur J Med Genet 2010; 53(5): 329332. 74. Comi AM, Zimmerman AW, Frye VH, Law PA, Peeden JN. Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. J Child Neurol 1999; 14(6): 388-394. 75. Croen LA, Grether JK, Yoshida CK, Odouli R, Van de Water J. Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study. Arch Pediatr Adolesc Med 2005; 159(2): 151-157. 76. Croonenberghs J, Bosmans E, Deboutte D, Kenis G, Maes M. Activation of the inflammatory response system in autism. Neuropsychobiology 2002; 45(1): 1-6. 77. Croonenberghs J, Wauters A, Devreese K, Verkerk R, Scharpe S, Bosmans E et al. Increased serum albumin, gamma globulin, immunoglobulin IgG, and IgG2 and IgG4 in autism. Psychol Med 2002; 32(8): 1457-1463. 78. Daniels WW, Warren RP, Odell JD, Maciulis A, Burger RA, Warren WL et al. Increased frequency of the extended or ancestral haplotype B44-SC30-DR4 in autism. Neuropsychobiology 1995; 32(3): 120-123. 79. Denney DR, Frei BW, Gaffney GR. Lymphocyte subsets and interleukin-2 receptors in autistic children. J Autism Dev Disord 1996; 26(1): 87-97. 80. Emanuele E, Orsi P, Boso M, Broglia D, Brondino N, Barale F et al. Low-grade endotoxemia in patients with severe autism. Neurosci Lett 2010; 471(3): 162-165. 81. Emanuele E, Boso M, Brondino N, Pietra S, Barale F, Ucelli di Nemi S et al. Increased serum levels of high mobility group box 1 protein in patients with autistic disorder. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34(4): 681-683. 10 82. Enstrom AM, Lit L, Onore CE, Gregg JP, Hansen RL, Pessah IN et al. Altered gene expression and function of peripheral blood natural killer cells in children with autism. Brain Behav Immun 2008. 83. Enstrom AM, Onore CE, Van de Water JA, Ashwood P. Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain Behav Immun 2010; 24(1): 64-71. 84. Enstrom A, Krakowiak P, Onore C, Pessah IN, Hertz-Picciotto I, Hansen RL et al. Increased IgG4 levels in children with autism disorder. Brain Behav Immun 2009; 23(3): 389-395. 85. Evers M, Cunningham-Rundles C, Hollander E. Heat shock protein 90 antibodies in autism. Mol Psychiatry 2002; 7 Suppl 2: S26-28. 86. Ferrante P, Saresella M, Guerini FR, Marzorati M, Musetti MC, Cazzullo AG. Significant association of HLA A2-DR11 with CD4 naive decrease in autistic children. Biomed Pharmacother 2003; 57(8): 372-374. 87. Ferrari P, Marescot MR, Moulias R, Bursztejn C, Deville Chabrolle A, Thiollet M et al. [Immune status in infantile autism. Correlation between the immune status, autistic symptoms and levels of serotonin]. Encephale 1988; 14(5): 339-344. 88. Frye RE. Central tetrahydrobiopterin concentration in neurodevelopmental disorders. Front Neurosci 2010; 4: 52. 89. Geier DA, Geier MR. A prospective study of thimerosal-containing Rho(D)-immune globulin administration as a risk factor for autistic disorders. J Matern Fetal Neonatal Med 2007; 20(5): 385-390. 90. Geier DA, Mumper E, Gladfelter B, Coleman L, Geier MR. Neurodevelopmental disorders, maternal Rh-negativity, and Rho(D) immune globulins: a multi-center assessment. Neuro Endocrinol Lett 2008; 29(2): 272-280. 91. Giuliodori K, Ganzetti G, Campanati A, Simonetti O, Marconi B, Offidani A. A nonresponsive chronic autoimmune urticaria in a 12-year-old autistic girl treated with cyclosporin. J Eur Acad Dermatol Venereol 2009; 23(5): 619-620. 92. Grether JK, Croen LA, Anderson MC, Nelson KB, Yolken RH. Neonatally measured immunoglobulins and risk of autism. Autism Res 2010. 93. Grigorenko EL, Han SS, Yrigollen CM, Leng L, Mizue Y, Anderson GM et al. Macrophage migration inhibitory factor and autism spectrum disorders. Pediatrics 2008; 122(2): e438-445. 11 94. Gupta S, Aggarwal S, Rashanravan B, Lee T. Th1- and Th2-like cytokines in CD4+ and CD8+ T cells in autism. J Neuroimmunol 1998; 85(1): 106-109. 95. Harrison KL, Pheasant AE. Analysis of urinary pterins in autism. Biochem Soc Trans 1995; 23(4): 603S. 96. Heuer L, Ashwood P, Schauer J, Goines P, Krakowiak P, Hertz-Picciotto I et al. Reduced levels of immunoglobulin in children with autism correlates with behavioral symptoms. Autism Res 2008; 1(5): 275-283. 97. Hollander E, DelGiudice-Asch G, Simon L, Schmeidler J, Cartwright C, DeCaria CM et al. B lymphocyte antigen D8/17 and repetitive behaviors in autism. Am J Psychiatry 1999; 156(2): 317-320. 98. Hu VW, Nguyen A, Kim KS, Steinberg ME, Sarachana T, Scully MA et al. Gene expression profiling of lymphoblasts from autistic and nonaffected sib pairs: altered pathways in neuronal development and steroid biosynthesis. PLoS One 2009; 4(6): e5775. 99. Hunter LC, O'Hare A, Herron WJ, Fisher LA, Jones GE. Opioid peptides and dipeptidyl peptidase in autism. Dev Med Child Neurol 2003; 45(2): 121-128. 100. Iseri E, Guney E, Ceylan MF, Yucel A, Aral A, Bodur S et al. Increased Serum Levels of Epidermal Growth Factor in Children with Autism. J Autism Dev Disord 2010. 101. Iwata Y, Tsuchiya KJ, Mikawa S, Nakamura K, Takai Y, Suda S et al. Serum levels of Pselectin in men with high-functioning autism. Br J Psychiatry 2008; 193(4): 338-339. 102. Jyonouchi H. Autism spectrum disorders and allergy: observation from a pediatric allergy/immunology clinic. Expert Rev Clin Immunol 2010; 6(3): 397-411. 103. Jyonouchi H, Geng L, Cushing-Ruby A, Quraishi H. Impact of innate immunity in a subset of children with autism spectrum disorders: a case control study. J Neuroinflammation 2008; 5: 52. 104. Jyonouchi H, Sun S, Itokazu N. Innate immunity associated with inflammatory responses and cytokine production against common dietary proteins in patients with autism spectrum disorder. Neuropsychobiology 2002; 46(2): 76-84. 105. Jyonouchi H, Sun S, Le H. Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression. J Neuroimmunol 2001; 120(1-2): 170-179. 106. Kawashti MI, Amin OR, Rowehy NG. Possible immunological disorders in autism: concomitant autoimmunity and immune tolerance. Egypt J Immunol 2006; 13(1): 99-104. 12 107. Keil A, Daniels JL, Forssen U, Hultman C, Cnattingius S, Soderberg KC et al. Parental Autoimmune Diseases Associated With Autism Spectrum Disorders in Offspring. Epidemiology 2010. 108. Kurup RK, Kurup PA. A hypothalamic digoxin-mediated model for autism. Int J Neurosci 2003; 113(11): 1537-1559. 109. Lee LC, Zachary AA, Leffell MS, Newschaffer CJ, Matteson KJ, Tyler JD et al. HLADR4 in families with autism. Pediatr Neurol 2006; 35(5): 303-307. 110. Lucarelli S, Frediani T, Zingoni AM, Ferruzzi F, Giardini O, Quintieri F et al. Food allergy and infantile autism. Panminerva Med 1995; 37(3): 137-141. 111. Magalhaes ES, Pinto-Mariz F, Bastos-Pinto S, Pontes AT, Prado EA, deAzevedo LC. Immune allergic response in Asperger syndrome. J Neuroimmunol 2009; 216(1-2): 108112. 112. Malik M, Sheikh AM, Wen G, Spivack W, Brown WT, Li X. Expression of inflammatory cytokines, Bcl2 and cathepsin D are altered in lymphoblasts of autistic subjects. Immunobiology 2010. 113. Matarazzo EB. Treatment of late onset autism as a consequence of probable autommune processes related to chronic bacterial infection. World J Biol Psychiatry 2002; 3(3): 162166. 114. Melin M, Carlsson B, Anckarsater H, Rastam M, Betancur C, Isaksson A et al. Constitutional downregulation of SEMA5A expression in autism. Neuropsychobiology 2006; 54(1): 64-69. 115. Messahel S, Pheasant AE, Pall H, Ahmed-Choudhury J, Sungum-Paliwal RS, Vostanis P. Urinary levels of neopterin and biopterin in autism. Neurosci Lett 1998; 241(1): 17-20. 116. Molloy CA, Morrow AL, Meinzen-Derr J, Dawson G, Bernier R, Dunn M et al. Familial autoimmune thyroid disease as a risk factor for regression in children with Autism Spectrum Disorder: a CPEA Study. J Autism Dev Disord 2006; 36(3): 317-324. 117. Molloy CA, Morrow AL, Meinzen-Derr J, Schleifer K, Dienger K, Manning-Courtney P et al. Elevated cytokine levels in children with autism spectrum disorder. J Neuroimmunol 2006; 172(1-2): 198-205. 118. Money J, Bobrow NA, Clarke FC. Autism and autoimmune disease: a family study. J Autism Child Schizophr 1971; 1(2): 146-160. 13 119. Morris CR, Agin MC. Syndrome of allergy, apraxia, and malabsorption: characterization of a neurodevelopmental phenotype that responds to omega 3 and vitamin E supplementation. Altern Ther Health Med 2009; 15(4): 34-43. 120. Mostafa GA, El-Hadidi ES, Hewedi DH, Abdou MM. Oxidative stress in Egyptian children with autism: relation to autoimmunity. J Neuroimmunol 2009. 121. Mostafa GA, Shehab AA. The link of C4B null allele to autism and to a family history of autoimmunity in Egyptian autistic children. J Neuroimmunol 2010. 122. Mostafa GA, Al Shehab A, Fouad NR. Frequency of CD4+CD25high regulatory T cells in the peripheral blood of Egyptian children with autism. J Child Neurol 2010; 25(3): 328-335. 123. Mostafa GA, Kitchener N. Serum anti-nuclear antibodies as a marker of autoimmunity in Egyptian autistic children. Pediatr Neurol 2009; 40(2): 107-112. 124. Mouridsen SE, Rich B, Isager T, Nedergaard NJ. Autoimmune diseases in parents of children with infantile autism: a case-control study. Dev Med Child Neurol 2007; 49(6): 429-432. 125. Nelson PG, Kuddo T, Song EY, Dambrosia JM, Kohler S, Satyanarayana G et al. Selected neurotrophins, neuropeptides, and cytokines: developmental trajectory and concentrations in neonatal blood of children with autism or Down syndrome. Int J Dev Neurosci 2006; 24(1): 73-80. 126. Onore C, Enstrom A, Krakowiak P, Hertz-Picciotto I, Hansen R, Van de Water J et al. Decreased cellular IL-23 but not IL-17 production in children with autism spectrum disorders. J Neuroimmunol 2009; 216(1-2): 126-129. 127. Persico AM, Militerni R, Bravaccio C, Schneider C, Melmed R, Trillo S et al. Adenosine deaminase alleles and autistic disorder: case-control and family-based association studies. Am J Med Genet 2000; 96(6): 784-790. 128. Plioplys AV, Greaves A, Kazemi K, Silverman E. Lymphocyte function in autism and Rett syndrome. Neuropsychobiology 1994; 29(1): 12-16. 129. Russo AF. Anti-metallothionein IgG and levels of metallothionein in autistic families. Swiss Med Wkly 2008; 138(5-6): 70-77. 130. Russo AJ, Krigsman A, Jepson B, Wakefield A. Decreased Serum Hepatocyte Growth Factor (HGF) in Autistic Children with Severe Gastrointestinal Disease. Biomark Insights 2009; 4: 181-190. 14 131. Sacco R, Militerni R, Frolli A, Bravaccio C, Gritti A, Elia M et al. Clinical, morphological, and biochemical correlates of head circumference in autism. Biol Psychiatry 2007; 62(9): 1038-1047. 132. Sacco R, Curatolo P, Manzi B, Militerni R, Bravaccio C, Frolli A et al. Principal pathogenetic components and biological endophenotypes in autism spectrum disorders. Autism Res 2010; 3(5): 237-252. 133. Santaella ML, Varela Y, Linares N, Disdier OM. Prevalence of autism spectrum disorders in relatives of patients with selective immunoglobulin A deficiency. P R Health Sci J 2008; 27(3): 204-208. 134. Saresella M, Marventano I, Guerini FR, Mancuso R, Ceresa L, Zanzottera M et al. An autistic endophenotype results in complex immune dysfunction in healthy siblings of autistic children. Biol Psychiatry 2009; 66(10): 978-984. 135. Singh VK. Plasma increase of interleukin-12 and interferon-gamma. Pathological significance in autism. J Neuroimmunol 1996; 66(1-2): 143-145. 136. Singh VK, Jensen RL. Elevated levels of measles antibodies in children with autism. Pediatr Neurol 2003; 28(4): 292-294. 137. Singh VK, Singh EA, Warren RP. Hyperserotoninemia and serotonin receptor antibodies in children with autism but not mental retardation. Biol Psychiatry 1997; 41(6): 753-755. 138. Singh VK, Warren RP, Odell JD, Cole P. Changes of soluble interleukin-2, interleukin-2 receptor, T8 antigen, and interleukin-1 in the serum of autistic children. Clin Immunol Immunopathol 1991; 61(3): 448-455. 139. Sliwinski S, Croonenberghs J, Christophe A, Deboutte D, Maes M. Polyunsaturated fatty acids: do they have a role in the pathophysiology of autism? Neuro Endocrinol Lett 2006; 27(4): 465-471. 140. Spiroski M, Trajkovski V, Trajkov D, Petlichkovski A, Efinska-Mladenovska O, Hristomanova S et al. Family analysis of immunoglobulin classes and subclasses in children with autistic disorder. Bosn J Basic Med Sci 2009; 9(4): 283-289. 141. Stern L, Francoeur MJ, Primeau MN, Sommerville W, Fombonne E, Mazer BD. Immune function in autistic children. Ann Allergy Asthma Immunol 2005; 95(6): 558-565. 142. Stubbs EG. Autistic children exhibit undetectable hemagglutination-inhibition antibody titers despite previous rubella vaccination. J Autism Child Schizophr 1976; 6(3): 269-274. 143. Stubbs EG, Crawford ML. Depressed lymphocyte responsiveness in autistic children. J Autism Child Schizophr 1977; 7(1): 49-55. 15 144. Stubbs EG, Magenis RE. HLA and autism. J Autism Dev Disord 1980; 10(1): 15-19. 145. Stubbs EG, Ritvo ER, Mason-Brothers A. Autism and shared parental HLA antigens. J Am Acad Child Psychiatry 1985; 24(2): 182-185. 146. Stubbs G. Interferonemia and autism. J Autism Dev Disord 1995; 25(1): 71-73. 147. Sweeten TL, Bowyer SL, Posey DJ, Halberstadt GM, McDougle CJ. Increased prevalence of familial autoimmunity in probands with pervasive developmental disorders. Pediatrics 2003; 112(5): e420. 148. Sweeten TL, Posey DJ, McDougle CJ. High blood monocyte counts and neopterin levels in children with autistic disorder. Am J Psychiatry 2003; 160(9): 1691-1693. 149. Sweeten TL, Posey DJ, McDougle CJ. Brief report: autistic disorder in three children with cytomegalovirus infection. J Autism Dev Disord 2004; 34(5): 583-586. 150. Sweeten TL, Posey DJ, Shankar S, McDougle CJ. High nitric oxide production in autistic disorder: a possible role for interferon-gamma. Biol Psychiatry 2004; 55(4): 434-437. 151. Tian Y, Green PG, Stamova B, Hertz-Picciotto I, Pessah IN, Hansen R et al. Correlations of Gene Expression with Blood Lead Levels in Children with Autism Compared to Typically Developing Controls. Neurotox Res 2009. 152. Torres AR, Maciulis A, Stubbs EG, Cutler A, Odell D. The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder. Hum Immunol 2002; 63(4): 311-316. 153. Torres AR, Sweeten TL, Cutler A, Bedke BJ, Fillmore M, Stubbs EG et al. The association and linkage of the HLA-A2 class I allele with autism. Hum Immunol 2006; 67(4-5): 346-351. 154. Trajkovski V, Ajdinski L, Spiroski M. Plasma concentration of immunoglobulin classes and subclasses in children with autism in the Republic of Macedonia: retrospective study. Croat Med J 2004; 45(6): 746-749. 155. Tsuchiya KJ, Hashimoto K, Iwata Y, Tsujii M, Sekine Y, Sugihara G et al. Decreased serum levels of platelet-endothelial adhesion molecule (PECAM-1) in subjects with highfunctioning autism: a negative correlation with head circumference at birth. Biol Psychiatry 2007; 62(9): 1056-1058. 156. Verdot L, Garreau B, Barthelemy C, Martineau J, Ferrer-Di-Martino M, Muh JP et al. Immunoreactivity of sera to a peptide derived from the serotonin 5-HT1A receptor in a 16 group of children with developmental disorders: possible role in non-autistic epilepsy. Int J Mol Med 1998; 1(1): 185-189. 157. Vojdani A, Bazargan M, Vojdani E, Samadi J, Nourian AA, Eghbalieh N et al. Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease. Clin Diagn Lab Immunol 2004; 11(3): 515-524. 158. Vojdani A, Mumper E, Granpeesheh D, Mielke L, Traver D, Bock K et al. Low natural killer cell cytotoxic activity in autism: The role of glutathione, IL-2 and IL-15. J Neuroimmunol 2008; 205(1-2): 148-154. 159. Vojdani A, Pangborn JB, Vojdani E, Cooper EL. Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism. Int J Immunopathol Pharmacol 2003; 16(3): 189-199. 160. Warren RP, Burger RA, Odell D, Torres AR, Warren WL. Decreased plasma concentrations of the C4B complement protein in autism. Arch Pediatr Adolesc Med 1994; 148(2): 180-183. 161. Warren RP, Cole P, Odell JD, Pingree CB, Warren WL, White E et al. Detection of maternal antibodies in infantile autism. J Am Acad Child Adolesc Psychiatry 1990; 29(6): 873-877. 162. Warren RP, Foster A, Margaretten NC. Reduced natural killer cell activity in autism. J Am Acad Child Adolesc Psychiatry 1987; 26(3): 333-335. 163. Warren RP, Margaretten NC, Pace NC, Foster A. Immune abnormalities in patients with autism. J Autism Dev Disord 1986; 16(2): 189-197. 164. Warren RP, Odell JD, Warren WL, Burger RA, Maciulis A, Daniels WW et al. Strong association of the third hypervariable region of HLA-DR beta 1 with autism. J Neuroimmunol 1996; 67(2): 97-102. 165. Warren RP, Odell JD, Warren WL, Burger RA, Maciulis A, Daniels WW et al. Brief report: immunoglobulin A deficiency in a subset of autistic subjects. J Autism Dev Disord 1997; 27(2): 187-192. 166. Warren RP, Singh VK. Elevated serotonin levels in autism: association with the major histocompatibility complex. Neuropsychobiology 1996; 34(2): 72-75. 167. Warren RP, Singh VK, Averett RE, Odell JD, Maciulis A, Burger RA et al. Immunogenetic studies in autism and related disorders. Mol Chem Neuropathol 1996; 28(1-3): 77-81. 17 168. Warren RP, Singh VK, Cole P, Odell JD, Pingree CB, Warren WL et al. Increased frequency of the null allele at the complement C4b locus in autism. Clin Exp Immunol 1991; 83(3): 438-440. 169. Warren RP, Yonk J, Burger RW, Odell D, Warren WL. DR-positive T cells in autism: association with decreased plasma levels of the complement C4B protein. Neuropsychobiology 1995; 31(2): 53-57. 170. Warren RP, Yonk LJ, Burger RA, Cole P, Odell JD, Warren WL et al. Deficiency of suppressor-inducer (CD4+CD45RA+) T cells in autism. Immunol Invest 1990; 19(3): 245-251. 171. Yonk LJ, Warren RP, Burger RA, Cole P, Odell JD, Warren WL et al. CD4+ helper T cell depression in autism. Immunol Lett 1990; 25(4): 341-345. 172. Zhang B, Angelidou A, Alysandratos KD, Vasiadi M, Francis K, Asadi S et al. Mitochondrial DNA and anti-mitochondrial antibodies in serum of autistic children. J Neuroinflammation 2010; 7(1): 80. 173. Zoroglu SS, Yurekli M, Meram I, Sogut S, Tutkun H, Yetkin O et al. Pathophysiological role of nitric oxide and adrenomedullin in autism. Cell Biochem Funct 2003; 21(1): 5560. 174. Gillberg IC, Gillberg C, Kopp S. Hypothyroidism and autism spectrum disorders. J Child Psychol Psychiatry 1992; 33(3): 531-542. 175. Napolioni V, Lombardi F, Sacco R, Curatolo P, Manzi B, Alessandrelli R et al. Familybased association study of ITGB3 in autism spectrum disorder and its endophenotypes. Eur J Hum Genet 2010. 176. Guerini FR, Bolognesi E, Manca S, Sotgiu S, Zanzottera M, Agliardi C et al. Familybased transmission analysis of HLA genetic markers in Sardinian children with autistic spectrum disorders. Hum Immunol 2009; 70(3): 184-190. 177. Torres AR, Maciulis A, Odell D. The association of MHC genes with autism. Front Biosci 2001; 6: D936-943. 178. Gupta S, Samra D, Agrawal S. Adaptive and Innate Immune Responses in Autism: Rationale for Therapeutic Use of Intravenous Immunoglobulin. J Clin Immunol 2010. 179. Liao P, Soong TW. Ca(V)1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency. Pflugers Arch 2009. 180. Kempuraj D, Asadi S, Zhang B, Manola A, Hogan J, Peterson E et al. Mercury induces inflammatory mediator release from human mast cells. J Neuroinflammation 2010; 7: 20. 18 181. Hertz-Picciotto I, Park HY, Dostal M, Kocan A, Trnovec T, Sram R. Prenatal exposures to persistent and non-persistent organic compounds and effects on immune system development. Basic Clin Pharmacol Toxicol 2008; 102(2): 146-154. 182. Herbert MR, Russo JP, Yang S, Roohi J, Blaxill M, Kahler SG et al. Autism and environmental genomics. Neurotoxicology 2006; 27(5): 671-684. 183. Warren RP. An immunologie theory for the development of some cases of autism. CNS Spectrums 1998; 3(3): 71-79. 184. Theoharides TC, Doyle R, Francis K, Conti P, Kalogeromitros D. Novel therapeutic targets for autism. Trends Pharmacol Sci 2008. 185. Theoharides TC, Doyle R. Autism, gut-blood-brain barrier, and mast cells. J Clin Psychopharmacol 2008; 28(5): 479-483. 186. Stigler KA, Sweeten TL, Posey DJ, McDougle CJ. Autism and immune factors: A comprehensive review. Research in Autism Spectrum Disorders 2009; 3(4): 840-860. 187. Prandota J. Neuropathological changes and clinical features of autism spectrum disorder participants are similar to that reported in congenital and chronic cerebral toxoplasmosis in humans and mice. Research in Autism Spectrum Disorders 2010; 4(2): 103-118. 188. Prandota J. Autism spectrum disorders may be due to cerebral toxoplasmosis associated with chronic neuroinflammation causing persistent hypercytokinemia that resulted in an increased lipid peroxidation, oxidative stress, and depressed metabolism of endogenous and exogenous substances. Research in Autism Spectrum Disorders 2010; 4(2): 119-155. 189. Pickett J, London E. The neuropathology of autism: a review. J Neuropathol Exp Neurol 2005; 64(11): 925-935. 190. Pardo CA, Eberhart CG. The neurobiology of autism. Brain Pathol 2007; 17(4): 434-447. 191. Burger RA, Warren RP. Possible immunogenetic basis for autism. Mental Retardation and Developmental Disabilities Research Reviews 1998; 4(2): 137-141. 192. Bransfield RC. Preventable cases of autism: Relationship between chronic infectious diseases and neurological outcome. Pediatric Health 2009; 3(2): 125-140. 193. Barak Y, Kimhi R, Stein D, Gutman J, Weizman A. Autistic subjects with comorbid epilepsy: a possible association with viral infections. Child Psychiatry Hum Dev 1999; 29(3): 245-251. 19 194. Anderson MP, Hooker BS, Herbert MR. Bridging from cells to cognition in autism pathophysiology: biological pathways to defective brain function and plasticity American Journal of Biochemistry and Biotechnology 2008; 4(2): 167-176. 195. Ashwood P, Van de Water J. Is autism an autoimmune disease? Autoimmun Rev 2004; 3(7-8): 557-562. 196. Ashwood P, Van de Water J. A review of autism and the immune response. Clin Dev Immunol 2004; 11(2): 165-174. 197. Ashwood P, Wills S, Van de Water J. The immune response in autism: a new frontier for autism research. J Leukoc Biol 2006; 80(1): 1-15. 198. Becker KG. Autism, asthma, inflammation, and the hygiene hypothesis. Med Hypotheses 2007; 69(4): 731-740. 199. Becker KG, Schultz ST. Similarities in features of autism and asthma and a possible link to acetaminophen use. Med Hypotheses 2009. 200. Bent S, Hendren RL. Improving the prediction of response to therapy in autism. Neurotherapeutics 2010; 7(3): 232-240. 201. Binstock T. Intra-monocyte pathogens delineate autism subgroups. Med Hypotheses 2001; 56(4): 523-531. 202. Blaylock RL. A possible central mechanism in autism spectrum disorders, part 1. Altern Ther Health Med 2008; 14(6): 46-53. 203. Blaylock RL. A possible central mechanism in autism spectrum disorders, part 2: immunoexcitotoxicity. Altern Ther Health Med 2009; 15(1): 60-67. 204. Blaylock RL. A possible central mechanism in autism spectrum disorders, part 3: the role of excitotoxin food additives and the synergistic effects of other environmental toxins. Altern Ther Health Med 2009; 15(2): 56-60. 205. Blaylock RL, Strunecka A. Immune-glutamatergic dysfunction as a central mechanism of the autism spectrum disorders. Curr Med Chem 2009; 16(2): 157-170. 206. Boksa P. Effects of prenatal infection on brain development and behavior: a review of findings from animal models. Brain Behav Immun 2010; 24(6): 881-897. 207. Bradstreet JJ, Smith S, Baral M, Rossignol DA. Biomarker-guided interventions of clinically relevant conditions associated with autism spectrum disorders and attention deficit hyperactivity disorder. Altern Med Rev 2010; 15(1): 15-32. 20 208. Bransfield RC, Wulfman JS, Harvey WT, Usman AI. The association between tick-borne infections, Lyme borreliosis and autism spectrum disorders. Med Hypotheses 2008; 70(5): 967-974. 209. Brudnak MA. Application of genomeceuticals to the molecular and immunological aspects of autism. Med Hypotheses 2001; 57(2): 186-191. 210. Burgess NK, Sweeten TL, McMahon WM, Fujinami RS. Hyperserotoninemia and altered immunity in autism. J Autism Dev Disord 2006; 36(5): 697-704. 211. Cannell JJ. Autism and vitamin D. Med Hypotheses 2008; 70(4): 750-759. 212. Careaga M, Van de Water J, Ashwood P. Immune dysfunction in autism: a pathway to treatment. Neurotherapeutics 2010; 7(3): 283-292. 213. Castellani ML, Conti CM, Kempuraj DJ, Salini V, Vecchiet J, Tete S et al. Autism and immunity: revisited study. Int J Immunopathol Pharmacol 2009; 22(1): 15-19. 214. Cavanna AE, Martino D, Orth M, Giovannoni G, Stern JS, Robertson MM et al. Neuropsychiatric-developmental model for the expression of tics, pervasive developmental disorder, and schizophreniform symptomatology associated with PANDAS. World J Biol Psychiatry 2009; 10(4 Pt 3): 1037-1038. 215. Cave SF. The history of vaccinations in the light of the autism epidemic. Altern Ther Health Med 2008; 14(6): 54-57. 216. Chez MG, Burton Q, Dowling T, Chang M, Khanna P, Kramer C. Memantine as adjunctive therapy in children diagnosed with autistic spectrum disorders: an observation of initial clinical response and maintenance tolerability. J Child Neurol 2007; 22(5): 574579. 217. Chez MG, Chin K, Hung PC. Immunizations, immunology, and autism. Semin Pediatr Neurol 2004; 11(3): 214-217. 218. Chez MG, Guido-Estrada N. Immune therapy in autism: historical experience and future directions with immunomodulatory therapy. Neurotherapeutics 2010; 7(3): 293-301. 219. Cohly HH, Panja A. Immunological findings in autism. Int Rev Neurobiol 2005; 71: 317341. 220. Cooper EL. Neuroimmunology of autism: a multifaceted hypothesis. Int J Immunopathol Pharmacol 2003; 16(3): 289-292. 221. Currenti SA. Understanding and determining the etiology of autism. Cell Mol Neurobiol 2010; 30(2): 161-171. 21 222. Dietert RR, Dietert JM. Potential for early-life immune insult including developmental immunotoxicity in autism and autism spectrum disorders: focus on critical windows of immune vulnerability. J Toxicol Environ Health B Crit Rev 2008; 11(8): 660-680. 223. Dochniak MJ. Autism spectrum disorders - Exogenous protein insult. Med Hypotheses 2007; 69(3): 545-549. 224. Francesetti G, Gecele M, Meluzzi A. [Psychoimmunology. II. The neuroendocrine system and the immune system in autism and schizophrenia]. Minerva Psichiatr 1991; 32(2): 75-82. 225. Geier DA, Kern JK, Geier MR. The biological basis of autism spectrum disorders: Understanding causation and treatment by clinical geneticists. Acta Neurobiol Exp (Wars) 2010; 70(2): 209-226. 226. Geier MR, Geier DA. The potential importance of steroids in the treatment of autistic spectrum disorders and other disorders involving mercury toxicity. Med Hypotheses 2005; 64(5): 946-954. 227. Goines P, Van de Water J. The immune system's role in the biology of autism. Curr Opin Neurol 2010; 23(2): 111-117. 228. Good P. Low-dose naltrexone for multiple sclerosis and autism: does its benefit reveal a common cause? Med Hypotheses 2006; 67(3): 671-672. 229. Grant WB, Soles CM. Epidemiologic evidence supporting the role of maternal vitamin D deficiency as a risk factor for the development of infantile autism. Dermatoendocrinol 2009; 1(4): 223-228. 230. Harrington JW, Rosen L, Garnecho A, Patrick PA. Parental perceptions and use of complementary and alternative medicine practices for children with autistic spectrum disorders in private practice. J Dev Behav Pediatr 2006; 27(2 Suppl): S156-161. 231. Hill JM. Vasoactive intestinal peptide in neurodevelopmental disorders: therapeutic potential. Curr Pharm Des 2007; 13(11): 1079-1089. 232. Ichim TE, Solano F, Glenn E, Morales F, Smith L, Zabrecky G et al. Stem cell therapy for autism. J Transl Med 2007; 5: 30. 233. Kidd PM. Autism, an extreme challenge to integrative medicine. Part 1: The knowledge base. Altern Med Rev 2002; 7(4): 292-316. 234. Kidd PM. Autism, an extreme challenge to integrative medicine. Part II: Medical management. Alternative Medicine Review 2002; 7(6): 472-499. 22 235. Kinney DK, Munir KM, Crowley DJ, Miller AM. Prenatal stress and risk for autism. Neurosci Biobehav Rev 2008. 236. Krause I, He XS, Gershwin ME, Shoenfeld Y. Brief report: immune factors in autism: a critical review. J Autism Dev Disord 2002; 32(4): 337-345. 237. Levy SE, Hyman SL. Novel treatments for autistic spectrum disorders. Ment Retard Dev Disabil Res Rev 2005; 11(2): 131-142. 238. Licinio J, Alvarado I, Wong ML. Autoimmunity in autism. Mol Psychiatry 2002; 7(4): 329. 239. Lintas C, Sacco R, Persico AM. Genome-wide expression studies in Autism spectrum disorder, Rett syndrome, and Down syndrome. Neurobiol Dis 2010. 240. Lipkin WI, Hornig M. Microbiology and immunology of autism spectrum disorders. Novartis Found Symp 2003; 251: 129-143; discussion 144-128, 281-197. 241. Malek-Ahmadi P. Cytokines and etiopathogenesis of pervasive developmental disorders. Med Hypotheses 2001; 56(3): 321-324. 242. Margutti P, Delunardo F, Ortona E. Autoantibodies associated with psychiatric disorders. Curr Neurovasc Res 2006; 3(2): 149-157. 243. Megson MN. Is autism a G-alpha protein defect reversible with natural vitamin A? Med Hypotheses 2000; 54(6): 979-983. 244. Melillo R, Leisman G. Autistic spectrum disorders as functional disconnection syndrome. Rev Neurosci 2009; 20(2): 111-131. 245. Moscavitch SD, Szyper-Kravitz M, Shoenfeld Y. Autoimmune pathology accounts for common manifestations in a wide range of neuro-psychiatric disorders: The olfactory and immune system interrelationship. Clin Immunol 2008. 246. Padhye U. Excess dietary iron is the root cause for increase in childhood autism and allergies. Med Hypotheses 2003; 61(2): 220-222. 247. Pardo-Govea T, Solis-Anez E. [Immunogenetic aspects of autism. Review]. Invest Clin 2009; 50(3): 393-406. 248. Parker-Athill EC, Tan J. Maternal Immune Activation and Autism Spectrum Disorder: Interleukin-6 Signaling as a Key Mechanistic Pathway. Neurosignals 2010. 249. Parr J. Autism. Clin Evid (Online) 2008; 2008. 23 250. Pessah IN, Seegal RF, Lein PJ, Lasalle J, Yee BK, Van De Water J et al. Immunologic and neurodevelopmental susceptibilities of autism. Neurotoxicology 2008; 29(3): 531544. 251. Posey DJ, McDougle CJ. The pathophysiology and treatment of autism. Curr Psychiatry Rep 2001; 3(2): 101-108. 252. Rada RE. Controversial issues in treating the dental patient with autism. J Am Dent Assoc 2010; 141(8): 947-953. 253. Rossignol DA. Hyperbaric oxygen therapy might improve certain pathophysiological findings in autism. Med Hypotheses 2007; 68(6): 1208-1227. 254. Rossignol DA. Novel and emerging treatments for autism spectrum disorders: a systematic review. Ann Clin Psychiatry 2009; 21(4): 213-236. 255. Rossignol DA, Rossignol LW. Hyperbaric oxygen therapy may improve symptoms in autistic children. Med Hypotheses 2006; 67(2): 216-228. 256. Singh VK. Phenotypic expression of autoimmune autistic disorder (AAD): a major subset of autism. Ann Clin Psychiatry 2009; 21(3): 148-161. 257. Sperner-Unterweger B, Winkler C, Fuchs D. Immune activation in autism. Pediatr Neurol 2006; 34(4): 333; author reply 333. 258. Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R et al. Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism. Cell 2004; 119(1): 19-31. 259. Steyaert JG, De la Marche W. What's new in autism? Eur J Pediatr 2008; 167(10): 10911101. 260. Theoharides TC. Autism spectrum disorders and mastocytosis. Int J Immunopathol Pharmacol 2009; 22(4): 859-865. 261. Todd RD. Pervasive developmental disorders and immunological tolerance. Psychiatr Dev 1986; 4(2): 147-165. 262. Torres AR. Is fever suppression involved in the etiology of autism and neurodevelopmental disorders? BMC Pediatr 2003; 3: 9. 263. Trottier G, Srivastava L, Walker CD. Etiology of infantile autism: a review of recent advances in genetic and neurobiological research. J Psychiatry Neurosci 1999; 24(2): 103-115. 24 264. van Gent T, Heijnen CJ, Treffers PD. Autism and the immune system. J Child Psychol Psychiatry 1997; 38(3): 337-349. 265. Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral D, Van de Water J. Autoantibodies in autism spectrum disorders (ASD). Ann N Y Acad Sci 2007; 1107: 79-91. 266. Senior K. Possible autoimmune enteropathy found in autistic children. Lancet 2002; 359(9318): 1674. 267. Korvatska E, Van de Water J, Anders TF, Gershwin ME. Genetic and immunologic considerations in autism. Neurobiol Dis 2002; 9(2): 107-125. 268. Watanabe Y, Hashimoto S, Kakita A, Takahashi H, Ko J, Mizuno M et al. Neonatal impact of leukemia inhibitory factor on neurobehavioral development in rats. Neurosci Res 2004; 48(3): 345-353. 269. Fatemi SH, Reutiman TJ, Folsom TD, Huang H, Oishi K, Mori S et al. Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders. Schizophr Res 2008; 99(1-3): 56-70. 270. Fatemi SH, Pearce DA, Brooks AI, Sidwell RW. Prenatal viral infection in mouse causes differential expression of genes in brains of mouse progeny: a potential animal model for schizophrenia and autism. Synapse 2005; 57(2): 91-99. 271. Baharnoori M, Bhardwaj SK, Srivastava LK. Neonatal Behavioral Changes in Rats With Gestational Exposure to Lipopolysaccharide: A Prenatal Infection Model for Developmental Neuropsychiatric Disorders. Schizophr Bull 2010. 272. Bhanja S, Mohanakumar KP. Early-life treatment of antiserotonin antibodies alters sensitivity to serotonin receptors, nociceptive stimulus and serotonin metabolism in adult rats. Int J Dev Neurosci 2010; 28(4): 317-324. 273. Ehninger D, Sano Y, de Vries PJ, Dies K, Franz D, Geschwind DH et al. Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice. Mol Psychiatry 2010. 274. Girard S, Tremblay L, Lepage M, Sebire G. IL-1 receptor antagonist protects against placental and neurodevelopmental defects induced by maternal inflammation. J Immunol 2010; 184(7): 3997-4005. 275. Godzien J, Ciborowski M, Angulo S, Ruperez FJ, Martinez MP, Senorans FJ et al. Metabolomic Approach with Lc-Qtof to Study the Effect of a Nutraceutical Treatment on Urine of Diabetic Rats. J Proteome Res 2010. 25 276. Hornig M, Briese T, Lipkin WI. Bornavirus tropism and targeted pathogenesis: virus-host interactions in a neurodevelopmental model. Adv Virus Res 2001; 56: 557-582. 277. Hornig M, Chian D, Lipkin WI. Neurotoxic effects of postnatal thimerosal are mouse strain dependent. Mol Psychiatry 2004; 9(9): 833-845. 278. Hornig M, Lipkin WI. Infectious and immune factors in the pathogenesis of neurodevelopmental disorders: epidemiology, hypotheses, and animal models. Ment Retard Dev Disabil Res Rev 2001; 7(3): 200-210. 279. Hornig M, Solbrig M, Horscroft N, Weissenbock H, Lipkin WI. Borna disease virus infection of adult and neonatal rats: models for neuropsychiatric disease. Curr Top Microbiol Immunol 2001; 253: 157-177. 280. Lancaster K, Dietz DM, Moran TH, Pletnikov MV. Abnormal social behaviors in young and adult rats neonatally infected with Borna disease virus. Behav Brain Res 2007; 176(1): 141-148. 281. Lee RH, Mills EA, Schwartz N, Bell MR, Deeg KE, Ruthazer ES et al. Neurodevelopmental effects of chronic exposure to elevated levels of pro-inflammatory cytokines in a developing visual system. Neural Dev 2010; 5: 2. 282. Li Q, Cheung C, Wei R, Hui ES, Feldon J, Meyer U et al. Prenatal immune challenge is an environmental risk factor for brain and behavior change relevant to schizophrenia: evidence from MRI in a mouse model. PLoS One 2009; 4(7): e6354. 283. MacFabe DF, Cain DP, Rodriguez-Capote K, Franklin AE, Hoffman JE, Boon F et al. Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behav Brain Res 2007; 176(1): 149-169. 284. Macfabe DF, Cain NE, Boon F, Ossenkopp KP, Cain DP. Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder. Behav Brain Res 2010. 285. Martin LA, Ashwood P, Braunschweig D, Cabanlit M, Van de Water J, Amaral DG. Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain Behav Immun 2008. 286. McAlonan GM, Li Q, Cheung C. The Timing and Specificity of Prenatal Immune Risk Factors for Autism Modeled in the Mouse and Relevance to Schizophrenia. Neurosignals 2010. 26 287. Meyer U, Nyffeler M, Engler A, Urwyler A, Schedlowski M, Knuesel I et al. The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J Neurosci 2006; 26(18): 4752-4762. 288. Meyer U, Nyffeler M, Schwendener S, Knuesel I, Yee BK, Feldon J. Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge. Neuropsychopharmacology 2008; 33(2): 441-456. 289. Meyer U, Nyffeler M, Yee BK, Knuesel I, Feldon J. Adult brain and behavioral pathological markers of prenatal immune challenge during early/middle and late fetal development in mice. Brain Behav Immun 2008; 22(4): 469-486. 290. Ni L, Acevedo G, Muralidharan B, Padala N, To J, Jonakait GM. Toll-like receptor ligands and CD154 stimulate microglia to produce a factor(s) that promotes excess cholinergic differentiation in the developing rat basal forebrain: implications for neurodevelopmental disorders. Pediatr Res 2007; 61(1): 15-20. 291. Parker-Athill E, Luo D, Bailey A, Giunta B, Tian J, Shytle RD et al. Flavonoids, a prenatal prophylaxis via targeting JAK2/STAT3 signaling to oppose IL-6/MIA associated autism. J Neuroimmunol 2009; 217(1-2): 20-27. 292. Patterson PH. Immune involvement in schizophrenia and autism: etiology, pathology and animal models. Behav Brain Res 2009; 204(2): 313-321. 293. Schneider T, Roman A, Basta-Kaim A, Kubera M, Budziszewska B, Schneider K et al. Gender-specific behavioral and immunological alterations in an animal model of autism induced by prenatal exposure to valproic acid. Psychoneuroendocrinology 2008; 33(6): 728-740. 294. Shi L, Fatemi SH, Sidwell RW, Patterson PH. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci 2003; 23(1): 297-302. 295. Shi L, Smith SE, Malkova N, Tse D, Su Y, Patterson PH. Activation of the maternal immune system alters cerebellar development in the offspring. Brain Behav Immun 2008. 296. Shultz SR, MacFabe DF, Ossenkopp KP, Scratch S, Whelan J, Taylor R et al. Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic endproduct, impairs social behavior in the rat: implications for an animal model of autism. Neuropharmacology 2008; 54(6): 901-911. 297. Shultz SR, Macfabe DF, Martin S, Jackson J, Taylor R, Boon F et al. Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism. Behav Brain Res 2009; 200(1): 33-41. 27 298. Singer HS, Morris C, Gause C, Pollard M, Zimmerman AW, Pletnikov M. Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model. J Neuroimmunol 2009. 299. Smith SE, Li J, Garbett K, Mirnics K, Patterson PH. Maternal immune activation alters fetal brain development through interleukin-6. J Neurosci 2007; 27(40): 10695-10702. 300. Welch MG, Welch-Horan TB, Anwar M, Anwar N, Ludwig RJ, Ruggiero DA. Brain effects of chronic IBD in areas abnormal in autism and treatment by single neuropeptides secretin and oxytocin. J Mol Neurosci 2005; 25(3): 259-274. 301. Zerrate MC, Pletnikov M, Connors SL, Vargas DL, Seidler FJ, Zimmerman AW et al. Neuroinflammation and behavioral abnormalities after neonatal terbutaline treatment in rats: implications for autism. J Pharmacol Exp Ther 2007; 322(1): 16-22. 302. Acampa M, Guideri F, Hayek J, Blardi P, De Lalla A, Zappella M et al. Sympathetic overactivity and plasma leptin levels in Rett syndrome. Neurosci Lett 2008; 432(1): 6972. 303. Alvarez-Saavedra M, Saez MA, Kang D, Zoghbi HY, Young JI. Cell-specific expression of wild-type MeCP2 in mouse models of Rett syndrome yields insight about pathogenesis. Hum Mol Genet 2007; 16(19): 2315-2325. 304. Armstrong DD, Deguchi K, Antallfy B. Survey of MeCP2 in the Rett syndrome and the non-Rett syndrome brain. J Child Neurol 2003; 18(10): 683-687. 305. Balmer D, Arredondo J, Samaco RC, LaSalle JM. MECP2 mutations in Rett syndrome adversely affect lymphocyte growth, but do not affect imprinted gene expression in blood or brain. Hum Genet 2002; 110(6): 545-552. 306. Cornford ME, Philippart M, Jacobs B, Scheibel AB, Vinters HV. Neuropathology of Rett syndrome: case report with neuronal and mitochondrial abnormalities in the brain. J Child Neurol 1994; 9(4): 424-431. 307. Deguchi K, Antalffy BA, Twohill LJ, Chakraborty S, Glaze DG, Armstrong DD. Substance P immunoreactivity in Rett syndrome. Pediatr Neurol 2000; 22(4): 259-266. 308. Deguchi K, Reyes C, Chakraborty S, Antalffy B, Glaze D, Armstrong D. Substance P immunoreactivity in the enteric nervous system in Rett syndrome. Brain Dev 2001; 23 Suppl 1: S127-132. 309. Delgado IJ, Kim DS, Thatcher KN, LaSalle JM, Van den Veyver IB. Expression profiling of clonal lymphocyte cell cultures from Rett syndrome patients. BMC Med Genet 2006; 7: 61. 28 310. Fiumara A, Sciotto A, Barone R, D'Asero G, Munda S, Parano E et al. Peripheral lymphocyte subsets and other immune aspects in Rett syndrome. Pediatr Neurol 1999; 21(3): 619-621. 311. Gratchev VV, Bashina VM, Klushnik TP, Ulas VU, Gorbachevskaya NL, Vorsanova SG. Clinical, neurophysiological and immunological correlations in classical Rett syndrome. Brain Dev 2001; 23 Suppl 1: S108-112. 312. Guideri F, Acampa M, Calamandrei G, Aloe L, Zappella M, Hayek Y. Nerve growth factor plasma levels and ventricular repolarization in Rett syndrome. Pediatr Cardiol 2004; 25(4): 394-396. 313. Kerr AM. Early clinical signs in the Rett disorder. Neuropediatrics 1995; 26(2): 67-71. 314. Kliushnik TP, Grachev VV, Turkova IL, Ermakova SA, Liderman RR. [Autoantibodies to nerve growth factor and astroglial protein S-100 in Rett's syndrome]. Zh Nevrol Psikhiatr Im S S Korsakova 2001; 101(1): 45-48. 315. Klushnik TP, Gratchev VV, Belichenko PV. Brain-directed autoantibodies levels in the serum of Rett syndrome patients. Brain Dev 2001; 23 Suppl 1: S113-117. 316. Lipani JD, Bhattacharjee MB, Corey DM, Lee DA. Reduced nerve growth factor in Rett syndrome postmortem brain tissue. J Neuropathol Exp Neurol 2000; 59(10): 889-895. 317. Messahel S, Pheasant AE, Pall H, Kerr AM. Abnormalities in urinary pterin levels in Rett syndrome. Eur J Paediatr Neurol 2000; 4(5): 211-217. 318. Ramaekers VT, Sequeira JM, Artuch R, Blau N, Temudo T, Ormazabal A et al. Folate receptor autoantibodies and spinal fluid 5-methyltetrahydrofolate deficiency in Rett syndrome. Neuropediatrics 2007; 38(4): 179-183. 319. Reichelt KL, Skjeldal O. IgA antibodies in Rett syndrome. Autism 2006; 10(2): 189-197. 320. Riikonen R, Meurman O. Long-term persistence of intrathecal viral antibody responses in postinfectious diseases of the central nervous system and in Rett syndrome. Neuropediatrics 1989; 20(4): 215-219. 321. Stefanatos GA, Grover W, Geller E. Case study: corticosteroid treatment of language regression in pervasive developmental disorder. J Am Acad Child Adolesc Psychiatry 1995; 34(8): 1107-1111. 322. Adams JB, Baral M, Geis E, Mitchell J, Ingram J, Hensley A et al. Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: part A--medical results. BMC Clin Pharmacol 2009; 9: 16. 29 323. Boris M, Goldblatt A, Edelson SM. Improvement in children with autism treated with intravenous gamma globulin. J Nutritional Environmental Medicine 2005; 15(4): 169176. 324. Akhondzadeh S, Fallah J, Mohammadi MR, Imani R, Mohammadi M, Salehi B et al. Double-blind placebo controlled trial of pentoxifylline added to risperidone: Effects on aberrant behavior in children with autism. Prog Neuropsychopharmacol Biol Psychiatry 2009. 325. Boris M, Kaiser CC, Goldblatt A, Elice MW, Edelson SM, Adams JB et al. Effect of pioglitazone treatment on behavioral symptoms in autistic children. J Neuroinflammation 2007; 4: 3. 326. Bouvard MP, Leboyer M, Launay JM, Recasens C, Plumet MH, Waller-Perotte D et al. Low-dose naltrexone effects on plasma chemistries and clinical symptoms in autism: a double-blind, placebo-controlled study. Psychiatry Res 1995; 58(3): 191-201. 327. Bradstreet JJ, Smith S, Granpeesheh D, El-Dahr JM, Rossignol D. Spironolactone might be a desirable immunologic and hormonal intervention in autism spectrum disorders. Med Hypotheses 2007; 68(5): 979-987. 328. Emanuele E, Lossano C, Politi P, Barale F. Pioglitazone as a therapeutic agent in autistic spectrum disorder. Med Hypotheses 2007; 69(3): 699. 329. Fudenberg HH. Dialysable lymphocyte extract (DLyE) in infantile onset autism: a pilot study. Biotherapy 1996; 9(1-3): 143-147. 330. Gupta S. Treatment of children with autism with intravenous immunoglobulin. J Child Neurol 1999; 14(3): 203-205. 331. Gupta S. Immunological treatments for autism. J Autism Dev Disord 2000; 30(5): 475479. 332. Gupta S, Aggarwal S, Heads C. Dysregulated immune system in children with autism: beneficial effects of intravenous immune globulin on autistic characteristics. J Autism Dev Disord 1996; 26(4): 439-452. 333. Gupta S, Rimland B, Shilling PD. Pentoxifylline: brief review and rationale for its possible use in the treatment of autism. J Child Neurol 1996; 11(6): 501-504. 334. Niederhofer H, Staffen W, Mair A. Immunoglobulins as an alternative strategy of psychopharmacological treatment of children with autistic disorder. Neuropsychopharmacology 2003; 28(5): 1014-1015. 30 335. Plioplys AV. Intravenous immunoglobulin treatment of children with autism. J Child Neurol 1998; 13(2): 79-82. 336. Plioplys AV. Intravenous immunoglobulin treatment in autism. J Autism Dev Disord 2000; 30(1): 73-74. 337. Rossignol DA, Rossignol LW, James SJ, Melnyk S, Mumper E. The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study. BMC Pediatr 2007; 7(1): 36. 338. Scifo R, Cioni M, Nicolosi A, Batticane N, Tirolo C, Testa N et al. Opioid-immune interactions in autism: behavioural and immunological assessment during a double-blind treatment with naltrexone. Ann Ist Super Sanita 1996; 32(3): 351-359. 339. Shenoy S, Arnold S, Chatila T. Response to steroid therapy in autism secondary to autoimmune lymphoproliferative syndrome. J Pediatr 2000; 136(5): 682-687. 340. Singh VK, Fudenberg HH, Emerson D, Coleman M. Immunodiagnosis and immunotherapy in autistic children. Ann N Y Acad Sci 1988; 540: 602-604. 341. DelGiudice-Asch G, Simon L, Schmeidler J, Cunningham-Rundles C, Hollander E. Brief report: a pilot open clinical trial of intravenous immunoglobulin in childhood autism. J Autism Dev Disord 1999; 29(2): 157-160. 342. Nagarajan RP, Hogart AR, Gwye Y, Martin MR, LaSalle JM. Reduced MeCP2 expression is frequent in autism frontal cortex and correlates with aberrant MECP2 promoter methylation. Epigenetics 2006; 1(4): e1-11. 343. Sheikh AM, Malik M, Wen G, Chauhan A, Chauhan V, Gong CX et al. BDNF-Akt-Bcl2 antiapoptotic signaling pathway is compromised in the brain of autistic subjects. J Neurosci Res 2010; 88(12): 2641-2647. 344. Sheikh AM, Li X, Wen G, Tauqeer Z, Brown WT, Malik M. Cathepsin D and apoptosis related proteins are elevated in the brain of autistic subjects. Neuroscience 2010; 165(2): 363-370. 345. Sajdel-Sulkowska EM, Xu M, Koibuchi N. Increase in Cerebellar Neurotrophin-3 and Oxidative Stress Markers in Autism. Cerebellum 2009. 346. Sajdel-Sulkowska EM, Lipinski B, Windom H, Audhya T, McGinnis WR. Oxidative stress in autism: elevated cerebellar 3-nitrotyrosine levels. Am J Biochem Biotech 2008; 4(2): 73-84. 31 347. Ramaekers VT, Rothenberg SP, Sequeira JM, Opladen T, Blau N, Quadros EV et al. Autoantibodies to folate receptors in the cerebral folate deficiency syndrome. N Engl J Med 2005; 352(19): 1985-1991. 348. Plioplys AV, Greaves A, Kazemi K, Silverman E. Immunoglobin reactivity in autism and Rett's syndrome. Developmental Brain Dysfunction 1994; 7(1): 12-16. 349. Nordin V, Lekman A, Johansson M, Fredman P, Gillberg C. Gangliosides in cerebrospinal fluid in children with autism spectrum disorders. Dev Med Child Neurol 1998; 40(9): 587-594. 350. Lintas C, Altieri L, Lombardi F, Sacco R, Persico AM. Association of autism with polyomavirus infection in postmortem brains. J Neurovirol 2010; 16(2): 141-149. 351. Ghaziuddin M, Al-Khouri I, Ghaziuddin N. Autistic symptoms following herpes encephalitis. Eur Child Adolesc Psychiatry 2002; 11(3): 142-146. 352. Fatemi SH, Snow AV, Stary JM, Araghi-Niknam M, Reutiman TJ, Lee S et al. Reelin signaling is impaired in autism. Biol Psychiatry 2005; 57(7): 777-787. 353. Araghi-Niknam M, Fatemi SH. Levels of Bcl-2 and P53 are altered in superior frontal and cerebellar cortices of autistic subjects. Cell Mol Neurobiol 2003; 23(6): 945-952. 354. Boso M, Emanuele E, Minoretti P, Arra M, Politi P, Ucelli di Nemi S et al. Alterations of circulating endogenous secretory RAGE and S100A9 levels indicating dysfunction of the AGE-RAGE axis in autism. Neurosci Lett 2006; 410(3): 169-173. 355. Braunschweig D, Ashwood P, Krakowiak P, Hertz-Picciotto I, Hansen R, Croen LA et al. Autism: maternally derived antibodies specific for fetal brain proteins. Neurotoxicology 2008; 29(2): 226-231. 356. Cabanlit M, Wills S, Goines P, Ashwood P, Van de Water J. Brain-specific autoantibodies in the plasma of subjects with autistic spectrum disorder. Ann N Y Acad Sci 2007; 1107: 92-103. 357. Chez MG, Dowling T, Patel PB, Khanna P, Kominsky M. Elevation of tumor necrosis factor-alpha in cerebrospinal fluid of autistic children. Pediatr Neurol 2007; 36(6): 361365. 358. Connolly AM, Chez MG, Pestronk A, Arnold ST, Mehta S, Deuel RK. Serum autoantibodies to brain in Landau-Kleffner variant, autism, and other neurologic disorders. J Pediatr 1999; 134(5): 607-613. 359. Connolly AM, Chez M, Streif EM, Keeling RM, Golumbek PT, Kwon JM et al. Brainderived neurotrophic factor and autoantibodies to neural antigens in sera of children with 32 autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsy. Biol Psychiatry 2006; 59(4): 354-363. 360. Correia C, Coutinho AM, Almeida J, Lontro R, Lobo C, Miguel TS et al. Association of the alpha4 integrin subunit gene (ITGA4) with autism. Am J Med Genet B Neuropsychiatr Genet 2009; 150B(8): 1147-1151. 361. Croen LA, Braunschweig D, Haapanen L, Yoshida CK, Fireman B, Grether JK et al. Maternal mid-pregnancy autoantibodies to fetal brain protein: the early markers for autism study. Biol Psychiatry 2008; 64(7): 583-588. 362. Fatemi SH, Folsom TD, Reutiman TJ, Lee S. Expression of astrocytic markers aquaporin 4 and connexin 43 is altered in brains of subjects with autism. Synapse 2008; 62(7): 501507. 363. Fatemi SH, Halt AR, Stary JM, Realmuto GM, Jalali-Mousavi M. Reduction in antiapoptotic protein Bcl-2 in autistic cerebellum. Neuroreport 2001; 12(5): 929-933. 364. Fatemi SH, Stary JM, Halt AR, Realmuto GR. Dysregulation of Reelin and Bcl-2 proteins in autistic cerebellum. J Autism Dev Disord 2001; 31(6): 529-535. 365. Garbett K, Ebert PJ, Mitchell A, Lintas C, Manzi B, Mirnics K et al. Immune transcriptome alterations in the temporal cortex of subjects with autism. Neurobiol Dis 2008; 30(3): 303-311. 366. Goines P, Haapanen L, Boyce R, Duncanson P, Braunschweig D, Delwiche L et al. Autoantibodies To Cerebellum In Children With Autism Associate With Behavior. Brain Behav Immun 2010. 367. Gonzalez-Gronow M, Cuchacovich M, Francos R, Cuchacovich S, Del Pilar Fernandez M, Blanco A et al. Antibodies against the voltage-dependent anion channel (VDAC) and its protective ligand hexokinase-I in children with autism. J Neuroimmunol 2010. 368. Kozlovskaia GV, Kliushnik TP, Goriunova AV, Turkova IL, Kalinina MA, Sergienko NS. [Nerve growth factor auto-antibodies in children with various forms of mental dysontogenesis and in schizophrenia high risk group]. Zh Nevrol Psikhiatr Im S S Korsakova 2000; 100(3): 50-52. 369. Laurence JA, Fatemi SH. Glial fibrillary acidic protein is elevated in superior frontal, parietal and cerebellar cortices of autistic subjects. Cerebellum 2005; 4(3): 206-210. 370. Li X, Chauhan A, Sheikh AM, Patil S, Chauhan V, Li XM et al. Elevated immune response in the brain of autistic patients. J Neuroimmunol 2009; 207(1-2): 111-116. 33 371. Mora M, Quintero L, Cardenas R, Suarez-Roca H, Zavala M, Montiel N. [Association between HSV-2 infection and serum anti-rat brain antibodies in patients with autism]. Invest Clin 2009; 50(3): 315-326. 372. Morgan JT, Chana G, Pardo CA, Achim C, Semendeferi K, Buckwalter J et al. Microglial Activation and Increased Microglial Density Observed in the Dorsolateral Prefrontal Cortex in Autism. Biol Psychiatry 2010; 68(4): 368-376. 373. Mostafa GA, El-Sayed ZA, El-Aziz MM, El-Sayed MF. Serum anti-myelin-associated glycoprotein antibodies in Egyptian autistic children. J Child Neurol 2008; 23(12): 14131418. 374. Ramaekers VT, Blau N, Sequeira JM, Nassogne MC, Quadros EV. Folate receptor autoimmunity and cerebral folate deficiency in low-functioning autism with neurological deficits. Neuropediatrics 2007; 38(6): 276-281. 375. Silva SC, Correia C, Fesel C, Barreto M, Coutinho AM, Marques C et al. Autoantibody repertoires to brain tissue in autism nuclear families. J Neuroimmunol 2004; 152(1-2): 176-182. 376. Singer HS, Morris CM, Gause CD, Gillin PK, Crawford S, Zimmerman AW. Antibodies against fetal brain in sera of mothers with autistic children. J Neuroimmunol 2008; 194(12): 165-172. 377. Singer HS, Morris CM, Williams PN, Yoon DY, Hong JJ, Zimmerman AW. Antibrain antibodies in children with autism and their unaffected siblings. J Neuroimmunol 2006; 178(1-2): 149-155. 378. Singh VK, Lin SX, Newell E, Nelson C. Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism. J Biomed Sci 2002; 9(4): 359-364. 379. Singh VK, Lin SX, Yang VC. Serological association of measles virus and human herpesvirus-6 with brain autoantibodies in autism. Clin Immunol Immunopathol 1998; 89(1): 105-108. 380. Singh VK, Rivas WH. Prevalence of serum antibodies to caudate nucleus in autistic children. Neurosci Lett 2004; 355(1-2): 53-56. 381. Singh VK, Warren R, Averett R, Ghaziuddin M. Circulating autoantibodies to neuronal and glial filament proteins in autism. Pediatr Neurol 1997; 17(1): 88-90. 382. Singh VK, Warren RP, Odell JD, Warren WL, Cole P. Antibodies to myelin basic protein in children with autistic behavior. Brain Behav Immun 1993; 7(1): 97-103. 34 383. Sokol DK, Chen LS, Wagenknecht DR, McIntyre JA. Anti-phospholipid antibodies in cerebrospinal fluid but not serum from a boy with psychosis. Pediatr Neurol 2008; 39(4): 293-294. 384. Todd RD, Hickok JM, Anderson GM, Cohen DJ. Antibrain antibodies in infantile autism. Biol Psychiatry 1988; 23(6): 644-647. 385. Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol 2005; 57(1): 67-81. 386. Vojdani A, Campbell AW, Anyanwu E, Kashanian A, Bock K, Vojdani E. Antibodies to neuron-specific antigens in children with autism: possible cross-reaction with encephalitogenic proteins from milk, Chlamydia pneumoniae and Streptococcus group A. J Neuroimmunol 2002; 129(1-2): 168-177. 387. Vojdani A, O'Bryan T, Green JA, McCandless J, Woeller KN, Vojdani E et al. Immune response to dietary proteins, gliadin and cerebellar peptides in children with autism. Nutr Neurosci 2004; 7(3): 151-161. 388. Weizman A, Weizman R, Szekely GA, Wijsenbeek H, Livni E. Abnormal immune response to brain tissue antigen in the syndrome of autism. Am J Psychiatry 1982; 139(11): 1462-1465. 389. Wills S, Cabanlit M, Bennett J, Ashwood P, Amaral DG, Van de Water J. Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders. Brain Behav Immun 2008. 390. Zimmerman AW, Connors SL, Matteson KJ, Lee LC, Singer HS, Castaneda JA et al. Maternal antibrain antibodies in autism. Brain Behav Immun 2007; 21(3): 351-357. 391. Zimmerman AW, Jyonouchi H, Comi AM, Connors SL, Milstien S, Varsou A et al. Cerebrospinal fluid and serum markers of inflammation in autism. Pediatr Neurol 2005; 33(3): 195-201. 392. Brun CC, Nicolson R, Lepore N, Chou YY, Vidal CN, DeVito TJ et al. Mapping brain abnormalities in boys with autism. Hum Brain Mapp 2009; 30(12): 3887-3900. 393. Dalton P, Deacon R, Blamire A, Pike M, McKinlay I, Stein J et al. Maternal neuronal antibodies associated with autism and a language disorder. Ann Neurol 2003; 53(4): 533537. 394. Ramaekers VT. The mystery of autism. Les voies mystarieuses de l'autisme 2008; 63(SPEC. ISS.): 26-34. 35 395. Fatemi SH. Multiple pathways in prevention of immune-mediated brain disorders: Implications for the prevention of autism. J Neuroimmunol 2009. 396. Casanova MF. The minicolumnopathy of autism: A link between migraine and gastrointestinal symptoms. Med Hypotheses 2008; 70(1): 73-80. 397. Cortesi M, Alfei E, Barale F, Fusar-Poli P. Linking autism, regression and LandauKleffner syndrome: integrative role of nerve growth factor. Med Hypotheses 2007; 68(5): 1178-1179. 398. Dantzer R, Kelley KW. Autistic children: a neuroimmune perspective. Brain Behav Immun 2008; 22(6): 804-805. 399. Derecki NC, Privman E, Kipnis J. Rett syndrome and other autism spectrum disorders-brain diseases of immune malfunction? Mol Psychiatry 2010; 15(4): 355-363. 400. Enstrom AM, Van de Water JA, Ashwood P. Autoimmunity in autism. Curr Opin Investig Drugs 2009; 10(5): 463-473. 401. Herbert MR. Large brains in autism: the challenge of pervasive abnormality. Neuroscientist 2005; 11(5): 417-440. 402. Herbert MR. Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders. Curr Opin Neurol 2010. 403. Pardo CA, Vargas DL, Zimmerman AW. Immunity, neuroglia and neuroinflammation in autism. Int Rev Psychiatry 2005; 17(6): 485-495. 404. Rout UK, Dhossche DM. A pathogenetic model of autism involving Purkinje cell loss through anti-GAD antibodies. Med Hypotheses 2008; 71(2): 218-221. 405. Theoharides TC, Kempuraj D, Redwood L. Autism: an emerging 'neuroimmune disorder' in search of therapy. Expert Opin Pharmacother 2009; 10(13): 2127-2143. 406. Westall FC, Root-Bernstein RS. Suggested connection between autism, serotonin, and myelin basic protein. Am J Psychiatry 1983; 140(9): 1260-1261. 407. Torrente F, Anthony A, Heuschkel RB, Thomson MA, Ashwood P, Murch SH. Focalenhanced gastritis in regressive autism with features distinct from Crohn's and Helicobacter pylori gastritis. Am J Gastroenterol 2004; 99(4): 598-605. 408. Russo AJ, Neville L, Wroge C. Low serum alpha-1 antitrypsin (AAT) in family members of individuals with autism correlates with PiMZ genotype. Biomark Insights 2009; 4: 4556. 36 409. Horvath K, Perman JA. Autistic disorder and gastrointestinal disease. Curr Opin Pediatr 2002; 14(5): 583-587. 410. Genuis SJ, Bouchard TP. Celiac Disease Presenting as Autism. J Child Neurol 2009. 411. Finegold SM, Molitoris D, Song Y, Liu C, Vaisanen ML, Bolte E et al. Gastrointestinal microflora studies in late-onset autism. Clin Infect Dis 2002; 35(Suppl 1): S6-S16. 412. Finegold SM, Dowd SE, Gontcharova V, Liu C, Henley KE, Wolcott RD et al. Pyrosequencing study of fecal microflora of autistic and control children. Anaerobe 2010; 16(4): 444-453. 413. Cade R, Privette M, Fregly M, Rowland N, Sun Z, Zele V et al. Autism and schizophrenia: intestinal disorders. Nutritional Neuroscience 2000; 3: 57-72. 414. Ashwood P, Anthony A, Pellicer AA, Torrente F, Walker-Smith JA, Wakefield AJ. Intestinal lymphocyte populations in children with regressive autism: evidence for extensive mucosal immunopathology. J Clin Immunol 2003; 23(6): 504-517. 415. Ashwood P, Anthony A, Torrente F, Wakefield AJ. Spontaneous mucosal lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms: mucosal immune activation and reduced counter regulatory interleukin-10. J Clin Immunol 2004; 24(6): 664-673. 416. Ashwood P, Wakefield AJ. Immune activation of peripheral blood and mucosal CD3+ lymphocyte cytokine profiles in children with autism and gastrointestinal symptoms. J Neuroimmunol 2006; 173(1-2): 126-134. 417. Balzola F, Barbon V, Repici A, Rizzetto M, Clauser D, Gandione M et al. Panenteric IBD-like disease in a patient with regressive autism shown for the first time by the wireless capsule enteroscopy: another piece in the jigsaw of this gut-brain syndrome? Am J Gastroenterol 2005; 100(4): 979-981. 418. Chen B, Girgis S, El-Matary W. Childhood Autism and Eosinophilic Colitis. Digestion 2009; 81(2): 127-129. 419. Horvath K, Perman JA. Autism and gastrointestinal symptoms. Curr Gastroenterol Rep 2002; 4(3): 251-258. 420. Jarocka-Cyrta E, Wasilewska J, Kaczmarski MG. Brief Report: Eosinophilic Esophagitis as a Cause of Feeding Problems in Autistic Boy. The First Reported Case. J Autism Dev Disord 2010. 421. Jyonouchi H, Geng L, Ruby A, Reddy C, Zimmerman-Bier B. Evaluation of an association between gastrointestinal symptoms and cytokine production against common 37 dietary proteins in children with autism spectrum disorders. J Pediatr 2005; 146(5): 605610. 422. Jyonouchi H, Geng L, Ruby A, Zimmerman-Bier B. Dysregulated innate immune responses in young children with autism spectrum disorders: their relationship to gastrointestinal symptoms and dietary intervention. Neuropsychobiology 2005; 51(2): 7785. 423. Torrente F, Ashwood P, Day R, Machado N, Furlano RI, Anthony A et al. Small intestinal enteropathy with epithelial IgG and complement deposition in children with regressive autism. Mol Psychiatry 2002; 7(4): 375-382, 334. 424. Uhlmann V, Martin CM, Sheils O, Pilkington L, Silva I, Killalea A et al. Potential viral pathogenic mechanism for new variant inflammatory bowel disease. Mol Pathol 2002; 55(2): 84-90. 425. Valicenti-McDermott M, McVicar K, Rapin I, Wershil BK, Cohen H, Shinnar S. Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. J Dev Behav Pediatr 2006; 27(2 Suppl): S128-136. 426. Valicenti-McDermott MD, McVicar K, Cohen HJ, Wershil BK, Shinnar S. Gastrointestinal symptoms in children with an autism spectrum disorder and language regression. Pediatr Neurol 2008; 39(6): 392-398. 427. Wakefield AJ, Anthony A, Murch SH, Thomson M, Montgomery SM, Davies S et al. Enterocolitis in children with developmental disorders. Am J Gastroenterol 2000; 95(9): 2285-2295. 428. Wakefield AJ, Ashwood P, Limb K, Anthony A. The significance of ileo-colonic lymphoid nodular hyperplasia in children with autistic spectrum disorder. Eur J Gastroenterol Hepatol 2005; 17(8): 827-836. 429. Schneider CK, Melmed RD, Barstow LE, Enriquez FJ, Ranger-Moore J, Ostrem JA. Oral human immunoglobulin for children with autism and gastrointestinal dysfunction: a prospective, open-label study. J Autism Dev Disord 2006; 36(8): 1053-1064. 430. Furlano RI, Anthony A, Day R, Brown A, McGarvey L, Thomson MA et al. Colonic CD8 and gamma delta T-cell infiltration with epithelial damage in children with autism. J Pediatr 2001; 138(3): 366-372. 431. Jyonouchi H. Food allergy and autism spectrum disorders: is there a link? Curr Allergy Asthma Rep 2009; 9(3): 194-201. 38 432. Wakefield AJ, Puleston JM, Montgomery SM, Anthony A, O'Leary JJ, Murch SH. Review article: the concept of entero-colonic encephalopathy, autism and opioid receptor ligands. Aliment Pharmacol Ther 2002; 16(4): 663-674. 433. Wasilewska J, Jarocka-Cyrta E, Kaczmarski M. [Gastrointestinal abnormalities in children with autism]. Pol Merkur Lekarski 2009; 27(157): 40-43. 434. White JF. Intestinal pathophysiology in autism. Exp Biol Med (Maywood) 2003; 228(6): 639-649. 435. Jass JR. The intestinal lesion of autistic spectrum disorder. Eur J Gastroenterol Hepatol 2005; 17(8): 821-822. 436. Galiatsatos P, Gologan A, Lamoureux E. Autistic enterocolitis: fact or fiction? Can J Gastroenterol 2009; 23(2): 95-98. 437. Cubala-Kucharska M. The review of most frequently occurring medical disorders related to aetiology of autism and the methods of treatment. Acta Neurobiol Exp (Wars) 2010; 70(2): 141-146. 438. Wilson K, Mills E, Ross C, McGowan J, Jadad A. Association of autistic spectrum disorder and the measles, mumps, and rubella vaccine: a systematic review of current epidemiological evidence. Arch Pediatr Adolesc Med 2003; 157(7): 628-634. 439. Taylor B, Miller E, Farrington CP, Petropoulos MC, Favot-Mayaud I, Li J et al. Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. Lancet 1999; 353(9169): 2026-2029. 440. Taylor B. Vaccines and the changing epidemiology of autism. Child Care Health Dev 2006; 32(5): 511-519. 441. Smith MJ, Ellenberg SS, Bell LM, Rubin DM. Media coverage of the measles-mumpsrubella vaccine and autism controversy and its relationship to MMR immunization rates in the United States. Pediatrics 2008; 121(4): e836-843. 442. Smeeth L, Hall AJ, Fombonne E, Rodrigues LC, Huang X, Smith PG. A case-control study of autism and mumps-measles-rubella vaccination using the general practice research database: design and methodology. BMC Public Health 2001; 1: 2. 443. Smeeth L, Cook C, Fombonne E, Heavey L, Rodrigues LC, Smith PG et al. MMR vaccination and pervasive developmental disorders: a case-control study. Lancet 2004; 364(9438): 963-969. 444. Skegg DC. Autism and measles-mumps-rubella (MMR) vaccination: a challenge for pharmacoepidemiology. Pharmacotherapy 2003; 23(12): 1521-1523. 39 445. Sengupta N, Bedford H, Elliman D, Booy R. Does the MMR triple vaccine cause autism? Evidence-Based Healthcare and Public Health 2004; 8(5): 239-245. 446. Richler J, Luyster R, Risi S, Hsu WL, Dawson G, Bernier R et al. Is there a 'regressive phenotype' of Autism Spectrum Disorder associated with the measles-mumps-rubella vaccine? A CPEA Study. J Autism Dev Disord 2006; 36(3): 299-316. 447. Parker SK, Schwartz B, Todd J, Pickering LK. Thimerosal-containing vaccines and autistic spectrum disorder: a critical review of published original data. Pediatrics 2004; 114(3): 793-804. 448. Offit PA, Coffin SE. Communicating science to the public: MMR vaccine and autism. Vaccine 2003; 22(1): 1-6. 449. Nelson KB, Bauman ML. Thimerosal and autism? Pediatrics 2003; 111(3): 674-679. 450. Miller L, Reynolds J. Autism and vaccination-the current evidence. J Spec Pediatr Nurs 2009; 14(3): 166-172. 451. Madsen KM, Vestergaard M. MMR vaccination and autism : what is the evidence for a causal association? Drug Saf 2004; 27(12): 831-840. 452. Madsen KM, Hviid A, Vestergaard M, Schendel D, Wohlfahrt J, Thorsen P et al. A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med 2002; 347(19): 1477-1482. 453. Madsen KM, Hvid A, Vestergaard M, Frid PJ. The measles, mumps, and rubella vaccine was not associated with autism in children. Evidence-Based Medicine 2003; 8(3): 93. 454. Macdonald TT, Domizio P. Autistic enterocolitis: is it a histopathological entity? Histopathology 2007; 51(4): 552-553. 455. Klein KC, Diehl EB. Relationship between MMR vaccine and autism. Ann Pharmacother 2004; 38(7-8): 1297-1300. 456. Grimprel Ã. Measles and autism. Rougeole et autisme 2004; 11(8): 999-1001. 457. Geier DA, Geier MR. A comparative evaluation of the effects of MMR immunization and mercury doses from thimerosal-containing childhood vaccines on the population prevalence of autism. Med Sci Monit 2004; 10(3): PI33-39. 458. Fombonne E, Cook EH. MMR and autistic enterocolitis: consistent epidemiological failure to find an association. Mol Psychiatry 2003; 8(2): 133-134. 40 459. Doja A, Roberts W. Immunizations and autism: a review of the literature. Can J Neurol Sci 2006; 33(4): 341-346. 460. DeStefano F, Thompson WW. MMR vaccine and autism: an update of the scientific evidence. Expert Rev Vaccines 2004; 3(1): 19-22. 461. DeStefano F, Bhasin TK, Thompson WW, Yeargin-Allsopp M, Boyle C. Age at first measles-mumps-rubella vaccination in children with autism and school-matched control subjects: a population-based study in metropolitan atlanta. Pediatrics 2004; 113(2): 259266. 462. DeStefano F. Vaccines and autism: evidence does not support a causal association. Clin Pharmacol Ther 2007; 82(6): 756-759. 463. DeStefano F. Vaccines and autism. Pediatr Infect Dis J 2001; 20(9): 887-888. 464. Chen W, Landau S, Sham P, Fombonne E. No evidence for links between autism, MMR and measles virus. Psychol Med 2004; 34(3): 543-553. 465. Bortolussi R, Moore DL, Robinson JL, Rousseau-Harsany Ã, Samson LM, MacDonald NE et al. Autistic spectrum disorder: No causal relationship with vaccines. Canadian Journal of Infectious Diseases and Medical Microbiology 2007; 18(3): 177-179. 466. Baird G, Brown D, Simonoff E, Pickles A, Charman T. No evidence for MMR-ASD link. Practitioner 2008; 252(1704): 6. 467. Afzal MA, Ozoemena LC, O'Hare A, Kidger KA, Bentley ML, Minor PD. Absence of detectable measles virus genome sequence in blood of autistic children who have had their MMR vaccination during the routine childhood immunization schedule of UK. J Med Virol 2006; 78(5): 623-630. 468. Afzal MA, Minor PD. Vaccines, Crohn's disease and autism. Mol Psychiatry 2002; 7 Suppl 2: S49-50. 469. Afzal MA, Minor PD, Ghosh S, Jin L. Measles virus persistence in specimens of inflammatory bowel disease and autism cases. Dig Dis Sci 2001; 46(3): 658-660. 470. Afzal MA, Minor PD, Schild GC. Clinical safety issues of measles, mumps and rubella vaccines. Bull World Health Organ 2000; 78(2): 199-204. 471. Akobeng AK, Thomas AG. Inflammatory bowel disease, autism, and the measles, mumps, and rubella vaccine. J Pediatr Gastroenterol Nutr 1999; 28(3): 351-352. 41 472. Amin J, McIntyre PB, Heath TC. Measles vaccine, inflammatory bowel disease and pervasive developmental disorder: is there cause for concern? Commun Dis Intell 1998; 22(4): 58-59. 473. Amin J, Wong M. Measles-mumps-rubella immunisation, autism and inflammatory bowel disease: update. Commun Dis Intell 1999; 23(8): 222. 474. Arlett P, Bryan P, Evans S. A response to 'measles, mumps, rubella vaccine: through a glass, darkly' by Drs AJ Wakefield and SM Montgomery and published reviewers' comments. Adverse Drug React Toxicol Rev 2001; 20(1): 37-45. 475. Baird G, Pickles A, Simonoff E, Charman T, Sullivan P, Chandler S et al. Measles vaccination and antibody response in autism spectrum disorders. Arch Dis Child 2008. 476. Barr R. Autism, bowel inflammation, and measles. Lancet 2002; 359(9323): 2112. 477. Beale AJ. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9106): 906; author reply 908-909. 478. Bedford H, Booy R, Dunn D, DiGuiseppi C, Gibb D, Gilbert R et al. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9106): 907; author reply 908-909. 479. Bhatt R. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9112): 1357. 480. Black D, Prempeh H, Baxter T. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9106): 905-906; author reply 908-909. 481. Borchers AT, Keen CL, Shoenfeld Y, Silva J, Jr., Gershwin ME. Vaccines, viruses, and voodoo. J Investig Allergol Clin Immunol 2002; 12(3): 155-168. 482. Bryan J. MMR vaccine. Immune to argument? Health Serv J 1999; 109(5678): suppl 4-5. 483. de Los Reyes EC. Autism and immunizations: separating fact from fiction. Arch Neurol 2010; 67(4): 490-492. 484. DeStefano F. MMR vaccine and autism: a review of the evidence for a causal association. Mol Psychiatry 2002; 7 Suppl 2: S51-52. 485. DeStefano F, Chen RT. Negative association between MMR and autism. Lancet 1999; 353(9169): 1987-1988. 486. DeStefano F, Chen RT. Autism and measles-mumps-rubella vaccination: controversy laid to rest? CNS Drugs 2001; 15(11): 831-837. 42 487. DeStefano F, Thompson WW. MMR vaccination and autism: is there a link? Expert Opin Drug Saf 2002; 1(2): 115-120. 488. D'Souza Y, Fombonne E, Ward BJ. No evidence of persisting measles virus in peripheral blood mononuclear cells from children with autism spectrum disorder. Pediatrics 2006; 118(4): 1664-1675. 489. Dubey AP, Banerjee S. Measles, mumps, rubella (MMR) vaccine. Indian J Pediatr 2003; 70(7): 579-584. 490. Eaton L. New research on autism and measles "proves nothing". BMJ 2002; 324(7333): 315. 491. Eden OB. Autism, bowel inflammation, and measles. Lancet 2002; 359(9323): 2113. 492. Elliman DA, Bedford HE. Measles, mumps and rubella vaccine, autism and inflammatory bowel disease: advising concerned parents. Paediatr Drugs 2002; 4(10): 631-635. 493. Elphinstone P. Autism, bowel inflammation, and measles. Lancet 2002; 359(9323): 2112. 494. Fisher BL. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9112): 1357-1358. 495. Fombonne E. Inflammatory bowel disease and autism. Lancet 1998; 351(9107): 955. 496. Fombonne E, Chakrabarti S. No evidence for a new variant of measles-mumps-rubellainduced autism. Pediatrics 2001; 108(4): E58. 497. Gerber JS, Offit PA. Vaccines and autism: a tale of shifting hypotheses. Clin Infect Dis 2009; 48(4): 456-461. 498. Guzzi G. Of vaccine-autism, thimerosal, and metallothioneins. Pediatr Allergy Immunol 2007; 18(1): 88; author reply 89. 499. Halsey NA, Hyman SL. Measles-mumps-rubella vaccine and autistic spectrum disorder: report from the New Challenges in Childhood Immunizations Conference convened in Oak Brook, Illinois, June 12-13, 2000. Pediatrics 2001; 107(5): E84. 500. Kastner JL, Gellin BG. Measles-mumps-rubella vaccine and autism: the rise (and fall?) of a hypothesis. Pediatr Ann 2001; 30(7): 408-415. 43 501. Kawashima H, Mori T, Kashiwagi Y, Takekuma K, Hoshika A, Wakefield A. Detection and sequencing of measles virus from peripheral mononuclear cells from patients with inflammatory bowel disease and autism. Dig Dis Sci 2000; 45(4): 723-729. 502. Kiln MR. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9112): 1358. 503. Lee JW, Melgaard B, Clements CJ, Kane M, Mulholland EK, Olive JM. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9106): 905; author reply 908-909. 504. Levenson D. Institute of Medicine rejects vaccine-autism link. Rep Med Guidel Outcomes Res 2004; 15(11): 9-10, 12. 505. Libbey JE, Coon HH, Kirkman NJ, Sweeten TL, Miller JN, Lainhart JE et al. Are there altered antibody responses to measles, mumps, or rubella viruses in autism? J Neurovirol 2007; 13(3): 252-259. 506. Lindley KJ, Milla PJ. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9106): 907-908; author reply 908-909. 507. MacIntyre CR, McIntyre PB. MMR, autism and inflammatory bowel disease: responding to patient concerns using an evidence-based framework. Med J Aust 2001; 175(3): 127128. 508. Miller E. Measles-mumps-rubella vaccine and the development of autism. Semin Pediatr Infect Dis 2003; 14(3): 199-206. 509. Nokleby H. [Vaccination, inflammatory bowel disease and autism--is there a connection?]. Tidsskr Nor Laegeforen 2001; 121(23): 2679. 510. O'Brien SJ, Jones IG, Christie P. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9106): 906-907; author reply 908-909. 511. Payne C, Mason B. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9106): 907; author reply 908-909. 512. Peltola H, Patja A, Leinikki P, Valle M, Davidkin I, Paunio M. No evidence for measles, mumps, and rubella vaccine-associated inflammatory bowel disease or autism in a 14year prospective study. Lancet 1998; 351(9112): 1327-1328. 513. Purssell E. Exploring the evidence surrounding the debate on MMR and autism. Br J Nurs 2004; 13(14): 834-838. 44 514. Richmond P, Goldblatt D. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9112): 1355-1356; author reply 1356. 515. Rouse A. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9112): 1356. 516. Schultz ST, Klonoff-Cohen HS, Wingard DL, Akshoomoff NA, Macera CA, Ji M. Acetaminophen (paracetamol) use, measles-mumps-rubella vaccination, and autistic disorder: the results of a parent survey. Autism 2008; 12(3): 293-307. 517. Sinclair L. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9112): 1355; author reply 1356. 518. Smeeth L, Hall A, Rodrigues L, Cook C, Fombonne E. Autism, bowel inflammation, and measles. Lancet 2002; 359(9323): 2112-2113. 519. Spitzer WO. A sixty day war of words: is MMR linked to autism? Adverse Drug React Toxicol Rev 2001; 20(1): 47-55. 520. Strauss B, Bigham M. Does measles-mumps-rubella (MMR) vaccination cause inflammatory bowel disease and autism? Can Commun Dis Rep 2001; 27(8): 65-72. 521. Taylor B, Lingam R, Simmons A, Stowe J, Miller E, Andrews N. Autism and MMR vaccination in North London; no causal relationship. Mol Psychiatry 2002; 7 Suppl 2: S7-8. 522. Tettenborn MA. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9112): 1357. 523. Thrower D. Autism, bowel inflammation, and measles. Lancet 2002; 359(9323): 2113. 524. Thrower D. MMR and autism: the debate continues. Lancet 2004; 363(9408): 567-568; author reply 568-569. 525. Wakefield AJ. Enterocolitis, autism and measles virus. Mol Psychiatry 2002; 7 Suppl 2: S44-46. 526. Wakefield AJ. Measles, mumps, and rubella vaccination and autism. N Engl J Med 2003; 348(10): 951-954; author reply 951-954. 527. Wakefield AJ, Harvey P, Linnell J. MMR--responding to retraction. Lancet 2004; 363(9417): 1327-1328; discussion 1328. 528. Wakefield AJ, Montgomery SM. Autism, viral infection and measles-mumps-rubella vaccination. Isr Med Assoc J 1999; 1(3): 183-187. 45 529. Wakefield AJ, Murch SH, Anthony A, Linnell J, Casson DM, Malik M et al. Ileallymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998; 351(9103): 637-641. 530. Walker DR. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9112): 1355; author reply 1356. 531. Walker-Smith J. Autism, bowel inflammation, and measles. Lancet 2002; 359(9307): 705-706. 532. Walker-Smith JA. Autism, inflammatory bowel disease, and MMR vaccine. Lancet 1998; 351(9112): 1356-1357. 533. Rose S, Melnyk S, Savenka A, Hubanks A, Jernigan S, Cleves MA et al. The frequency of polymorphisms affecting lead and mercury toxicity among children with autism. Am J Biochem Biotech 2008; 4(2): 85-94. 534. Chauhan A, Sheikh A, Chauhan V. Increased copper-mediated oxidation of membrane phosphatidylethanolamine in autism. American Journal of Biochemistry and Biotechnology 2008; 4(2): 95-100. 535. Pasca SP, Nemes B, Vlase L, Gagyi CE, Dronca E, Miu AC et al. High levels of homocysteine and low serum paraoxonase 1 arylesterase activity in children with autism. Life Sci 2006; 78(19): 2244-2248. 536. Chauhan A, Chauhan V, Brown WT, Cohen I. Oxidative stress in autism: increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin--the antioxidant proteins. Life Sci 2004; 75(21): 2539-2549. 537. Adams JB, Baral M, Geis E, Mitchell J, Ingram J, Hensley A et al. The severity of autism is associated with toxic metal body burden and red blood cell glutathione levels. Journal of Toxicology 2009; 2009: 1-7. 538. Al-Gadani Y, El-Ansary A, Attas O, Al-Ayadhi L. Metabolic biomarkers related to oxidative stress and antioxidant status in Saudi autistic children. Clin Biochem 2009; 42(10-11): 1032-1040. 539. Al-Mosalem OA, El-Ansary A, Attas O, Al-Ayadhi L. Metabolic biomarkers related to energy metabolism in Saudi autistic children. Clin Biochem 2009; 42(10-11): 949-957. 540. Buyske S, Williams TA, Mars AE, Stenroos ES, Ming SX, Wang R et al. Analysis of case-parent trios at a locus with a deletion allele: association of GSTM1 with autism. BMC Genet 2006; 7(1): 8. 46 541. El-Ansary A, Al-Daihan S, Al-Dbass A, Al-Ayadhi L. Measurement of selected ions related to oxidative stress and energy metabolism in Saudi autistic children. Clin Biochem 2010; 43(1-2): 63-70. 542. Fernell E, Watanabe Y, Adolfsson I, Tani Y, Bergstrom M, Hartvig P et al. Possible effects of tetrahydrobiopterin treatment in six children with autism--clinical and positron emission tomography data: a pilot study. Dev Med Child Neurol 1997; 39(5): 313-318. 543. Frye RE, Huffman LC, Elliott GR. Tetrahydrobiopterin as a novel therapeutic intervention for autism. Neurotherapeutics 2010; 7(3): 241-249. 544. Geier DA, Geier MR. A clinical and laboratory evaluation of methionine cycletranssulfuration and androgen pathway markers in children with autistic disorders. Horm Res 2006; 66(4): 182-188. 545. Geier DA, Kern JK, Garver CR, Adams JB, Audhya T, Geier MR. A prospective study of transsulfuration biomarkers in autistic disorders. Neurochem Res 2009; 34(2): 386-393. 546. Geier DA, Kern JK, Garver CR, Adams JB, Audhya T, Nataf R et al. Biomarkers of environmental toxicity and susceptibility in autism. J Neurol Sci 2009; 280(1-2): 101108. 547. Golse B, Debray-Ritzen P, Durosay P, Puget K, Michelson AM. [Alterations in two enzymes: superoxide dismutase and glutathion peroxidase in developmental infantile psychosis (infantile autism) (author's transl)]. Rev Neurol (Paris) 1978; 134(11): 699705. 548. Goodman AB. A family history study of schizophrenia spectrum disorders suggests new candidate genes in schizophrenia and autism. Psychiatr Q 1994; 65(4): 287-297. 549. James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW et al. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr 2004; 80(6): 1611-1617. 550. James SJ, Melnyk S, Jernigan S, Cleves MA, Halsted CH, Wong DH et al. Metabolic endophenotype and related genotypes are associated with oxidative stress in children with autism. Am J Med Genet B Neuropsychiatr Genet 2006; 141(8): 947-956. 551. James SJ, Melnyk S, Jernigan S, Hubanks A, Rose S, Gaylor DW. Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism. J Autism Dev Disord 2008; 38(10): 1966-1975. 552. James SJ, Rose S, Melnyk S, Jernigan S, Blossom S, Pavliv O et al. Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism. FASEB J 2009; 23(8): 2374-2383. 47 553. Krajcovicova-Kudlackova M, Valachovicova M, Mislanova C, Hudecova Z, Sustrova M, Ostatnikova D. Plasma concentrations of selected antioxidants in autistic children and adolescents. Bratisl Lek Listy 2009; 110(4): 247-250. 554. Mazur-Kolecka B, Cohen IL, Jenkins EC, Flory M, Merz G, Ted Brown W et al. Sera from children with autism alter proliferation of human neuronal progenitor cells exposed to oxidation. Neurotox Res 2009; 16(1): 87-95. 555. Meguid NA, Dardir AA, Abdel-Raouf ER, Hashish A. Evaluation of Oxidative Stress in Autism: Defective Antioxidant Enzymes and Increased Lipid Peroxidation. Biol Trace Elem Res 2010. 556. Ming X, Johnson WG, Stenroos ES, Mars A, Lambert GH, Buyske S. Genetic variant of glutathione peroxidase 1 in autism. Brain Dev 2009. 557. Ming X, Stein TP, Brimacombe M, Johnson WG, Lambert GH, Wagner GC. Increased excretion of a lipid peroxidation biomarker in autism. Prostaglandins Leukot Essent Fatty Acids 2005; 73(5): 379-384. 558. Palmieri L, Papaleo V, Porcelli V, Scarcia P, Gaita L, Sacco R et al. Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1. Mol Psychiatry 2010; 15(1): 38-52. 559. Pasca SP, Dronca E, Kaucsar T, Craciun EC, Endreffy E, Ferencz BK et al. One Carbon Metabolism Disturbances and the C677T MTHFR Gene Polymorphism in Children with Autism Spectrum Disorders. J Cell Mol Med 2008. 560. Sajdel-Sulkowska EM, Xu M, McGinnis W, Koibuchi N. Brain Region-Specific Changes in Oxidative Stress and Neurotrophin Levels in Autism Spectrum Disorders (ASD). Cerebellum 2010. 561. Serajee FJ, Nabi R, Zhong H, Huq M. Polymorphisms in xenobiotic metabolism genes and autism. J Child Neurol 2004; 19(6): 413-417. 562. Sogut S, Zoroglu SS, Ozyurt H, Yilmaz HR, Ozugurlu F, Sivasli E et al. Changes in nitric oxide levels and antioxidant enzyme activities may have a role in the pathophysiological mechanisms involved in autism. Clin Chim Acta 2003; 331(1-2): 111117. 563. Tordjman S, Anderson GM, Pichard N, Charbuy H, Touitou Y. Nocturnal excretion of 6sulphatoxymelatonin in children and adolescents with autistic disorder. Biol Psychiatry 2005; 57(2): 134-138. 48 564. Torsdottir G, Hreidarsson S, Kristinsson J, Snaedal J, Johannesson T. Ceruloplasmin, superoxide dismutase and copper in autistic patients. Basic Clin Pharmacol Toxicol 2005; 96(2): 146-148. 565. Williams TA, Mars AE, Buyske SG, Stenroos ES, Wang R, Factura-Santiago MF et al. Risk of autistic disorder in affected offspring of mothers with a glutathione S-transferase P1 haplotype. Arch Pediatr Adolesc Med 2007; 161(4): 356-361. 566. Yorbik O, Sayal A, Akay C, Akbiyik DI, Sohmen T. Investigation of antioxidant enzymes in children with autistic disorder. Prostaglandins Leukot Essent Fatty Acids 2002; 67(5): 341-343. 567. Youn SI, Jin SH, Kim SH, Lim S. Porphyrinuria in Korean children with autism: correlation with oxidative stress. J Toxicol Environ Health A 2010; 73(10): 701-710. 568. Zoroglu SS, Armutcu F, Ozen S, Gurel A, Sivasli E, Yetkin O et al. Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism. Eur Arch Psychiatry Clin Neurosci 2004; 254(3): 143-147. 569. Clark-Taylor T, Clark-Taylor BE. Is autism a disorder of fatty acid metabolism? Possible dysfunction of mitochondrial beta-oxidation by long chain acyl-CoA dehydrogenase. Med Hypotheses 2004; 62(6): 970-975. 570. Cohen BI. Ammonia (NH3), nitric oxide (NO) and nitrous oxide (N2O)--the connection with infantile autism. Autism 2006; 10(2): 221-223. 571. Reed MC, Thomas RL, Pavisic J, James SJ, Ulrich CM, Nijhout HF. A mathematical model of glutathione metabolism. Theor Biol Med Model 2008; 5: 8. 572. Braam W, Smits MG, Didden R, Korzilius H, Van Geijlswijk IM, Curfs LM. Exogenous melatonin for sleep problems in individuals with intellectual disability: a meta-analysis. Dev Med Child Neurol 2009; 51(5): 340-349. 573. Rossignol DA, Bradstreet JJ. Evidence of mitochondrial dysfunction in autism and implications for treatment. Am J Biochem Biotech 2008; 4(2): 208-217. 574. Ming X, Cheh MA, Yochum CL, Halladay AK, Wagner GC. Evidence of oxidative stress in autism derived from animal models. American Journal of Biochemistry and Biotechnology 2008; 4(2): 218-225. 575. Yochum CL, Wagner GC. Autism and Parkinson's disease: Animal models and a common etiological mechanism. Chinese Journal of Physiology 2009; 52(4): 236-249. 576. Akyol O, Zoroglu SS, Armutcu F, Sahin S, Gurel A. Nitric oxide as a physiopathological factor in neuropsychiatric disorders. In Vivo 2004; 18(3): 377-390. 49 577. Aschner M, Syversen T, Souza DO, Rocha JB. Metallothioneins: mercury speciesspecific induction and their potential role in attenuating neurotoxicity. Exp Biol Med (Maywood) 2006; 231(9): 1468-1473. 578. Chauhan A, Chauhan V. Oxidative stress in autism. Pathophysiology 2006; 13(3): 171181. 579. Deth R, Muratore C, Benzecry J, Power-Charnitsky VA, Waly M. How environmental and genetic factors combine to cause autism: A redox/methylation hypothesis. Neurotoxicology 2008; 29(1): 190-201. 580. Ghanizadeh A. Oxidative stress may mediate association of stereotypy and immunity in autism, a novel explanation with clinical and research implications. J Neuroimmunol 2010. 581. Johannesson T, Kristinsson J, Snaedal J. [Neurodegenerative diseases, antioxidative enzymes and copper. A review of experimental research.]. Laeknabladid 2003; 89(9): 659-671. 582. Johnson S. Micronutrient accumulation and depletion in schizophrenia, epilepsy, autism and Parkinson's disease? Med Hypotheses 2001; 56(5): 641-645. 583. Kern JK, Jones AM. Evidence of toxicity, oxidative stress, and neuronal insult in autism. J Toxicol Environ Health B Crit Rev 2006; 9(6): 485-499. 584. Kidd PM. Omega-3 DHA and EPA for cognition, behavior, and mood: clinical findings and structural-functional synergies with cell membrane phospholipids. Altern Med Rev 2007; 12(3): 207-227. 585. Kinney DK, Barch DH, Chayka B, Napoleon S, Munir KM. Environmental risk factors for autism: do they help cause de novo genetic mutations that contribute to the disorder? Med Hypotheses 2010; 74(1): 102-106. 586. McGinnis WR. Oxidative stress in autism. Altern Ther Health Med 2005; 11(1): 19. 587. McGinnis WR. Could oxidative stress from psychosocial stress affect neurodevelopment in autism? J Autism Dev Disord 2007; 37(5): 993-994. 588. McGinnis WR, Audhya T, Walsh WJ, Jackson JA, McLaren-Howard J, Lewis A et al. Discerning the Mauve Factor, Part 1. Altern Ther Health Med 2008; 14(2): 40-50. 589. McGinnis WR, Audhya T, Walsh WJ, Jackson JA, McLaren-Howard J, Lewis A et al. Discerning the Mauve factor, Part 2. Altern Ther Health Med 2008; 14(3): 56-62. 50 590. Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol 2008: 1-26. 591. Palmieri L, Persico AM. Mitochondrial dysfunction in autism spectrum disorders: Cause or effect? Biochim Biophys Acta 2010; 1797(6-7): 1130-1137. 592. Tsaluchidu S, Cocchi M, Tonello L, Puri BK. Fatty acids and oxidative stress in psychiatric disorders. BMC Psychiatry 2008; 8 Suppl 1: S5. 593. Villagonzalo KA, Dodd S, Dean O, Gray K, Tonge B, Berk M. Oxidative pathways as a drug target for the treatment of autism. Expert Opin Ther Targets 2010. 594. Adams JB, Baral M, Geis E, Mitchell J, Ingram J, Hensley A et al. Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: part B - behavioral results. BMC Clin Pharmacol 2009; 9: 17. 595. Bertoglio K, Jill James S, Deprey L, Brule N, Hendren RL. Pilot study of the effect of methyl B12 treatment on behavioral and biomarker measures in children with autism. J Altern Complement Med 2010; 16(5): 555-560. 596. Komori H, Matsuishi T, Yamada S, Yamashita Y, Ohtaki E, Kato H. Cerebrospinal fluid biopterin and biogenic amine metabolites during oral R-THBP therapy for infantile autism. J Autism Dev Disord 1995; 25(2): 183-193. 597. O'Hara NH, Szakacs GM. The recovery of a child with autism spectrum disorder through biomedical interventions. Altern Ther Health Med 2008; 14(6): 42-44. 598. James SJ, Melnyk S, Fuchs G, Reid T, Jernigan S, Pavliv O et al. Efficacy of methylcobalamin and folinic acid treatment on glutathione redox status in children with autism. Am J Clin Nutr 2009; 89(1): 425-430. 599. Dolske MC, Spollen J, McKay S, Lancashire E, Tolbert L. A preliminary trial of ascorbic acid as supplemental therapy for autism. Prog Neuropsychopharmacol Biol Psychiatry 1993; 17(5): 765-774. 600. Hunter JW, Mullen GP, McManus JR, Heatherly JM, Duke A, Rand JB. Neuroligindeficient mutants of C. elegans have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicity. Dis Model Mech 2010. 601. Bechara EG, Didiot MC, Melko M, Davidovic L, Bensaid M, Martin P et al. A novel function for fragile X mental retardation protein in translational activation. PLoS Biol 2009; 7(1): e16. 602. MacFabe DF, Rodríguez-Capote K, Hoffman JE, Franklin AE, Mohammad-Asef Y, Taylor AR et al. A novel rodent model of autism: intraventricular infusions of propionic 51 acid increase locomotor activity and induce neuroinflammation and oxidative stress in discrete regions of adult rat brain Am J Biochem Biotech 2008; 4(2): 146-166. 603. Abbott LC, Nahm SS. Neuronal nitric oxide synthase expression in cerebellar mutant mice. Cerebellum 2004; 3(3): 141-151. 604. Yochum CL, Bhattacharya P, Patti L, Mirochnitchenko O, Wagner GC. Animal model of autism using GSTM1 knockout mice and early post-natal sodium valproate treatment. Behav Brain Res 2010. 605. Battisti C, Formichi P, Tripodi SA, Meloni I, Mangiavacchi P, Zappella M et al. Lymphoblastoid cell lines of Rett syndrome patients exposed to oxidative-stress-induced apoptosis. Brain Dev 2004; 26(6): 384-388. 606. Formichi P, Battisti C, Dotti MT, Hayek G, Zappella M, Federico A. Vitamin E serum levels in Rett syndrome. J Neurol Sci 1998; 156(2): 227-230. 607. Haas RH, Light M, Rice M, Barshop BA. Oxidative metabolism in Rett syndrome: 1. Clinical studies. Neuropediatrics 1995; 26(2): 90-94. 608. Haas RH, Nasirian F, Hua X, Nakano K, Hennessy M. Oxidative metabolism in Rett syndrome: 2. Biochemical and molecular studies. Neuropediatrics 1995; 26(2): 95-99. 609. Kelly GS. L-Carnitine: therapeutic applications of a conditionally-essential amino acid. Altern Med Rev 1998; 3(5): 345-360. 610. Plochl E, Sperl W, Wermuth B, Colombo JP. [Carnitine deficiency and carnitine therapy in a patient with Rett syndrome]. Klin Padiatr 1996; 208(3): 129-134. 611. Sierra C, Vilaseca MA, Brandi N, Artuch R, Mira A, Nieto M et al. Oxidative stress in Rett syndrome. Brain Dev 2001; 23 Suppl 1: S236-239. 612. Sofic E, Riederer P, Killian W, Rett A. Reduced concentrations of ascorbic acid and glutathione in a single case of Rett syndrome: a postmortem brain study. Brain Dev 1987; 9(5): 529-531. 613. Stradomska TJ, Tylki-Szymanska A, Bentkowski Z. Very long-chain fatty acids in Rett syndrome. Eur J Pediatr 1999; 158(3): 226-229. 614. De Felice C, Ciccoli L, Leoncini S, Signorini C, Rossi M, Vannuccini L et al. Systemic oxidative stress in classic Rett syndrome. Free Radic Biol Med 2009; 47(4): 440-448. 615. Blasi F, Bacchelli E, Carone S, Toma C, Monaco AP, Bailey AJ et al. SLC25A12 and CMYA3 gene variants are not associated with autism in the IMGSAC multiplex family sample. Eur J Hum Genet 2006; 14(1): 123-126. 52 616. Chien WH, Wu YY, Gau SS, Huang YS, Soong WT, Chiu YN et al. Association study of the SLC25A12 gene and autism in Han Chinese in Taiwan. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34(1): 189-192. 617. Kent L, Gallagher L, Elliott HR, Mowbray C, Chinnery PF. An investigation of mitochondrial haplogroups in autism. Am J Med Genet B Neuropsychiatr Genet 2008; 147B(6): 987-989. 618. Kent L, Lambert C, Pyle A, Elliott H, Wheelwright S, Baron-Cohen S et al. The mitochondrial DNA A3243A>G mutation must be an infrequent cause of Asperger syndrome. J Pediatr 2006; 149(2): 280-281. 619. Petek E, Schwarzbraun T, Noor A, Patel M, Nakabayashi K, Choufani S et al. Molecular and genomic studies of IMMP2L and mutation screening in autism and Tourette syndrome. Mol Genet Genomics 2007; 277(1): 71-81. 620. Rabionet R, McCauley JL, Jaworski JM, Ashley-Koch AE, Martin ER, Sutcliffe JS et al. Lack of association between autism and SLC25A12. Am J Psychiatry 2006; 163(5): 929931. 621. Taurines R, Thome J, Duvigneau JC, Forbes-Robertson S, Yang L, Klampfl K et al. Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia. Eur Child Adolesc Psychiatry 2010; 19(5): 441-448. 622. Nielsen JB, Toft PB, Reske-Nielsen E, Jensen KE, Christiansen P, Thomsen C et al. Cerebral magnetic resonance spectroscopy in Rett syndrome. Failure to detect mitochondrial disorder. Brain Dev 1993; 15(2): 107-112. 623. Yap IK, Angley M, Veselkov KA, Holmes E, Lindon JC, Nicholson JK. Urinary metabolic phenotyping differentiates children with autism, from their unaffected siblings and age-matched controls. J Proteome Res 2010. 624. Marin-Garcia J, Ananthakrishnan R, Goldenthal MJ, Filiano JJ, Sarnat HB. Skeletal muscle mitochondrial defects in nonspecific neurologic disorders. Pediatr Neurol 1999; 21(2): 538-542. 625. Nissenkorn A, Zeharia A, Lev D, Watemberg N, Fattal-Valevski A, Barash V et al. Neurologic presentations of mitochondrial disorders. J Child Neurol 2000; 15(1): 44-48. 626. Prevalence of autism spectrum disorders in subjects with definite diagnosis of mitochondrial cytopathies. Proceedings of the The American Society of Human Genetics 59th Annual Meeting2009; Honolulu, Hawaii. 53 627. Gargus JJ, Lerner MA. Familial autism with primary carnitine deficiency, sudden death, hypotonia and hypochromic anemia. Am J Human Gen 1997; 61: A98. 628. Shaw W, Kassen E, Chaves E. Increased urinary excretion of analogs of Krebs cycle metabolites and arabinose in two brothers with autistic features. Clin Chem 1995; 41(8 Pt 1): 1094-1104. 629. Serajee FJ, Zhang H, Huq A. Prevalence of common mitochondrial point mutations in autism. Neuropediatrics 2006; 37(Suppl 1): S127. 630. El-Ansary A, Al-Daihan S, Al-Dabas A, Al-Ayadhi L. Activities of key glycolytic enzymes in the plasma of Saudi autistic patients. Open Access Journal of Clinical Trials 2010; 2010(2): 49-57. 631. Chauhan A, Essa MM, Muthaiyah B, Brown WT, Chauhan V. Mitochondrial abnormalities in lymphoblasts from autism: P1-01-03. Journal of Neurochemistry 2009; 109 (Suppl. 1): 273. 632. Ramoz N, Cai G, Reichert JG, Silverman JM, Buxbaum JD. An analysis of candidate autism loci on chromosome 2q24-q33: evidence for association to the STK39 gene. Am J Med Genet B Neuropsychiatr Genet 2008; 147B(7): 1152-1158. 633. Maussion G, Carayol J, Lepagnol-Bestel AM, Tores F, Loe-Mie Y, Milbreta U et al. Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. Hum Mol Genet 2008; 17(16): 2541-2551. 634. Benzecry JM, Deth R, Holtzman D. Are autistic spectrum disorders an expression of mitochondrial encephalopathies? Mitochondrion 2009; 9(1): 62. 635. Mostafa GA, El-Gamal HA, El-Wakkad ASE, El-Shorbagy OE, Hamza MM. Polyunsaturated fatty acids, carnitine and lactate as biological markers of brain energy in autistic children. Int J Child Neuropsychiatry 2005; 2(2): 179-188. 636. Maestrini E, Pagnamenta AT, Lamb JA, Bacchelli E, Sykes NH, Sousa I et al. Highdensity SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility. Mol Psychiatry 2009. 637. Ji L, Chauhan A, Brown WT, Chauhan V. Increased activities of Na+/K+-ATPase and Ca2+/Mg2+-ATPase in the frontal cortex and cerebellum of autistic individuals. Life Sci 2009; 85(23-26): 788-793. 638. Minshew NJ, Goldstein G, Dombrowski SM, Panchalingam K, Pettegrew JW. A preliminary 31P MRS study of autism: evidence for undersynthesis and increased degradation of brain membranes. Biol Psychiatry 1993; 33(11-12): 762-773. 54 639. Aldred S, Moore KM, Fitzgerald M, Waring RH. Plasma amino acid levels in children with autism and their families. J Autism Dev Disord 2003; 33(1): 93-97. 640. Fernell E, Karagiannakis A, Edman G, Bjerkenstedt L, Wiesel FA, Venizelos N. Aberrant amino acid transport in fibroblasts from children with autism. Neurosci Lett 2007; 418(1): 82-86. 641. Wolanczyk T, Ostrowska-Galemba K, Mikulska J, Komender J, Jagielska G, Tomaszewicz-Libudzic C. [Features of autism, autistic traits, autism: retrospective analysis of clinical symptoms in children treated in the Pediatric Psychiatric Clinic]. Psychiatr Pol 2001; 35(1): 59-69. 642. Moreno H, Borjas L, Arrieta A, Sáez L, Prassad A, Estévez J et al. Heterogeneidad clínica del síndrome autista: un estudio en sesenta familias [Clinical heterogeneity of the autistic syndrome: a study of 60 families]. Invest clin 1992; 33(1): 13-31. 643. Chugani DC, Sundram BS, Behen M, Lee ML, Moore GJ. Evidence of altered energy metabolism in autistic children. Prog Neuropsychopharmacol Biol Psychiatry 1999; 23(4): 635-641. 644. Guevara-Campos J, Gonzalez-Guevara L, Briones P, Lopez-Gallardo E, Bulan N, RuizPesini E et al. Autism associated to a deficiency of complexes III and IV of the mitochondrial respiratory chain. Invest Clin 2010; 51(3): 423-431. 645. Coleman M, Blass JP. Autism and lactic acidosis. J Autism Dev Disord 1985; 15(1): 1-8. 646. Laszlo A, Horvath E, Eck E, Fekete M. Serum serotonin, lactate and pyruvate levels in infantile autistic children. Clin Chim Acta 1994; 229(1-2): 205-207. 647. Germano E, Gagliano A, Magazu A, Calarese T, Calabro ME, Bonsignore M et al. [Neurobiology of autism: Study of a sample of autistic children]. Minerva Pediatr 2006; 58(2): 109-120. 648. Castro-Gago M, Blanco-Barca O, Gomez-Lado C, Pintos-Martinez E, Campos-Gonzalez Y, Eiris-Punal J. [Association between autistic spectrum and mitochondrial pathology]. Rev Neurol 2008; 47(1): 52-53. 649. Connolly BS, Feigenbaum AS, Robinson BH, Dipchand AI, Simon DK, Tarnopolsky MA. MELAS syndrome, cardiomyopathy, rhabdomyolysis, and autism associated with the A3260G mitochondrial DNA mutation. Biochem Biophys Res Commun 2010; 402(2): 443-447. 650. Correia C, Coutinho AM, Diogo L, Grazina M, Marques C, Miguel T et al. Brief report: High frequency of biochemical markers for mitochondrial dysfunction in autism: no 55 association with the mitochondrial aspartate/glutamate carrier SLC25A12 gene. J Autism Dev Disord 2006; 36(8): 1137-1140. 651. Ezugha H, Goldenthal M, Valencia I, Anderson CE, Legido A, Marks H. 5q14.3 Deletion Manifesting as Mitochondrial Disease and Autism: Case Report. J Child Neurol 2010. 652. Fayed N, Modrego PJ. Comparative study of cerebral white matter in autism and attention-deficit/hyperactivity disorder by means of magnetic resonance spectroscopy. Acad Radiol 2005; 12(5): 566-569. 653. Filipek PA, Juranek J, Nguyen MT, Cummings C, Gargus JJ. Relative carnitine deficiency in autism. J Autism Dev Disord 2004; 34(6): 615-623. 654. Filipek PA, Juranek J, Smith M, Mays LZ, Ramos ER, Bocian M et al. Mitochondrial dysfunction in autistic patients with 15q inverted duplication. Ann Neurol 2003; 53(6): 801-804. 655. Filiano JJ, Goldenthal MJ, Rhodes CH, Marin-Garcia J. Mitochondrial dysfunction in patients with hypotonia, epilepsy, autism, and developmental delay: HEADD syndrome. J Child Neurol 2002; 17(6): 435-439. 656. Giulivi C, Zhang YF, Omanska-Klusek A, Ross-Inta C, Wong S, Hertz-Picciotto I et al. Mitochondrial dysfunction in autism. JAMA 2010; 304(21): 2389-2396. 657. Graf WD, Marin-Garcia J, Gao HG, Pizzo S, Naviaux RK, Markusic D et al. Autism associated with the mitochondrial DNA G8363A transfer RNA(Lys) mutation. J Child Neurol 2000; 15(6): 357-361. 658. Holtzman D. Autistic spectrum disorders and mitochondrial encephalopathies. Acta Paediatr 2008; 97(7): 859-860. 659. Kajita M, Iwase K, Matsumoto M, Kuhara T, Sinka T, Matsumoto I. [Clinical and biochemical studies in a case of acute encephalopathy associated with calcium hopanthenate administration]. No To Hattatsu 1990; 22(3): 267-273. 660. Lepagnol-Bestel AM, Maussion G, Boda B, Cardona A, Iwayama Y, Delezoide AL et al. SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects. Mol Psychiatry 2008; 13(4): 385-397. 661. Marui T, Funatogawa I, Koishi S, Yamamoto K, Matsumoto H, Hashimoto O et al. The NADH-ubiquinone oxidoreductase 1 alpha subcomplex 5 (NDUFA5) gene variants are associated with autism. Acta Psychiatr Scand 2010. 56 662. Oliveira G, Ataide A, Marques C, Miguel TS, Coutinho AM, Mota-Vieira L et al. Epidemiology of autism spectrum disorder in Portugal: prevalence, clinical characterization, and medical conditions. Dev Med Child Neurol 2007; 49(10): 726-733. 663. Oliveira G, Diogo L, Grazina M, Garcia P, Ataide A, Marques C et al. Mitochondrial dysfunction in autism spectrum disorders: a population-based study. Dev Med Child Neurol 2005; 47(3): 185-189. 664. Pancrudo J, Shanske S, Bonilla E, Daras M, Akman HO, Krishna S et al. Mitochondrial encephalomyopathy due to a novel mutation in the tRNAGlu of mitochondrial DNA. J Child Neurol 2007; 22(7): 858-862. 665. Pancrudo J, Shanske S, Coku J, Lu J, Mardach R, Akman O et al. Mitochondrial myopathy associated with a novel mutation in mtDNA. Neuromuscul Disord 2007; 17(8): 651-654. 666. Poling JS, Frye RE, Shoffner J, Zimmerman AW. Developmental regression and mitochondrial dysfunction in a child with autism. J Child Neurol 2006; 21(2): 170-172. 667. Pons R, Andreu AL, Checcarelli N, Vila MR, Engelstad K, Sue CM et al. Mitochondrial DNA abnormalities and autistic spectrum disorders. J Pediatr 2004; 144(1): 81-85. 668. Ramoz N, Reichert JG, Smith CJ, Silverman JM, Bespalova IN, Davis KL et al. Linkage and association of the mitochondrial aspartate/glutamate carrier SLC25A12 gene with autism. Am J Psychiatry 2004; 161(4): 662-669. 669. Segurado R, Conroy J, Meally E, Fitzgerald M, Gill M, Gallagher L. Confirmation of association between autism and the mitochondrial aspartate/glutamate carrier SLC25A12 gene on chromosome 2q31. Am J Psychiatry 2005; 162(11): 2182-2184. 670. Shoffner J, Hyams L, Langley GN, Cossette S, Mylacraine L, Dale J et al. Fever plus mitochondrial disease could be risk factors for autistic regression. J Child Neurol 2010; 25(4): 429-434. 671. Silverman JM, Buxbaum JD, Ramoz N, Schmeidler J, Reichenberg A, Hollander E et al. Autism-related routines and rituals associated with a mitochondrial aspartate/glutamate carrier SLC25A12 polymorphism. Am J Med Genet B Neuropsychiatr Genet 2008; 147(3): 408-410. 672. Smith M, Spence MA, Flodman P. Nuclear and mitochondrial genome defects in autisms. Ann N Y Acad Sci 2009; 1151: 102-132. 673. Tsao CY, Mendell JR. Autistic disorder in 2 children with mitochondrial disorders. J Child Neurol 2007; 22(9): 1121-1123. 57 674. Turunen JA, Rehnstrom K, Kilpinen H, Kuokkanen M, Kempas E, Ylisaukko-Oja T. Mitochondrial aspartate/glutamate carrier SLC25A12 gene is associated with autism. Autism Res 2008; 1(3): 189-192. 675. Weissman JR, Kelley RI, Bauman ML, Cohen BH, Murray KF, Mitchell RL et al. Mitochondrial disease in autism spectrum disorder patients: a cohort analysis. PLoS ONE 2008; 3(11): e3815. 676. Poling JS. Vaccines and autism revisited. N Engl J Med 2008; 359(6): 655; author reply 656. 677. Haas RH. Autism and mitochondrial disease. Dev Disabil Res Rev 2010; 16(2): 144-153. 678. Gargus JJ, Imtiaz F. Mitochondrial energy-deficient endophenotype in autism. Am J Biochem Biotech 2008; 4(2): 198-207. 679. Benvenuto A, Moavero R, Alessandrelli R, Manzi B, Curatolo P. Syndromic autism: causes and pathogenetic pathways. World J Pediatr 2009; 5(3): 169-176. 680. Garcia-Penas JJ. [Autism, epilepsy and mitochondrial disease: points of contact]. Rev Neurol 2008; 46 Suppl 1: S79-85. 681. Gargus JJ. Genetic calcium signaling abnormalities in the central nervous system: seizures, migraine, and autism. Ann N Y Acad Sci 2009; 1151: 133-156. 682. Lerman-Sagie T, Leshinsky-Silver E, Watemberg N, Lev D. Should autistic children be evaluated for mitochondrial disorders? J Child Neurol 2004; 19(5): 379-381. 683. Lombard J. Autism: a mitochondrial disorder? Med Hypotheses 1998; 50(6): 497-500. 684. Lutz RE. Trinucleotide repeat disorders. Semin Pediatr Neurol 2007; 14(1): 26-33. 685. Zecavati N, Spence SJ. Neurometabolic disorders and dysfunction in autism spectrum disorders. Curr Neurol Neurosci Rep 2009; 9(2): 129-136. 686. Su H, Fan W, Coskun PE, Vesa J, Gold JA, Jiang YH et al. Mitochondrial dysfunction in CA1 hippocampal neurons of the UBE3A deficient mouse model for Angelman syndrome. Neurosci Lett 2009. 687. Zhao Y, Fung C, Shin D, Shin BC, Thamotharan S, Sankar R et al. Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders. Mol Psychiatry 2010; 15(3): 286-299. 58 688. Kriaucionis S, Paterson A, Curtis J, Guy J, Macleod N, Bird A. Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome. Mol Cell Biol 2006; 26(13): 5033-5042. 689. Martinez-Munoz C, Rosenberg EH, Jakobs C, Salomons GS. Identification, characterization and cloning of SLC6A8C, a novel splice variant of the creatine transporter gene. Gene 2008; 418(1-2): 53-59. 690. MacFabe DF, Thomas RH, Foley KA, Mepham JR, Tichenoff LJ, Possmayer F. Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: Further development of a potential model of autism spectrum disorders. Journal of Neurochemistry 2010; 113(2): 515-529. 691. Sakurai T, Ramoz N, Barreto M, Gazdoiu M, Takahashi N, Gertner M et al. Slc25a12 disruption alters myelination and neurofilaments: a model for a hypomyelination syndrome and childhood neurodevelopmental disorders. Biol Psychiatry 2010; 67(9): 887-894. 692. Thomas RH, Foley KA, Mepham JR, Tichenoff LJ, Possmayer F, MacFabe DF. Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders. J Neurochem 2010; 113(2): 515-529. 693. Ellaway C, Williams K, Leonard H, Higgins G, Wilcken B, Christodoulou J. Rett syndrome: randomized controlled trial of L-carnitine. J Child Neurol 1999; 14(3): 162167. 694. Ellaway CJ, Peat J, Williams K, Leonard H, Christodoulou J. Medium-term open label trial of L-carnitine in Rett syndrome. Brain Dev 2001; 23 Suppl 1: S85-89. 695. Guideri F, Acampa M, Hayek Y, Zappella M. Effects of acetyl-L-carnitine on cardiac dysautonomia in Rett syndrome: prevention of sudden death? Pediatr Cardiol 2005; 26(5): 574-577. 696. Plioplys AV, Kasnicka I. L-carnitine as a treatment for Rett syndrome. South Med J 1993; 86(12): 1411-1412. 697. Budden SS, Myer EC, Butler IJ. Cerebrospinal fluid studies in the Rett syndrome: biogenic amines and beta-endorphins. Brain Dev 1990; 12(1): 81-84. 698. al-Jarallah AA, Salih MA, al Nasser MN, al Zamil FA, al Gethmi J. Rett syndrome in Saudi Arabia: report of six patients. Ann Trop Paediatr 1996; 16(4): 347-352. 699. Haas RH, Rice MA, Trauner DA, Merritt TA. Therapeutic effects of a ketogenic diet in Rett syndrome. Am J Med Genet Suppl 1986; 1: 225-246. 59 700. Al-Mateen M, Philippart M, Shields WD. Rett syndrome. A commonly overlooked progressive encephalopathy in girls. Am J Dis Child 1986; 140(8): 761-765. 701. Sasaki T, Minagawa M, Yamamoto T, Ichihashi H. A case of the Rett syndrome with acute encephalopathy induced during calcium hopantenate treatment. Brain Dev 1991; 13(1): 52-55. 702. Matsuishi T, Urabe F, Komori H, Yamashita Y, Naito E, Kuroda Y et al. The Rett syndrome and CSF lactic acid patterns. Brain Dev 1992; 14(1): 68-70. 703. Abramovich CM, Prayson RA, McMahon JT, Cohen BH. Ultrastructural examination of the axillary skin biopsy in the diagnosis of metabolic diseases. Hum Pathol 2001; 32(6): 649-655. 704. Armstrong DD. The neuropathology of the Rett syndrome. Brain Dev 1992; 14 Suppl: S89-98. 705. Armstrong J, Pineda M, Monros E. Mutation analysis of 16S rRNA in patients with Rett syndrome. Pediatr Neurol 2000; 23(1): 85-87. 706. Belichenko PV, Wright EE, Belichenko NP, Masliah E, Li HH, Mobley WC et al. Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: evidence for disruption of neuronal networks. J Comp Neurol 2009; 514(3): 240-258. 707. Cardaioli E, Dotti MT, Hayek G, Zappella M, Federico A. Studies on mitochondrial pathogenesis of Rett syndrome: ultrastructural data from skin and muscle biopsies and mutational analysis at mtDNA nucleotides 10463 and 2835. J Submicrosc Cytol Pathol 1999; 31(2): 301-304. 708. Coker SB, Melnyk AR. Rett syndrome and mitochondrial enzyme deficiencies. J Child Neurol 1991; 6(2): 164-166. 709. Condie J, Goldstein J, Wainwright MS. Acquired microcephaly, regression of milestones, mitochondrial dysfunction, and episodic rigidity in a 46,XY male with a de novo MECP2 gene mutation. J Child Neurol 2010; 25(5): 633-636. 710. Dotti MT, Manneschi L, Malandrini A, De Stefano N, Caznerale F, Federico A. Mitochondrial dysfunction in Rett syndrome. An ultrastructural and biochemical study. Brain Dev 1993; 15(2): 103-106. 711. Eeg-Olofsson O, al-Zuhair AG, Teebi AS, al-Essa MM. Abnormal mitochondria in the Rett syndrome. Brain Dev 1988; 10(4): 260-262. 60 712. Eeg-Olofsson O, al-Zuhair AG, Teebi AS, al-Essa MM. Rett syndrome: genetic clues based on mitochondrial changes in muscle. Am J Med Genet 1989; 32(1): 142-144. 713. Eeg-Olofsson O, al-Zuhair AG, Teebi AS, Daoud AS, Zaki M, Besisso MS et al. Rett syndrome: a mitochondrial disease? J Child Neurol 1990; 5(3): 210-214. 714. Eeg-Olofsson O, al-Zuhair AG, Teebi AS, Zaki M, Daoud AS. A boy with the Rett syndrome? Brain Dev 1990; 12(5): 529-532. 715. Ellaway C, Christodoulou J. Rett syndrome: clinical update and review of recent genetic advances. J Paediatr Child Health 1999; 35(5): 419-426. 716. Ellaway CJ, McQuade LR, Christodoulou J. Novel mitochondrial 16S rRNA polymorphism in a girl with Rett syndrome. J Inherit Metab Dis 1999; 22(8): 946-947. 717. Forlani G, Giarda E, Ala U, Di Cunto F, Salani M, Tupler R et al. The MeCP2/YY1 interaction regulates ANT1 expression at 4q35: novel hints for Rett syndrome pathogenesis. Hum Mol Genet 2010; 19(16): 3114-3123. 718. Heilstedt HA, Shahbazian MD, Lee B. Infantile hypotonia as a presentation of Rett syndrome. Am J Med Genet 2002; 111(3): 238-242. 719. Jellinger K, Grisold W, Armstrong D, Rett A. Peripheral nerve involvement in the Rett syndrome. Brain Dev 1990; 12(1): 109-114. 720. Lappalainen R, Riikonen RS. Elevated CSF lactate in the Rett syndrome: cause or consequence? Brain Dev 1994; 16(5): 399-401. 721. Mak SC, Chi CS, Chen CH, Shian WJ. Abnormal mitochondria in Rett syndrome: one case report. Zhonghua Yi Xue Za Zhi (Taipei) 1993; 52(2): 116-119. 722. Matsuishi T, Urabe F, Percy AK, Komori H, Yamashita Y, Schultz RS et al. Abnormal carbohydrate metabolism in cerebrospinal fluid in Rett syndrome. J Child Neurol 1994; 9(1): 26-30. 723. Meng H, Pan H, Qi Y. [Role of mitochondrial lesion in pathogenesis of sporadic rett syndrome]. Zhonghua Yi Xue Za Zhi 2001; 81(11): 662-664. 724. Midro AT, Panasiuk B. [Genetic basis for Rett disease]. Postepy Hig Med Dosw 1997; 51(4): 399-419. 725. Naidu S, Hyman S, Harris EL, Narayanan V, Johns D, Castora F. Rett syndrome studies of natural history and search for a genetic marker. Neuropediatrics 1995; 26(2): 63-66. 61 726. Philippart M. Clinical recognition of Rett syndrome. Am J Med Genet Suppl 1986; 1: 111-118. 727. Qi Y, Liu Z, Jiang S. [Five de novo forms of polymorphisms first found in Chinese mitochondrial genome]. Zhonghua Yi Xue Za Zhi 2001; 81(15): 924-926. 728. Qi Y, Wu X, Tang J, Bao X. [Computerized ribosomal RNA secondary structure modeling of mutants found in Rett syndrome patients and their mothers]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 1999; 16(3): 153-155. 729. Ruch A, Kurczynski TW, Velasco ME. Mitochondrial alterations in Rett syndrome. Pediatr Neurol 1989; 5(5): 320-323. 730. Tang J, Qi Y, Bao X. [Mutation analysis of mitochondrial DNA of children with Rett syndrome]. Zhonghua Yi Xue Za Zhi 1996; 76(9): 684-687. 731. Tang J, Qi Y, Bao XH, Wu XR. Mutational analysis of mitochondrial DNA of children with Rett syndrome. Pediatr Neurol 1997; 17(4): 327-330. 732. Thomas S, Oberholzer V, Wilson J, Hjelm M. The urea cycle in the Rett syndrome. Brain Dev 1990; 12(1): 93-96. 733. Wakai S, Kameda K, Ishikawa Y, Miyamoto S, Nagaoka M, Okabe M et al. Rett syndrome: findings suggesting axonopathy and mitochondrial abnormalities. Pediatr Neurol 1990; 6(5): 339-343. 734. Wallace DC, Fan W. Energetics, epigenetics, mitochondrial genetics. Mitochondrion 2010; 10(1): 12-31. 735. Yoshikawa H, Fueki N, Suzuki H, Sakuragawa N. [Cerebral blood flow and oxygen metabolism in Rett syndrome]. No To Hattatsu 1990; 22(3): 216-222. 736. Williams PG, Hersh JH, Allard A, Sears LL. A controlled study of mercury levels in hair samples of children with autism as compared to their typically developing siblings. Research in Autism Spectrum Disorders 2008; 2: 170-175. 737. Spiker D, Lotspeich L, Hallmayer J, Kraemer HC, Ciaranello RD. Failure to find cytogenetic abnormalities in autistic children whose parents grew up near plastics manufacturing sites. J Autism Dev Disord 1993; 23(4): 681-682. 738. Grether JK, Li SX, Yoshida CK, Croen LA. Antenatal ultrasound and risk of autism spectrum disorders. J Autism Dev Disord 2010; 40(2): 238-245. 739. Clark B, Vandermeer B, Simonetti A, Buka I. Is lead a concern in Canadian autistic children? Paediatr Child Health 2010; 15(1): 17-22. 62 740. Adams JB, Holloway CE, George F, Quig D. Analyses of toxic metals and essential minerals in the hair of Arizona children with autism and associated conditions, and their mothers. Biol Trace Elem Res 2006; 110(3): 193-209. 741. Chang S, Crothers C, Lai S, Lamm S. Pediatric neurobehavioral diseases in Nevada counties with respect to perchlorate in drinking water: an ecological inquiry. Birth Defects Res A Clin Mol Teratol 2003; 67(10): 886-892. 742. Grether J, Croen L, Theis C, Blaxill M, Haley B, Holmes A. Baby hair, mercury toxicity and autism. Int J Toxicol 2004; 23(4): 275-276. 743. Hertz-Picciotto I, Green PG, Delwiche L, Hansen R, Walker C, Pessah IN. Blood Mercury Concentrations in CHARGE Study Children with and without Autism. Environ Health Perspect 2010; 118(1): 161-166. 744. Ip P, Wong V, Ho M, Lee J, Wong W. Mercury exposure in children with autistic spectrum disorder: case-control study. J Child Neurol 2004; 19(6): 431-434. 745. Lewandowski TA. Questions regarding environmental mercury release, special education rates, and autism disorder: an ecological study of Texas by Palmer et al. Health Place 2006; 12(4): 749-750; discussion 751-742. 746. Lewandowski TA, Bartell SM, Yager JW, Levin L. An evaluation of surrogate chemical exposure measures and autism prevalence in Texas. J Toxicol Environ Health A 2009; 72(24): 1592-1603. 747. Ng DK, Chan CH, Soo MT, Lee RS. Low-level chronic mercury exposure in children and adolescents: meta-analysis. Pediatr Int 2007; 49(1): 80-87. 748. Schechter R, Grether JK. Continuing increases in autism reported to California's developmental services system: mercury in retrograde. Arch Gen Psychiatry 2008; 65(1): 19-24. 749. Shearer TR, Larson K, Neuschwander J, Gedney B. Minerals in the hair and nutrient intake of autistic children. J Autism Dev Disord 1982; 12(1): 25-34. 750. Soden SE, Lowry JA, Garrison CB, Wasserman GS. 24-hour provoked urine excretion test for heavy metals in children with autism and typically developing controls, a pilot study. Clin Toxicol (Phila) 2007; 45(5): 476-481. 751. Stamova B, Green PG, Tian Y, Hertz-Picciotto I, Pessah IN, Hansen R et al. Correlations Between Gene Expression and Mercury Levels in Blood of Boys With and Without Autism. Neurotox Res 2009. 63 752. Woods JS, Armel SE, Fulton DI, Allen J, Wessels K, Simmonds PL et al. Urinary Porphyrin Excretion in Neurotypical and Autistic Children. Environ Health Perspect 2010. 753. Zhang X, Lv CC, Tian J, Miao RJ, Xi W, Hertz-Picciotto I et al. Prenatal and perinatal risk factors for autism in China. J Autism Dev Disord 2010; 40(11): 1311-1321. 754. Waring RH, Klovrza LV. Sulphur metabolism in autism. J Nutritional Environmental Medicine 2000; 10(1): 25-32. 755. Shaw W. Increased urinary excretion of a 3-(3-hydroxyphenyl)-3-hydroxypropionic acid (HPHPA), an abnormal phenylalanine metabolite of Clostridia spp. in the gastrointestinal tract, in urine samples from patients with autism and schizophrenia. Nutr Neurosci 2010; 13(3): 135-143. 756. Lidsky TI, Schneider JS. Autism and autistic symptoms associated with childhood lead poisoning. J Applied Research 2005; 5(1): 80-87. 757. Kim SM, Han DH, Lyoo HS, Min KJ, Kim KH, Renshaw P. Exposure to environmental toxins in mothers of children with autism spectrum disorder. Psychiatry Investig 2010; 7(2): 122-127. 758. El-baz F, Elhossiny RM, Elsayed AB, Gaber GM. Hair mercury measurement in Egyptian autistic children. Egyptian Journal of Medical Human Genetics 2010; 11(2): 135-141. 759. Edelson SB, Cantor DS. The neurotoxic etiology of the autistic spectrum disorders: a replication study. Toxicol Ind Health 2000; 16(6): 239-247. 760. Alberti A, Pirrone P, Elia M, Waring RH, Romano C. Sulphation deficit in "lowfunctioning" autistic children: a pilot study. Biol Psychiatry 1999; 46(3): 420-424. 761. Al-Ayadhi LY. Heavy metals and trace elements in hair samples of autistic children in central Saudi Arabia. Neurosciences 2005; 10(3): 213-218. 762. Adams JB, Romdalvik J, Levine KE, Hu L-W. Mercury in first-cut baby hair of children with autism versus typically-developing children. Toxicological and Environmental Chemistry 2008: 1-14. 763. Accardo P, Whitman B, Caul J, Rolfe U. Autism and plumbism. A possible association. Clin Pediatr (Phila) 1988; 27(1): 41-44. 764. Adams JB, Romdalvik J, Ramanujam VM, Legator MS. Mercury, lead, and zinc in baby teeth of children with autism versus controls. J Toxicol Environ Health A 2007; 70(12): 1046-1051. 64 765. Austin DW, Shandley K. An investigation of porphyrinuria in Australian children with autism. J Toxicol Environ Health A 2008; 71(20): 1349-1351. 766. Brasic JR, Barnett JY. Hyperkinesias in a prepubertal boy with autistic disorder treated with haloperidol and valproic acid. Psychol Rep 1997; 80(1): 163-170. 767. Cohen DJ, Johnson WT, Caparulo BK. Pica and elevated blood lead level in autistic and atypical children. Am J Dis Child 1976; 130(1): 47-48. 768. Cohen DJ, Paul R, Anderson GM, Harcherik DF. Blood lead in autistic children. Lancet 1982; 2(8289): 94-95. 769. D'Amelio M, Ricci I, Sacco R, Liu X, D'Agruma L, Muscarella LA et al. Paraoxonase gene variants are associated with autism in North America, but not in Italy: possible regional specificity in gene-environment interactions. Mol Psychiatry 2005; 10(11): 1006-1016. 770. DeSoto MC. Ockham's Razor and autism: the case for developmental neurotoxins contributing to a disease of neurodevelopment. Neurotoxicology 2009; 30(3): 331-337. 771. Desoto MC, Hitlan RT. Blood levels of mercury are related to diagnosis of autism: a reanalysis of an important data set. J Child Neurol 2007; 22(11): 1308-1311. 772. Edelson SB, Cantor DS. Autism: xenobiotic influences. Toxicol Ind Health 1998; 14(4): 553-563. 773. Eppright TD, Sanfacon JA, Horwitz EA. Attention deficit hyperactivity disorder, infantile autism, and elevated blood-lead: a possible relationship. Mo Med 1996; 93(3): 136-138. 774. Eskenazi B, Huen K, Marks A, Harley KG, Bradman A, Barr DB et al. PON1 and neurodevelopment in children from the CHAMACOS study exposed to organophosphate pesticides in utero. Environ Health Perspect 2010; 118(12): 1775-1781. 775. Eskenazi B, Marks AR, Bradman A, Harley K, Barr DB, Johnson C et al. Organophosphate pesticide exposure and neurodevelopment in young Mexican-American children. Environ Health Perspect 2007; 115(5): 792-798. 776. Faber S, Zinn GM, Kern JC, 2nd, Kingston HM. The plasma zinc/serum copper ratio as a biomarker in children with autism spectrum disorders. Biomarkers 2009; 14(3): 171-180. 777. Fido A, Al-Saad S. Toxic trace elements in the hair of children with autism. Autism 2005; 9(3): 290-298. 65 778. Geier DA, Audhya T, Kern JK, Geier MR. Blood mercury levels in autism spectrum disorder: is there a threshold level? Acta Neurobiol Exp (Wars) 2010; 70(2): 177-186. 779. Geier DA, Geier MR. A prospective assessment of porphyrins in autistic disorders: a potential marker for heavy metal exposure. Neurotox Res 2006; 10(1): 57-64. 780. Geier DA, Geier MR. A prospective study of mercury toxicity biomarkers in autistic spectrum disorders. J Toxicol Environ Health A 2007; 70(20): 1723-1730. 781. Geier DA, Geier MR. A case series of children with apparent mercury toxic encephalopathies manifesting with clinical symptoms of regressive autistic disorders. J Toxicol Environ Health A 2007; 70(10): 837-851. 782. Geier DA, Kern JK, Geier MR. A prospective blinded evaluation of urinary porphyrins verses the clinical severity of autism spectrum disorders. J Toxicol Environ Health A 2009; 72(24): 1585-1591. 783. Geier DA, Kern JK, Geier MR. A prospective study of prenatal mercury exposure from maternal dental amalgams and autism severity. Acta Neurobiol Exp (Wars) 2009; 69(2): 189-197. 784. George M, Heeney MM, Woolf AD. Encephalopathy from lead poisoning masquerading as a flu-like syndrome in an autistic child. Pediatr Emerg Care 2010; 26(5): 370-373. 785. Hallaway N. From autistic to lead toxic. Can Nurse 1993; 89(10): 53-54. 786. Holmes AS, Blaxill MF, Haley BE. Reduced levels of mercury in first baby haircuts of autistic children. Int J Toxicol 2003; 22(4): 277-285. 787. Kalkbrenner AE, Daniels JL, Chen JC, Poole C, Emch M, Morrissey J. Perinatal Exposure to Hazardous Air Pollutants and Autism Spectrum Disorders at Age 8. Epidemiology 2010. 788. Kern JK, Geier DA, Adams JB, Geier MR. A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder. Biometals 2010. 789. Kern JK, Geier DA, Adams JB, Mehta JA, Grannemann BD, Geier MR. Toxicity Biomarkers in Autism Spectrum Disorder: A Blinded Study of Urinary Porphyrins. Pediatr Int 2010. 790. Kern JK, Grannemann BD, Trivedi MH, Adams JB. Sulfhydryl-reactive metals in autism. J Toxicol Environ Health A 2007; 70(8): 715-721. 66 791. Lakshmi Priya MD, Geetha A. Level of Trace Elements (Copper, Zinc, Magnesium and Selenium) and Toxic Elements (Lead and Mercury) in the Hair and Nail of Children with Autism. Biol Trace Elem Res 2010. 792. Larsson M, Weiss B, Janson S, Sundell J, Bornehag CG. Associations between indoor environmental factors and parental-reported autistic spectrum disorders in children 6-8 years of age. Neurotoxicology 2009. 793. Majewska MD, Urbanowicz E, Rok-Bujko P, Namyslowska I, Mierzejewski P. Agedependent lower or higher levels of hair mercury in autistic children than in healthy controls. Acta Neurobiol Exp (Wars) 2010; 70(2): 196-208. 794. Newton KE, Leonard M, Delves HT, Bowen-Jones D. A problem with her lead weight. Ann Clin Biochem 2005; 42(Pt 2): 145-148. 795. Palmer RF, Blanchard S, Stein Z, Mandell D, Miller C. Environmental mercury release, special education rates, and autism disorder: an ecological study of Texas. Health Place 2006; 12(2): 203-209. 796. Palmer RF, Blanchard S, Wood R. Proximity to point sources of environmental mercury release as a predictor of autism prevalence. Health Place 2009; 15(1): 18-24. 797. Rauh VA, Garfinkel R, Perera FP, Andrews HF, Hoepner L, Barr DB et al. Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children. Pediatrics 2006; 118(6): e1845-1859. 798. Roberts EM, English PB, Grether JK, Windham GC, Somberg L, Wolff C. Maternal residence near agricultural pesticide applications and autism spectrum disorders among children in the California Central Valley. Environ Health Perspect 2007; 115(10): 14821489. 799. Shannon M, Woolf A, Goldman R. Children's environmental health: one year in a pediatric environmental health specialty unit. Ambul Pediatr 2003; 3(1): 53-56. 800. Volk HE, Hertz-Picciotto I, Delwiche L, Lurmann F, McConnell R. Residential Proximity to Freeways and Autism in the CHARGE study. Environ Health Perspect 2010. 801. Walker SJ, Segal J, Aschner M. Cultured lymphocytes from autistic children and nonautistic siblings up-regulate heat shock protein RNA in response to thimerosal challenge. Neurotoxicology 2006; 27(5): 685-692. 802. Windham GC, Zhang L, Gunier R, Croen LA, Grether JK. Autism spectrum disorders in relation to distribution of hazardous air pollutants in the San Francisco bay area. Environ Health Perspect 2006; 114(9): 1438-1444. 67 803. Yorbik O, Kurt I, Hasimi A, Ozturk O. Chromium, cadmium, and lead levels in urine of children with autism and typically developing controls. Biol Trace Elem Res 2010; 135(1-3): 10-15. 804. Lonsdale D. Thiamine tetrahydrofurfuryl disulfide: A little known therapeutic agent. Medical Science Monitor 2004; 10(9): RA199-RA203. 805. Ghanizadeh A. Novel Treatment for Lead Exposure in Children with Autism. Biol Trace Elem Res 2010. 806. Kane RC. A possible association between fetal/neonatal exposure to radiofrequency electromagnetic radiation and the increased incidence of autism spectrum disorders (ASD). Med Hypotheses 2004; 62(2): 195-197. 807. Bernard S, Enayati A, Roger H, Binstock T, Redwood L. The role of mercury in the pathogenesis of autism. Mol Psychiatry 2002; 7 Suppl 2: S42-43. 808. Bernard S, Enayati A, Redwood L, Roger H, Binstock T. Autism: a novel form of mercury poisoning. Med Hypotheses 2001; 56(4): 462-471. 809. Wahl RU. Could oxytocin administration during labor contribute to autism and related behavioral disorders?--A look at the literature. Med Hypotheses 2004; 63(3): 456-460. 810. Williams EL, Casanova MF. Potential teratogenic effects of ultrasound on corticogenesis: Implications for autism. Med Hypotheses 2010. 811. Schultz ST. Can autism be triggered by acetaminophen activation of the endocannabinoid system? Acta Neurobiol Exp (Wars) 2010; 70(2): 227-231. 812. Rodier PM, Hyman SL. Early environmental factors in autism. Mental Retard Dev Disabil Res Rev 1998; 4(2): 121-128. 813. Messer A. Mini-review: polybrominated diphenyl ether (PBDE) flame retardants as potential autism risk factors. Physiol Behav 2010; 100(3): 245-249. 814. London EA. The environment as an etiologic factor in autism: a new direction for research. Environ Health Perspect 2000; 108 Suppl 3: 401-404. 815. Herbert MR. Clinical implications of environmental toxicology for children's neurodevelopment in autism. Future Neurology 2007; 2(2): 167-171. 816. Good P. Did acetaminophen provoke the autism epidemic? Altern Med Rev 2009; 14(4): 364-372. 68 817. Dietert RR, Zelikoff JT. Pediatric immune dysfunction and health risks following earlylife immune insult. Current Pediatric Reviews 2009; 5(1): 36-51. 818. Austin D. An epidemiological analysis of the ‘autism as mercury poisoning’ hypothesis. International Journal of Risk and Safety in Medicine 2008; 20(3): 135-142. 819. Blaxill MF. Concerns continue over mercury and autism. Am J Prev Med 2004; 26(1): 91; reply 91-92. 820. Brudnak MA. Probiotics as an adjuvant to detoxification protocols. Med Hypotheses 2002; 58(5): 382-385. 821. Curtis LT, Patel K. Nutritional and environmental approaches to preventing and treating autism and attention deficit hyperactivity disorder (ADHD): a review. J Altern Complement Med 2008; 14(1): 79-85. 822. Desoto MC, Hitlan RT. Sorting out the spinning of autism: heavy metals and the question of incidence. Acta Neurobiol Exp (Wars) 2010; 70(2): 165-176. 823. Desoto MC. A reply to Soden et al.: your data shows autistic children have higher levels of heavy metals. Clin Toxicol (Phila) 2008; 46(10): 1098. 824. Dietert RR, Dietert JM. Possible role for early-life immune insult including developmental immunotoxicity in chronic fatigue syndrome (CFS) or myalgic encephalomyelitis (ME). Toxicology 2008; 247(1): 61-72. 825. Drum DA. Are toxic biometals destroying your children's future? Biometals 2009; 22(5): 697-700. 826. Dufault R, Schnoll R, Lukiw WJ, Leblanc B, Cornett C, Patrick L et al. Mercury exposure, nutritional deficiencies and metabolic disruptions may affect learning in children. Behav Brain Funct 2009; 5(1): 44. 827. Eskenazi B, Rosas LG, Marks AR, Bradman A, Harley K, Holland N et al. Pesticide toxicity and the developing brain. Basic Clin Pharmacol Toxicol 2008; 102(2): 228-236. 828. Geier DA, King PG, Sykes LK, Geier MR. A comprehensive review of mercury provoked autism. Indian J Med Res 2008; 128(4): 383-411. 829. Grandjean P, Landrigan PJ. Developmental neurotoxicity of industrial chemicals. Lancet 2006; 368(9553): 2167-2178. 830. Hyman MH. The impact of mercury on human health and the environment. Altern Ther Health Med 2004; 10(6): 70-75. 69 831. Jurewicz J, Hanke W. Prenatal and childhood exposure to pesticides and neurobehavioral development: review of epidemiological studies. Int J Occup Med Environ Health 2008; 21(2): 121-132. 832. Kalia M. Brain development: anatomy, connectivity, adaptive plasticity, and toxicity. Metabolism 2008; 57 Suppl 2: S2-5. 833. Labie D. [Developmental neurotoxicity of industrial chemicals]. Med Sci (Paris) 2007; 23(10): 868-872. 834. Landrigan PJ. What causes autism? Exploring the environmental contribution. Curr Opin Pediatr 2010. 835. Lloyd-Smith M, Sheffield-Brotherton B. Children's environmental health: intergenerational equity in action--a civil society perspective. Ann N Y Acad Sci 2008; 1140: 190-200. 836. McGinnis WR. Mercury and autistic gut disease. Environ Health Perspect 2001; 109(7): A303-304. 837. McGovern V. Autism and agricultural pesticides. Integrating data to track trends. Environ Health Perspect 2007; 115(10): A504. 838. Mutter J, Naumann J, Schneider R, Walach H, Haley B. Mercury and autism: accelerating evidence? Neuro Endocrinol Lett 2005; 26(5): 439-446. 839. Palomo T, Beninger RJ, Kostrzewa RM, Archer T. Brain sites of movement disorder: genetic and environmental agents in neurodevelopmental perturbations. Neurotox Res 2003; 5(1-2): 1-26. 840. Roman GC. Autism: transient in utero hypothyroxinemia related to maternal flavonoid ingestion during pregnancy and to other environmental antithyroid agents. J Neurol Sci 2007; 262(1-2): 15-26. 841. Rosas LG, Eskenazi B. Pesticides and child neurodevelopment. Curr Opin Pediatr 2008; 20(2): 191-197. 842. Rout UK, Clausen P. Common increase of GATA-3 level in PC-12 cells by three teratogens causing autism spectrum disorders. Neurosci Res 2009; 64(2): 162-169. 843. Sullivan KM. The interaction of agricultural pesticides and marginal iodine nutrition status as a cause of autism spectrum disorders. Environ Health Perspect 2008; 116(4): A155. 70 844. Zhang J, Smith KR. Indoor air pollution: a global health concern. Br Med Bull 2003; 68: 209-225. 845. Silverman JL, Tolu SS, Barkan CL, Crawley JN. Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP. Neuropsychopharmacology 2010; 35(4): 976-989. 846. Schneider T, Turczak J, Przewlocki R. Environmental enrichment reverses behavioral alterations in rats prenatally exposed to valproic acid: issues for a therapeutic approach in autism. Neuropsychopharmacology 2006; 31(1): 36-46. 847. Roullet FI, Wollaston L, deCatanzaro D, Foster JA. Behavioral and molecular changes in the mouse in response to prenatal exposure to the anti-epileptic drug valproic acid. Neuroscience 2010; 170(2): 514-522. 848. Narita M, Oyabu A, Imura Y, Kamada N, Yokoyama T, Tano K et al. Nonexploratory movement and behavioral alterations in a thalidomide or valproic acid-induced autism model rat. Neuroscience Research 2010; 66(1): 2-6. 849. Kenet T, Froemke RC, Schreiner CE, Pessah IN, Merzenich MM. Perinatal exposure to a noncoplanar polychlorinated biphenyl alters tonotopy, receptive fields, and plasticity in rat primary auditory cortex. Proc Natl Acad Sci U S A 2007; 104(18): 7646-7651. 850. Fatemi SH, Folsom TD, Reutiman TJ, Huang H, Oishi K, Mori S. Prenatal viral infection of mice at E16 causes changes in gene expression in hippocampi of the offspring. European Neuropsychopharmacology 2009; 19(9): 648-653. 851. Fatemi SH, Earle J, Kanodia R, Kist D, Emamian ES, Patterson PH et al. Prenatal viral infection leads to pyramidal cell atrophy and macrocephaly in adulthood: implications for genesis of autism and schizophrenia. Cell Mol Neurobiol 2002; 22(1): 25-33. 852. Sheng L, Ding X, Ferguson M, McCallister M, Rhoades R, Maguire M et al. Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and downregulation of receptor tyrosine kinase, MET. Toxicol Sci 2010; 118(2): 625-634. 853. Patterson PH. Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness. Curr Opin Neurobiol 2002; 12(1): 115-118. 854. Berman RF, Pessah IN, Mouton PR, Mav D, Harry J. Low-Level Neonatal Thimerosal Exposure: Further Evaluation of Altered Neurotoxic Potential in SJL Mice. Toxicol Sci 2008; 101(2): 294-309. 855. Curtis JT, Hood AN, Chen Y, Cobb GP, Wallace DR. Chronic metals ingestion by prairie voles produces sex-specific deficits in social behavior: an animal model of autism. Behav Brain Res 2010; 213(1): 42-49. 71 856. Jolous-Jamshidi B, Cromwell HC, McFarland AM, Meserve LA. Perinatal exposure to polychlorinated biphenyls alters social behaviors in rats. Toxicol Lett 2010. 857. Kimura-Kuroda J, Nagata I, Kuroda Y. Disrupting effects of hydroxy-polychlorinated biphenyl (PCB) congeners on neuronal development of cerebellar Purkinje cells: a possible causal factor for developmental brain disorders? Chemosphere 2007; 67(9): S412-420. 858. Kuwagata M, Ogawa T, Shioda S, Nagata T. Observation of fetal brain in a rat valproateinduced autism model: a developmental neurotoxicity study. Int J Dev Neurosci 2009; 27(4): 399-405. 859. Laviola G, Adriani W, Gaudino C, Marino R, Keller F. Paradoxical effects of prenatal acetylcholinesterase blockade on neuro-behavioral development and drug-induced stereotypies in reeler mutant mice. Psychopharmacology (Berl) 2006; 187(3): 331-344. 860. Levin ED, Chrysanthis E, Yacisin K, Linney E. Chlorpyrifos exposure of developing zebrafish: effects on survival and long-term effects on response latency and spatial discrimination. Neurotoxicol Teratol 2003; 25(1): 51-57. 861. Minami T, Miyata E, Sakamoto Y, Yamazaki H, Ichida S. Induction of metallothionein in mouse cerebellum and cerebrum with low-dose thimerosal injection. Cell Biol Toxicol 2010; 26(2): 143-152. 862. Montgomery KS, Mackey J, Thuett K, Ginestra S, Bizon JL, Abbott LC. Chronic, lowdose prenatal exposure to methylmercury impairs motor and mnemonic function in adult C57/B6 mice. Behav Brain Res 2008; 191(1): 55-61. 863. Bradstreet JJ, Geier DA, Kartzinel JJ, Adams JB, Geier MR. A case-control study of mercury burden in children with autistic spectrum disorders. J Amer Physicians Surg 2003; 8(3): 76-79. 864. Shannon M, Graef JW. Lead intoxication in children with pervasive developmental disorders. J Toxicol Clin Toxicol 1996; 34(2): 177-181. 865. Nataf R, Skorupka C, Amet L, Lam A, Springbett A, Lathe R. Porphyrinuria in childhood autistic disorder: implications for environmental toxicity. Toxicol Appl Pharmacol 2006; 214(2): 99-108. 866. Geier DA, Geier MR. A clinical trial of combined anti-androgen and anti-heavy metal therapy in autistic disorders. Neuro Endocrinol Lett 2006; 27(6): 833-838. 72 867. Lonsdale D, Shamberger RJ, Audhya T. Treatment of autism spectrum children with thiamine tetrahydrofurfuryl disulfide: a pilot study. Neuro Endocrinol Lett 2002; 23(4): 303-308. 868. Patel K, Curtis LT. A comprehensive approach to treating autism and attention-deficit hyperactivity disorder: a prepilot study. J Altern Complement Med 2007; 13(10): 10911097. 869. Gorski D. Mercury in vaccines as a cause of autism and Autism Spectrum Disorders (ASDs): A failed hypothesis. Scientific Review of Alternative Medicine 2007; 11: 23-28. 870. Fombonne E. Thimerosal disappears but autism remains. Arch Gen Psychiatry 2008; 65(1): 15-16. 871. DeStefano F. Thimerosal-containing vaccines: evidence versus public apprehension. Expert Opin Drug Saf 2009; 8(1): 1-4. 872. Thimerosal: updated statement. An Advisory Committee Statement (ACS). Can Commun Dis Rep 2007; 33(ACS-6): 1-13. 873. Andrews N, Miller E, Grant A, Stowe J, Osborne V, Taylor B. Thimerosal exposure in infants and developmental disorders: a retrospective cohort study in the United kingdom does not support a causal association. Pediatrics 2004; 114(3): 584-591. 874. Aschner M, Ceccatelli S. Are neuropathological conditions relevant to ethylmercury exposure? Neurotox Res 2010; 18(1): 59-68. 875. Baker JP. Mercury, vaccines, and autism: one controversy, three histories. Am J Public Health 2008; 98(2): 244-253. 876. Bigham M, Copes R, Srour L. Exposure to thimerosal in vaccines used in Canadian infant immunization programs, with respect to risk of neurodevelopmental disorders. Can Commun Dis Rep 2002; 28(9): 69-80. 877. Chatterjee A, O'Keefe C. Current controversies in the USA regarding vaccine safety. Expert Rev Vaccines 2010; 9(5): 497-502. 878. Clements CJ, McIntyre PB. When science is not enough - a risk/benefit profile of thiomersal-containing vaccines. Expert Opin Drug Saf 2006; 5(1): 17-29. 879. Clifton JC, 2nd. Mercury exposure and public health. Pediatr Clin North Am 2007; 54(2): 237-269, viii. 73 880. Fombonne E, Zakarian R, Bennett A, Meng L, McLean-Heywood D. Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations. Pediatrics 2006; 118(1): e139-150. 881. Hessel L. [Mercury in vaccines]. Bull Acad Natl Med 2003; 187(8): 1501-1510. 882. Hviid A, Stellfeld M, Wohlfahrt J, Melbye M. Association between thimerosalcontaining vaccine and autism. JAMA 2003; 290(13): 1763-1766. 883. MacIntyre CR, Leask J. Immunization myths and realities: responding to arguments against immunization. J Paediatr Child Health 2003; 39(7): 487-491. 884. Madi A. Being on the track of thimerosal. Review. Acta Microbiol Immunol Hung 2005; 52(1): 95-103. 885. Madsen KM, Lauritsen MB, Pedersen CB, Thorsen P, Plesner AM, Andersen PH et al. Thimerosal and the occurrence of autism: negative ecological evidence from Danish population-based data. Pediatrics 2003; 112(3 Pt 1): 604-606. 886. Meadows M. IOM report: no link between vaccines and autism. FDA Consum 2004; 38(5): 18-19. 887. Miles JH, Takahashi TN. Lack of association between Rh status, Rh immune globulin in pregnancy and autism. Am J Med Genet A 2007; 143(13): 1397-1407. 888. Munoz MA, Abarca VK, Jimenez de la JJ, Luchslnger FV, O'Ryan GM, Ripoll ME et al. [Safety of thimerosal containing vaccines. Statement of the Consultive Committee of Immunizations on behalf of the Chilean Infectious Diseases Society]. Rev Chilena Infectol 2007; 24(5): 372-376. 889. Price CS, Thompson WW, Goodson B, Weintraub ES, Croen LA, Hinrichsen VL et al. Prenatal and Infant Exposure to Thimerosal From Vaccines and Immunoglobulins and Risk of Autism. Pediatrics 2010. 890. Scahill L, Bearss K. The rise in autism and the mercury myth. J Child Adolesc Psychiatr Nurs 2009; 22(1): 51-53. 891. Schultz ST. Does thimerosal or other mercury exposure increase the risk for autism? A review of current literature. Acta Neurobiol Exp (Wars) 2010; 70(2): 187-195. 892. Silbergeld EK. Mercury, vaccines, and autism, revisited. Am J Public Health 2008; 98(8): 1350; author reply 1350-1351. 893. Singh VK. Thimerosal is unrelated to autoimmune autism. Pediatr Allergy Immunol 2007; 18(1): 89. 74 894. Stehr-Green P, Tull P, Stellfeld M, Mortenson PB, Simpson D. Autism and thimerosalcontaining vaccines: lack of consistent evidence for an association. Am J Prev Med 2003; 25(2): 101-106. 895. Thompson WW, Price C, Goodson B, Shay DK, Benson P, Hinrichsen VL et al. Early thimerosal exposure and neuropsychological outcomes at 7 to 10 years. N Engl J Med 2007; 357(13): 1281-1292. 896. Verstraeten T, Davis RL, DeStefano F, Lieu TA, Rhodes PH, Black SB et al. Safety of thimerosal-containing vaccines: a two-phased study of computerized health maintenance organization databases. Pediatrics 2003; 112(5): 1039-1048. 897. Weisser K, Bauer K, Volkers P, Keller-Stanislawski B. [Thiomersal and immunisations]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2004; 47(12): 11651174. 898. Geier MR, Geier DA. Neurodevelopmental disorders after thimerosal-containing vaccines: a brief communication. Exp Biol Med (Maywood) 2003; 228(6): 660-664. 899. Geier DA, Geier MR. An assessment of downward trends in neurodevelopmental disorders in the United States following removal of Thimerosal from childhood vaccines. Med Sci Monit 2006; 12(6): CR231-239. 900. Geier D, Geier MR. Neurodevelopmental disorders following thimerosal-containing childhood immunizations: a follow-up analysis. Int J Toxicol 2004; 23(6): 369-376. 901. Blaxill MF, Redwood L, Bernard S. Thimerosal and autism? A plausible hypothesis that should not be dismissed. Med Hypotheses 2004; 62(5): 788-794. 902. Geier DA, Geier MR. An assessment of the impact of thimerosal on childhood neurodevelopmental disorders. Pediatr Rehabil 2003; 6(2): 97-102. 903. Geier DA, Geier MR. A two-phased population epidemiological study of the safety of thimerosal-containing vaccines: a follow-up analysis. Med Sci Monit 2005; 11(4): CR160-170. 904. Geier DA, Geier MR. A meta-analysis epidemiological assessment of neurodevelopmental disorders following vaccines administered from 1994 through 2000 in the United States. Neuro Endocrinol Lett 2006; 27(4): 401-413. 905. Geier DA, Geier MR. An evaluation of the effects of thimerosal on neurodevelopmental disorders reported following DTP and Hib vaccines in comparison to DTPH vaccine in the United States. J Toxicol Environ Health A 2006; 69(15): 1481-1495. 75 906. Young HA, Geier DA, Geier MR. Thimerosal exposure in infants and neurodevelopmental disorders: An assessment of computerized medical records in the Vaccine Safety Datalink. J Neurol Sci 2008; 271(1-2): 110-118. 76