Post doc position at the Translational Immunotherapy Team of the InstitutCurie, Paris “Human B lymphocytes and cancer: friends or foe or both?” Mentor: Eliane Piaggio, InstitutCurie - Laboratory of Immunology, Paris, France Co-Mentor: Elisabetta Traggiai, NIBR, B cell and Antibody Discovery Lab, Basel, Switzerland Post-doc thematic: Despite B-lymphocytes are a crucial component of the adaptive immune system, little is known about their interaction with cancer cells, their potential antineoplastic functions and/or contribution to tumor progression. However, the immune system is able to generate antibodies to specific cancer antigens and together with recent findings such as the positive prognostic relevance of tumor infiltration by B cells, this is suggestive of a potential anti-tumor function of Blymphocytes. Within the present proposal we will dissect the phenotype and antibody repertoire of human B-lymphocytes in cancer patients, and we will make a special focus on the purinergic signaling in the cross talk between B lymphocytes and cancer cells, opening potential new avenues of immunotherapy intervention. Location: The candidate will be part of the Translational Immunotherapy team of ElianePiaggio, inserted in the Inserm Unit 932 http://u932.curie.frheaded by S. Amigorena. He will also benefit from the high level technological and medicoscientific environment of Institut CurieResearch Center and Hospitalhttp://curie.fr/enlocated in the center of Paris. The 3 years Post-doc position will be available starting from August 2015. Application: Highly motivated and talented Research Fellows with a PhD in Immunology, having a good track record, are welcomed to send their CV, motivation letter and references to: nathalie.amzallag@curie.fr