SDC 1. Neonates with positive blood cultures and/or clinical signs of infection
IAP, interval
BW
GA
from 1st dose
(g)
(wks)
to delivery
Clinical signs of infection¥
Clinical diagnosis
(hours)§
Group 1: Neonates exposed to prolonged rupture of membranes ≥18 hours (PROM)
1
4150
40
12.0
Tachypnea first hour
pneumonia
2
4190
41
13.4
Tachypnea at 12 hours
pneumonia
3
3549
40
3.1
Tachypnea at 33 hours
pneumonia
4
3935
40
5.7
Tachypnea at 26 hours
pneumonia
5
3844
40
1.4
Tachypnea at 38 hours
pneumonia
Group 2: Neonates exposed to chorioamnionitis (CH)
6
4235
39
1.9
Tachypnea at 20 hours
pneumonia
7
3904
41
8.2
Tachypnea at 23 hours
pneumonia
8
3505
9
3164
10
3750
3.5
40
0.2
39
0.7
41
No symptoms; blood culture
grew Enterococcus faecalis
sepsis
Fever (38.5°C); blood culture
grew GBS
sepsis
Cyanotic at 1.5 hours,
required O2 for 9 hours
pneumonia
Transient respiratory
4.1
11
2829
40
symptoms in the DR, resolved
within 4 hours hypoglycemia
pneumonia
Tachypnea at 37 hours;
1.2
12
2805
39
several cyanotic episodes,
temperature instability
pneumonia
Group 3: Neonates exposed to both PROM and chorioamnionitis (PROM + CH)
13
4285
40
4.8
Tachypnea at 16 hours
pneumonia
Temperature instability; blood
culture grew Enterococcus
14
4070
40
3.4
faecalis
sepsis
15
3085
40
1.6
Temperature instability; blood
sepsis
culture grew GBS
Blood culture grew
16
3294
42
3.5
Enterococcus faecalis
sepsis
No symptoms: Blood culture
17
4355
39
4.8
grew GBS
sepsis
18
3635
39
1.2
Tachypnea at 4 hours
pneumonia
19
4414
42
11.3
Tachypnea at 57 hours
pneumonia
39
No IAP
Tachypnea at 10 hours
pneumonia
Group 4: Control
20
3980
BW, birth weight; GA, gestational age; IAP, intrapartum antibiotic prophylaxis; DR, delivery room.
§
Duration of IAP for all patients, median (range) was 3.5 (0.2-13.4) hours. Median (range) for PROM,
CH, PROM+CH groups were 5.7 (1.4-13.4), 1.9 (0.2-8.2), and 3.5 (1.2-11.3) hours, respectively
(p=0.18).
¥
In neonates with tachypnea, the median age at onset (range) was 18 (1-57) hours. Median (range) for
PROM, CH, PROM+CH groups were 26 (1-38), 20 (1-37), and 16 (4-57) hours, respectively (p=0.78).