Basic Human Genetics course
‘Genetics for dummies’
18 & 19 October 2012
vs 121017
This 2-day course will explain to you the basic concepts in human genetics,
and more in particular “Complex Genetics”. This is the scientific discipline that
studies the role of genetic variation in common complex diseases (such as
osteoporosis, cardiovascular disease, diabetes, etc.) and traits (such as blood
pressure, BMD, glucose level, height, cholesterol level, etc.).
Fuelled by successful applications of Genome Wide Association Studies (GWAS)
and High Throughput (HT) Sequencing in various disease areas, this course is
meant to give some introductory background for people wanting to start or
become involved in such studies, or just want to know what it is all about. Mostly,
these will be people who are specialized in the diseases and/or traits of interest,
but do not have the necessary genetic background knowledge.
Target audience
The target audience includes -but is not limited to- Master of Science students,
technicians, PhD students, post-docs, assistant/associate/full professors with an
interest in genetic studies. These may come from various disciplines and from a
clinical, basic/biological, epidemiological or public health background.
Students who have followed the Nihes Summer Course (master Health Science
and related courses) ESP57 (“Genomics in Molecular Medicine”) do not have to
follow this course because the contents are similar. The course is compulsory
for Research master students I&I.
This short course is also very useful as an introduction to the more advanced
MolMed “SNP course” that starts this year on November 19th, and which covers
a much wider and deeper range of topics in this rapidly evolving field (see:
www.molmed.nl/courses).
The total number of participants is limited to 75.
Course fees
The attendance fee of the course is €350, but certain participants can get a
discount. See below for all details.
1
Program
In “Genetics for Dummies” five experienced lecturers from Erasmus MC will
introduce you to basic concepts in complex genetics, laboratory techniques, and
statistical analytical issues. The program is built on four half days, each of which
is covered by one speaker. After every talk, much time is reserved for Questions
and Answers, to get interactivity with the participants.
Basic knowledge, background literature
Basic knowledge of (molecular) biology is expected from the participants.
Background literature on the topic can be found in :
- “Genetics for Dummies” (2nd edition, T.R. Robinson, Wiley Publishing, Inc.;
ISBN 978-0-470-55174-5)
- "Molecular Biology of the Cell" (5th ed.; editors: Alberts et al.; published by
Garland Sciences; ISBN 978-0-8153-4111-6 );
- "Human Molecular Genetics" (4th ed.; editors Tom Strachan& Andrew Reed.
ISBN 0-471-33061-2; published by Garland Sciences; £40,-).
To this aim, also a series of basic papers is published on our website:
www.molmed.nl on the page of the SNP course. At the start of the course a
reader will be issued.
Course organizers
Dr. Robert Kraaij, Dept Internal Medicine, Erasmus MC
Dr. Joyce van Meurs, Dept Internal Medicine, Erasmus MC
Dr. Fernando Rivadeneira, Dept Internal Medicine, Erasmus MC
Prof. Dr André Uitterlinden, Dept Internal Medicine, Erasmus MC
Dr. Annemieke Verkerk, Dept Internal Medicine, Erasmus MC
Dr. Frank van Vliet, Postgraduate School MolMed
Lecturers
Prof.dr. André Uitterlinden, Dr. Annemieke Verkerk, Dr. Joyce van Meurs, Dr.
Robert Kraaij, and Dr. Fernando Rivadeneira.
Subscription is open now on: www.molmed.nl. If you have any questions, please
mail or call Joris Lenstra or Frank van Vliet: molmed@erasmusmc.nl (010-70 38 053 or
06-5474 6408).
First Day, Thursday 18 October, Room Ae 4.06
Moderator: André Uitterlinden
Time
Speaker
09.00-09.30
Registration and coffee
09.30-10.30
Annemieke Verkerk
10.30-10.45
Coffee break
10.45-11.45
André Uitterlinden
11.45-12.00
Coffee break
12.00-12.45
André Uitterlinden
12.45-13.30
Lunch
13.30-14.30
Joyce van Meurs
14.30-14.45
Coffee break
14.45-15.45
Joyce van Meurs
Subject
Basic genetics: history & concepts
Introduction to complex genetics (1)
Introduction to complex genetics (2)
Laboratory techniques in basic genetics
Laboratory techniques in complex
genetics
2
Second Day, Friday 19 October, Room Ae 4.06
Moderator: André Uitterlinden
Time
Speaker
10.15-11.15
Fernando Rivadeneira
11.15-11.30
11.30-12.30
Coffee break
Fernando Rivadeneira
12.30-13.15
13.15-14.15
Lunch
Robert Kraaij
14.15-14.30
14.30-15.30
Coffee break
Robert Kraaij
15.30-15.45
15.45-16.45
Coffee break
Annemieke Verkerk
Subject
Statistics and analytical issues: SNP and
haplotype analysis
Statistics and analytical issues: SNP and
GWAS data
“Next Gen” HT Sequencing: techniques
and data analysis (1)
“Next Gen” HT Sequencing: techniques
and data analysis (2)
Applications of Next Generation
Sequencing
Attendance fees
The subscription fee of non-commercial participants for the Course is € 350.
Discounts are handled as followed:
 PhD students get a discount of 50% and pay €175.
 Only participants from the postgraduate school MolMed get a discount of
100% and pay €0.
 Other Erasmus MC participants, like Nihes and MGC members and master
students from elsewhere get a discount of 50% and pay €175.
 Master students from elsewhere who pay the fee from their personal
budget get a discount of 75% and pay €87,50.
If these financial requirements pose a problem but you wish to attend the Course, please contact
Frank van Vliet, managing director of the Erasmus Postgraduate School Mol Med, at:
f.vanvliet@erasmusmc.nl.
Invoices
Fees can be paid upon an INVOICE. Shortly after your registration you will receive
the INVOICE per mail. Payment per bank can be done on account: 43.47.01.408 /
Erasmus MC, (IBAN code bank: NL86ANBA0434701408; SWIFT code bank:
ABNANL2A), together with the number on your INVOICE.
Late participants can also pay in cash upon signing in for the Course.
Cancellations
The fees are for all the days of the Course. There is no discount for partaking only
in part of the Course. Our cancellation policy is that cancellation is possible up
to one week before the start of the Course. Later cancellation will not be
accepted, but you are allowed to send a substitute.
Commercial participants & sponsors
Companies are invited to inquire for participation and sponsoring.
3