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Research Scientist
Member Number: 23026214
Rockville, MD 20850
Portfolio: http://www.beyond.com/people/23026214
Professional Information
Job Function: Research, Science & Biotech, Media & Communication
Education: Post Graduate Degree
Experience: 5 – 10 Years
Employment: Full-Time, W-2 Contractor, 1099 Contractor
Salary: $70-100k
Security Clearance: Active Confidential
Citizenship: U.S. Citizen
Resume
*** M. ***, PhD
RESEARCH SCIENTIST / SCIENCE WRITER
Skilled scientific researcher, published writer, and team leader with an interdisciplinary PhD in biology and expertise
spanning physiology, biochemistry, molecular biology, cellular biology, and immunology. Adept at communicating and
publishing complex scientific research results in peer-reviewed journal articles, literature review articles, and science
writing for lay audiences. Advanced knowledge of the immunologic mechanisms of liver injury and repair, focusing on the
interactions of the innate immunity, cytokines, and hepatic cells in alcoholic and nonalcoholic fatty liver, liver inflammation,
and liver injury. Research experience spans both university and federal government laboratory environments. Core
competencies include:
Scientific Knowledge: Well established analytical approach to investigating scientific questions, Experienced in knowledge
acquisition and interpretation and analysis of data
Research Skill Development: Research techniques and laboratory safety, Experimental design, Data analysis and
interpretation, Statistical analysis, Critical review and evaluation of scientific literature
Communication Skills: Writing : Peer-reviewed/refereed articles, Literature review articles, Science writing for lay public,
Speaking : Teaching, Presentation of research (Posters, Conferences/seminars, PowerPoint presentations)
Leadership skills: Creating a vision and setting goals, Delegating responsibilities, Motivating/inspiring others,
Mentoring/serving as a role model, Diversity
Professionalism: Workplace, Institutional, Collegial, and Universal
Research Scientist
Responsible Conduct of Research Skills : Data ownership and sharing, Publication practices and responsible authorship,
Research involving animals
RESEARCH EXPERIENCE
National Institutes of Health / National Institute on Alcohol Abuse and Alcoholism / Laboratory of Liver Diseases :
Rockville, Maryland December *** - Present
Postdoctoral Fellow
Conducting wide-ranging experiments with animal models of both alcoholic liver disease and non-alcoholic, obesity
related liver disease to advance knowledge of the interaction of the innate immune system, cytokines, and hepatic cells in
liver diseases. Employing a variety of laboratory techniques and assays at the gene, protein, and cellular levels, including
animal models, transgenic mice, and in vitro and in vivo studies as well as procedures in murine models, including insulin
sensitivity, glucose tolerance, and oral gavage.
Recognized for outstanding performance and outcomes with selection for an oral presentation at the *** International
Symposium on Cells of the Hepatic Sinusoid.
Presented at several conferences and meetings with solid publishing record (complete listing below)
Made critical discovery demonstrating IL*** deficient mice are resistant to ethanol and high fat induced steatosis but more
susceptible to hepatic inflammation
Determined novel anti-inflammatory and anti-apoptotic roles of sinusoidal endothelial cell-specific-signal transducer and
activator of transcription 3 in alcoholic liver injury
Mentored students in execution of their project and instructed them how to analyze and present results.
Fully trained and certified in all Department of Health & Human Services safety and security guidelines, including animal
safety / handling and techniques for animal models of disease
University of North Carolina at Charlotte / Department of Biology
Charlotte, NC US
August *** - December ***
Graduate Research Assistantship & Teaching Assistantship
While in pursuit of a PhD, served as a core scientific contributor to the exploration into the underlying mechanisms in the
cross talk and signaling pathways of Endothelin***, a potent vasoconstrictor, and production of Thromboxane A2, an
Arachidonic Acid derived eicosanoid, in Kupffer Cells, the resident macrophages in the liver, during the early development
of fibrosis and associated portal hypertension, with or without the sequential stress of acute endotoxemia.
Research Scientist
Uncovered the hepatic stress associated with the development of portal hypertension induces significant modifications in
the receptor and intermediates of endothelin*** signaling in Kupffer cells, specifically a shift from Gq induced signaling to
Gi induced signaling in the activation of cPLA2 and production of Thromboxane A***
Supervised and mentored an undergraduate in his honors research project and associated experiments, including survival
surgeries in rodent model of fibrosis, to the achievement of 1st place for the universitys Department of Biology annual
undergraduate research competition.
Simultaneously taught laboratory classes and proctored exams in support of professor lectures on subjects including plant
biology, introductory biology, anatomy, and physiology.
Developed a reputation for effectively communicating complex biological phenomena to first-year undergraduates.
EDUCATION
University of North Carolina at Charlotte, Charlotte NC : PhD in Biology (***)
Dissertation: Endothelin*** Induced Activation of Cytosolic Phospholipase A2 and Thromboxane A2 production in
sequential hepatic stresses: Potential Role in Portal Hypertension
Ph.D Candidacy Examination: NIH R*** Grant Proposal and Defense - Annexin*** and CD4+ T regulatory cells: Mediation
by IL*** and Role in Inflammatory Bowel Disease
GPA : *** out of ***
University of South Carolina, Columbia SC / Bachelor of Science in Biology (***)
Magna Cum Laude / GPA : *** out of ***
ACADEMIC AWARDS, HONORS, ACCOMPLISHMENTS
Golden Key National Honor Society
Alpha Lambda Delta National Honor Society National Society of Collegiate Scholars
Kappa Sigma Fraternity Outstanding Scholar Award
Phi Beta Kappa National Honor Society
Biology Teaching Assistantship
Biology Research Assistantship
Association of Biology Graduate Students
AFFILIATIONS
International Society for Hepatic Sinusoidal Research
Research Scientist
American Association for the Advancement of Science
D.C. Science Writers Association
ABSTRACTS AND PRESENTATIONS
INVITED TALKS
*** M ***, Hua Wang, Oygi Park, Sung Hwan Ki, Shi Yin, Fouad Lafdil, Bin Gao. Dissociation Between Steatosis and
Inflammation in Alcoholic and Nonalcoholic Fatty Liver in IL***deficient Mice: Protective Role of IL***/STAT3 ISHSR.
August ***
B. Gao, A. ***, S.H. Ki, O. Park. Molecular Mechanisms of Alcoholic Liver Disease: Roles of Cytokines ISBRA. September
***
POSTERS
Won-il Jeong, Ogyi Park, Yang-Gun Suh, Jin-Seok Byun, So-Young Park, Ja-Kyung Kim, Hyojin Ko, Hua Wang, *** M ***,
Bin Gao. Suppression of Innate Immunity (NK cell/IFN-g) in the Advanced Stages of Liver Fibrosis in Mice AASLD.
November ***
*** M ***, Ogyi Park, Hua Wang, Akira Moh, Xin Yuan Fu, Bin Gao Anti-inflammatory and Anti-apoptotic roles of
Endothelial Cell STAT3 in Alcoholic Liver Injury RSA. June ***
Norio Horiguchi, Lafdil Fouad, *** M ***, Ogyi Park, Hua Wang, Rajesh Mohanraj, Partha Mukhopadhyay, Xin Yuan Fu,
Pal Pacher, Bin Gao. Dissociation of Liver Inflammation and Hepatocellular Damage Induced by Carbon Tetrachloride in
Myeloid Cell-specific STAT3 Knockout Mice AASLD. November ***
*** M ***, Jian X Zhang. Altered Endothelin*** Signaling in the Activation of Cytosolic Phospholipase A2 (cPLA2) and
Thromboxane A2 (TXA2) Productions in Kupffer Cells (KC) of the Prefibrotic Rat Liver: A Possible Mechanism in the Early
Development of Portal Hypertension in Cirrhosis Experimental Biology. April ***
*** ***, Mina Masrorpour, Jian X Zhang. LPS Enhances Endothelin*** Induced Activation of Cytosolic Phosoholipase A2
And Thromboxane A2 Production from Kupffer Cells of the Prefibrotic Rat Liver Experimental Biology. April ***
*** ***, Mina Masrorpour, Amel Karaa, Hongzhi Xu, and Jian X. Zhang. Endothelin*** Induced Release of Thromboxane
A2 from Kupffer Cells in the Prefibrotic Rat Liver: Potential Role in the Development of Portal Hypertension Experimental
Biology. April *** - #***
Kara King, *** ***, Rafael Sanchez, Walid S. Kamoun, Mark G. Clemens, Laura W. Schrum, Jian Zhang. Caloric
Restriction Inhibits Hyperlipedemia-Induced Liver Damage in Aging Mice Experimental Biology. April *** - #***
PUBLICATIONS - PEER-REVIEWED ARTICLES AND LITERATURE REVIEWS
Research Scientist
*** M. ***, Mina Masrorpour, Christian Klaus, Jian X. Zhang. LPS Exacerbates Endothelin*** Induced Activation of
Cytosolic Phosoholipase A2 and Thromboxane A2 Production from Kupffer Cells of the Prefibrotic Rat Liver Journal of
Hepatology. February ***, ***:*** ***
*** M. ***, Jian X Zhang. Altered Endothelin*** Signaling in Production of Thromboxane A2 in Kupffer Cells from Bile Duct
Ligated Rats Cellular and Molecular Immunology, December ***, 6:***
*** M. ***, Hua Wang, Ogyi Park, Norio Horiguchi, Fouad Lafdil, Partha Mukhopadhyay, Akira Moh, Xin Yuan Fu, George
Kunos, Pal Pacher, Bin Gao. Anti-inflammatory and Anti-apoptotic roles of Endothelial Cell STAT3 in Alcoholic Liver Injury
Alcoholism: Clinical and Experimental Research, April ***, ***(4):***
Norio Horiguchi, Fouad Lafdil, *** M ***, Ogyi Park, Hua Wang, Rajesh Mohanraj, Partha Mukhopadhyay, Xin Yuan Fu,
Pal Pacher, Bin Gao. Dissociation of Liver Inflammation and Hepatocellular Damage Induced by Carbon Tetrachloride in
Myeloid Cell-specific STAT3 Knockout Mice Hepatology, May ***, ***(5):***
Fouad Lafdil, *** M. ***, Sung-Hwan Ki, Bin Gao. Th*** Cells and Their Associated Cytokines in Liver Diseases Cellular
and Molecular Immunology, July ***, 7(4):***
*** M. ***, Norio Horiguchi, Svetlana Radaeva, Won-IL Jeong Bin Gao. Molecular Mechanisms of Alcoholic Liver Disease:
Innate immunity and cytokines Alcoholism: Clinical and Experimental Research, in press.(Review Article)
Won-il Jeong, Ogyi Park, Yang-Gun Suh, Jin-Seok Byun, So-Young Park, Ja-Kyung Kim, Hyojin Ko, Hua Wang, *** M.
***, Bin Gao. Suppression of Innate Immunity (Natural Killer Cell/Interferon-g) in the Advanced Stages of Liver Fibrosis in
Mice Hepatology. (revision under review).
*** M. ***, Hua Wang, Ogyi Park, Sung-Hwan Ki, Fouad Lafdil, Shi Yin, Bin Gao. Dissociation Between Steatosis and
Inflammation in Alcoholic and Non-alcoholic Fatty Liver in IL***deficient Mice: Protective Role of IL***/STAT3(in
preparation for submission).
PUBLICATIONS - SCIENCE WRITING
*** M. ***. How Dengue Virus Affects Cells National Institutes of Health Research Matters. October ***, *** *** M. ***. Lead
Poisoning Treatment Less Effective for Mercury National Institutes of Health Research Matters. November 8, ***